Stroke:口服抗凝治疗房颤预防中风的地理差异!

2017-07-01 MedSci MedSci原创

口服抗凝药物在预防中风的应用中常常不足;然而,它在地理上是如何变化仍然未知。近期,一项发表在杂志Stroke上的研究旨在评估口服抗凝药物的使用和开始新口服抗凝剂(NOACs)的地理变异。研究者们使用2013年至2014年来自Medicare受益人中5%随机抽样的数据,确定了新诊断患有房颤并开始使用NOAC(n = 8659),华法林(n = 11 771)或未口服抗凝治疗(n = 18 226 )

口服抗凝药物在预防中风的应用中常常不足;然而,它在地理上是如何变化仍然未知。


近期,一项发表在杂志Stroke上的研究旨在评估口服抗凝药物的使用和开始新口服抗凝剂(NOACs)的地理变异。

研究者们使用2013年至2014年来自Medicare受益人中5%随机抽样的数据,确定了新诊断患有房颤并开始使用NOAC(n = 8659),华法林(n = 11 771)或未口服抗凝治疗(n = 18 226 )的患者。根据患者的邮政编码,每位患者被分配到306个Dartmouth医院转介地区中的1个。研究者们构建了逻辑回归,计算了在调整人口、临床和提供者特征和保险类型后,每个医院转诊区域口服抗凝药物的患者开始口服抗凝药物和开始NOAC的平均调整概率。最后,计算了2个概率之间的相关性。

此项研究结果显示:中西部(0.54)和东北(0.54)地区较高,南部地区最低(0.47),开始口服抗凝药物的平均调整概率为0.51,范围为0.32〜0.72。在口服抗凝药物的治疗中,NOAC的平均调整概率为0.42,南部地区最高(0.50),中西部(0.36)和东北(0.39)地区最低。在口服抗凝药物使用率较低的地区,任何口服抗凝药物治疗的患者都更有可能使用NOAC(相关系数-0.16;P = 0.006)。

此项研究结果表明:口服抗凝药物在房颤的治疗中存在较大的地理差异。南方使用口服抗凝药物较低,其卒中率较高。今后,重要的是要分析南方卒中的发病率是否可以部分归因于这一地区口服抗凝药物的不足。

原始出处:
Hernandez I, Saba S, Zhang Y. Geographic Variation in the Use of Oral Anticoagulation Therapy in Stroke Prevention in Atrial Fibrillation. Stroke. 2017 Jun 27. pii: STROKEAHA.117.017683. doi: 10.1161/STROKEAHA.117.017683.

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    2017-07-12 189****7206

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    0

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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Wed Jul 05 00:35:15 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217987, encodeId=ffac21e9875d, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Mon Jul 03 06:54:41 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217730, encodeId=44b321e73043, content=口服抗凝治疗房颤预防中风。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, 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    2017-07-10 184****9840

    学习了谢谢分享

    0

  5. 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    2017-07-08 130****4638

    学习了谢谢分享

    0

  6. 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    2017-07-05 130****4638

    学习了谢谢分享

    0

  7. 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    2017-07-03 184****9840

    学习了谢谢分享

    0

  8. 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    2017-07-02 jyzxjiangqin

    口服抗凝治疗房颤预防中风。

    0

  9. 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    2017-07-02 lou.minghong

    医生的习惯应该是主要因素吧?

    0

  10. 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    2017-07-02 130****4638

    学习了谢谢分享

    0

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2017年6月,发表在《Heart》的一项由美国科学家进行的研究考察了房颤(AF)合并慢性肾病(CKD)患者中,华法林的使用和抗凝控制情况。

房颤消融停用抗凝药导致大脑损伤发生率翻倍

澳大利亚Elisabethinen医院学者在欧洲心律协会2017年会上发布的一项前瞻性研究数据表明,房颤消融前停用抗凝药有可能会导致无症状大脑损伤发生率翻倍,因此研究者建议房颤消融无需停用抗凝药。

JACC:联合抗凝治疗方案不能降低房颤患者心梗发生的风险!

房颤患者的血栓栓塞事件比如中风和心梗的发生风险要更高。尽管对于房颤患者来说,抗凝药物的效果要优于预防卒中的抗血小板药物,但目前用来预防心梗的最佳抗凝方案尚未明确。近日,在国际心血管权威杂志JACC上发表了一篇临床研究,旨在根据抗凝治疗的方案探索了房颤患者首次心梗的发生率,并评估了卒中和出血的风险。

房颤抗凝治疗的3.0时代

上世纪50年代,抗凝治疗迎来了1.0时代。以华法林为代表的维生素K拮抗剂诞世,被广泛用于房颤患者以预防血栓栓塞事件。虽然华法林抗栓效果明确、可靠,但在临床应用中仍面临着治疗窗窄,易受药物、食物影响等诸多问题。人们开始致力于更安全、方便的新型抗凝药物的研发。50年后达比加群等新型口服抗凝药(NOACs)问世,开启了房颤抗凝治疗的2.0时代。随着NOACs临床应用的展开,在诸如急诊手术以及无法控制的出

JACC:孕期不同方案的抗凝治疗对置入有机械性瓣膜的孕母和胎儿的影响不同!

严重的心脏瓣膜疾病可以通过瓣膜置换术治疗恢复正常功能,机械性瓣膜的置入需要接受抗凝治疗。但是孕期的机械性瓣膜的抗凝治疗较特殊,不恰当的治疗可能对孕母和胎儿造成一定的危险。近日,在国际心血管权威杂志JACC上发表了一篇关于孕期机械性瓣膜抗凝治疗对孕妇和胎儿影响的荟萃分析。