高泌乳素血症是怎么导致的不孕?

2017-03-27 陈倩 生殖医学空间

有时候,有的女性发现自己不怀孕,经过检查才发现原来是得了高泌乳素血症。如何诊治高PRL血症导致的不孕?1.泌乳素在正常非哺乳期水平很低泌乳素是垂体分泌的一种激素,正常情况下在非哺乳期时,泌乳素维持在一个非常低的水平,非哺乳期的女性也不会有泌乳或溢乳的症状。williamhill asia 知道催乳(激)素(prolactin,PRL)其主要功能为促进泌乳。从妊娠7周开始增多,随妊娠进展逐渐增量,妊娠足月分娩前达高峰,约200μ

有时候,有的女性发现自己不怀孕,经过检查才发现原来是得了高泌乳素血症。

如何诊治高PRL血症导致的不孕?

1.泌乳素在正常非哺乳期水平很低

泌乳素是垂体分泌的一种激素,正常情况下在非哺乳期时,泌乳素维持在一个非常低的水平,非哺乳期的女性也不会有泌乳或溢乳的症状。

williamhill asia 知道催乳(激)素(prolactin,PRL)其主要功能为促进泌乳。从妊娠7周开始增多,随妊娠进展逐渐增量,妊娠足月分娩前达高峰,约200μg/L,为非孕女性10μg/L的20倍。

2.高泌乳素血症是在垂体平面发生的问题

大家也许还不太清楚,williamhill asia 女性的月经是受到很多因素影响的,最主要的是下丘脑-垂体-卵巢轴,在任何水平上发生问题,都可以导致闭经或月经不调。高泌乳素血症就是在垂体平面发生了问题。

垂体前叶的各类腺细胞增殖后,都有可能成为各种类型分泌亢进的垂体腺瘤。常见的有催乳细胞增殖分泌过多的泌乳素(PRL),造成闭经-泌乳综合征的垂体泌乳素腺瘤。

3.闭经泌乳可能是高泌乳素血症

如果一位女性,既往月经周期正常,但不明原因出现3个月经周期不来潮,或6个月不来月经,伴有有泌乳或溢乳现象时,就要去妇产科或内分泌科检查,以除外高泌乳素血症了。

一般情况下,医生会仔细询问你的病史(包括月经史、生育史),进行体格检查和妇科检查,抽血查性激素水平和泌乳素水平。

如果发现后者水平升高,还会建议你做头颅影像学检查,帮助诊断是否出现垂体肿瘤。发生垂体肿瘤时,还要请你去眼科做视野的检查呢。

总之,为诊断高泌乳素血症需要很多项目的检查,也只有这样才能更好地决定如何去治疗高泌乳素血症。

4.不孕不育也可能是高泌乳素血症作怪

有时候,有的女性是发现自己不怀孕时,经过检查才发现原来是得了高泌乳素血症。因为当血泌乳素水平升高时,影响卵巢功能,可有闭经、溢乳。所以上面提到的垂体肿瘤、高泌乳素血症是导致女性不孕不育的原因之一。

5.溴隐亭是首选药物

这种疾病并不十分可怕,目前也有很好的治疗方法。包括保守药物治疗和手术治疗等。

大部分患者可应用药物治疗,首选药物为溴隐亭。溴隐亭是多巴胺激动剂,与多巴胺受体结合,可以抑制泌乳素(PRL)的合成和分泌,缩小肿瘤。用法为2.5-5毫克/日。

服用溴隐亭药物的女性要定期测定泌乳素的水平,以观察疗效。准备怀孕时,要咨询内分泌医生是否可以停药。有时在妊娠期间也可能会同时服用溴隐亭,一切都要听从医生的吩咐才是。

垂体大腺瘤症状明显的可能还需手术治疗。

妊娠期间,垂体功能会加强,分泌更活跃,此时,也要注意原有的一些症状是否又重新出现或加重,比如泌乳、头痛、视野改变等,因此还是需要做进一步诊断和治疗的。

6.妊娠后泌乳素也会有一定升高

妊娠后泌乳素会有一定的升高,因为胎盘也可以分泌一定的人胎盘催乳素(HPL),是随着孕周的进展而变化。但当发现泌乳素(PRL)水平异常增高时,还是会对妊娠有一定的影响,除了不容易怀孕以外,还会造成流产等不良结果。

特别提示

值得提醒的是,闭经也有许多其他的原因需要鉴别。乳头溢液时,也需要去乳腺外科检查,以除外是否有乳腺肿瘤的可能。

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    2017-10-20 jktdtl
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likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Tue Mar 28 07:43:43 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183193, encodeId=0bd718319332, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Mar 28 07:41:53 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183143, encodeId=0f2a1831432a, content=看看了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Tue Mar 28 00:34:39 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-04-22 詹鱼

    不错,学习了

    0

  4. 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    2017-03-29 绛珠草小姐

    谢谢分享,学习了。

    0

  5. 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    2017-03-29 ylzr123

    好文,值得点赞,更值得收藏!慢慢领会学习的。

    0

  6. 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likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Tue Mar 28 07:43:43 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183193, encodeId=0bd718319332, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Mar 28 07:41:53 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183143, encodeId=0f2a1831432a, content=看看了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Tue Mar 28 00:34:39 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-03-28 虈亣靌

    学习了谢谢分享

    0

  7. 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createdBy=0bed488, createdName=jktdtl, createdTime=Fri Oct 20 08:45:00 CST 2017, time=2017-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189516, encodeId=662a18951660, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRphX6mAPAojbd1zjUU3jveibex0RDicR9I5rBwIxA8nacoPyETu8PjR9PuosNeBhibYFcHtDF4Tsyd5/0, createdBy=9f9b1671661, createdName=詹鱼, createdTime=Sat Apr 22 00:56:52 CST 2017, time=2017-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183574, encodeId=4d701835e4cb, content=谢谢分享,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Mar 28 21:45:12 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183235, encodeId=29bd1832359a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKfcA3xZnott5TnvcnGrdO58uy0RP4NgPa0Qz8FibHlolypPLEmmcGicSPMJVWQKbRkAY8UVZlFRtGw/132, createdBy=c67f2030047, createdName=喜婷, createdTime=Tue Mar 28 08:45:31 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183197, encodeId=fe4e18319eb6, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Tue Mar 28 07:43:43 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183193, encodeId=0bd718319332, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Mar 28 07:41:53 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183143, encodeId=0f2a1831432a, content=看看了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Tue Mar 28 00:34:39 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-03-28 喜婷

    学习了

    0

  8. 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likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Tue Mar 28 07:43:43 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183193, encodeId=0bd718319332, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Mar 28 07:41:53 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183143, encodeId=0f2a1831432a, content=看看了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Tue Mar 28 00:34:39 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-03-28 医艺依意

    学习了,谢谢

    0

  9. 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likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Tue Mar 28 07:43:43 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183193, encodeId=0bd718319332, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Mar 28 07:41:53 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183143, encodeId=0f2a1831432a, content=看看了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Tue Mar 28 00:34:39 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-03-28 飛歌

    学习了很有用

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=2082974, encodeId=6a4a20829e42b, content=<a href='/topic/show?id=1d5310245258' target=_blank style='color:#2F92EE;'>#高泌乳素血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102452, encryptionId=1d5310245258, topicName=高泌乳素血症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47e62500168, createdName=ms1774076774505970, createdTime=Sat Jul 29 00:45:00 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2037100, encodeId=183c203e10098, content=<a href='/topic/show?id=ba6264e5038' target=_blank style='color:#2F92EE;'>#泌乳素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64750, encryptionId=ba6264e5038, topicName=泌乳素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Fri Oct 20 08:45:00 CST 2017, time=2017-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189516, encodeId=662a18951660, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRphX6mAPAojbd1zjUU3jveibex0RDicR9I5rBwIxA8nacoPyETu8PjR9PuosNeBhibYFcHtDF4Tsyd5/0, createdBy=9f9b1671661, createdName=詹鱼, createdTime=Sat Apr 22 00:56:52 CST 2017, time=2017-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183574, encodeId=4d701835e4cb, content=谢谢分享,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Wed Mar 29 19:31:47 CST 2017, time=2017-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183454, encodeId=bdd718345457, content=好文,值得点赞,更值得收藏!慢慢领会学习的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Mar 29 09:07:09 CST 2017, time=2017-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183332, encodeId=b3e61833329a, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Mar 28 21:45:12 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183235, encodeId=29bd1832359a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKfcA3xZnott5TnvcnGrdO58uy0RP4NgPa0Qz8FibHlolypPLEmmcGicSPMJVWQKbRkAY8UVZlFRtGw/132, createdBy=c67f2030047, createdName=喜婷, createdTime=Tue Mar 28 08:45:31 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183197, encodeId=fe4e18319eb6, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Tue Mar 28 07:43:43 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183193, encodeId=0bd718319332, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Mar 28 07:41:53 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183143, encodeId=0f2a1831432a, content=看看了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Tue Mar 28 00:34:39 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-03-28 xiaotaiyang1

    看看了解一下

    0