Arthritis Rheumatol:伴并发症的类风湿性关节炎疾病活动的不同分级

2017-04-11 MedSci MedSci原创

在伴并发症的RA患者中,通过PtGA衡量的RA疾病活动可能受到个体多种疾病的影响。

近日风湿病权威杂志Arthritis & Rheumatology上发表了一篇文章,旨在量化全球范围内伴并发症RA患者(RA-MM)和单纯RA患者疾病活动(PtGA)评价的差异,并明确导致差异的因素。

研究人员比较了RA-MM患者和单纯RA患者之间的PtGA。对队列进行随访(n = 1,040),RA-MM患者(n = 575)和单纯RA患者的肿胀关节数、触痛关节数、全球评估和疾病持续时间相匹配,分析两组间PtGA(ΔPtGA)的差异。患者特征对匹配队列中ΔPtGA变异的影响表示为半偏R2,并归纳为线性回归模型中总R2的百分比。

结果发现RA-MM患者的PtGA更高(或更差),PtGA升高与更多的并发症相关(P线性趋势<0.01)。在根据疾病活动、年龄和疾病持续时间进行调整后仍有显著差异。将294名RA-MM患者与单纯RA患者进行匹配后,RA-MM患者的平均PtGA的成对比较明显更高(均值±标准差:30.5±24.3),而单纯RA为25.6±22.9,(平均ΔPtGA为4.9±26.7;成对t检验P <0.01 )。影响ΔPtGA的变量为疲劳(18%),疼痛(17%)和改良的健康评估问卷评分(9%)。

在伴并发症的RA患者中,通过PtGA衡量的RA疾病活动可能受到个体多种疾病的影响。与单纯RA患者相比,RA-MM患者PtGA更高(更差)。PtGA的差异主要由疲劳和疼痛的差异来解释。

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    2017-05-25 丁鹏鹏
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    2017-04-13 lmm397
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    2017-04-13 爆笑小医
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