Diabetologia:妊娠期糖尿病孕妈妈要小心!

2015-03-23 Mechront 译 MedSci原创

妊娠期间的糖尿病有两种情况,一种为妊娠前已确诊糖尿病,称“糖尿病合并妊娠”;另一种为妊娠前糖代谢正常或有潜在糖耐量减退、妊娠期才出现或确诊的糖尿病,称为“妊娠期糖尿病(GDM)”。妊娠期糖尿病(GDM)孕妇糖代谢多数于产后能恢复正常,但将来患2型糖尿病机会增加。

妊娠期间的糖尿病有两种情况,一种为妊娠前已确诊糖尿病,称“糖尿病合并妊娠”;另一种为妊娠前糖代谢正常或有潜在糖耐量减退、妊娠期才出现或确诊的糖尿病,称为“妊娠期糖尿病(GDM)”。妊娠期糖尿病(GDM)孕妇糖代谢多数于产后能恢复正常,但将来患2型糖尿病机会增加。

Bao W 等人进行了一项前瞻性队列研究,探究妊娠期糖尿病(GDM)患者BMI和体重变化对其以后患2型糖尿病风险的影响。该研究纳入了1991-2001年间共1695名确诊为GDM的孕妇,通过随访、问卷调查,每两年报道一次其BMI、体重和2型糖尿病发生率。

1695名GDM参与者里有259名随访期间诊断为2型糖尿病。在长达18年的随访时间里发现,在基线BMI基础上, BMI增加1 kg/m2, 2型糖尿病风险增加aHR 1.16 (95% CI 1.12, 1.19);最近时间BMI基础上, BMI增加1 kg/m2, 2型糖尿病风险增加aHR 1.16 (95% CI 1.13, 1.20)。GDM孕妇产后体重增加5kg,2型糖尿病风险增加27%(aHR 1.27; 95% CI 1.04, 1.54)。与基线BMI <25.0 kg/m2且诊断体重变化<5 kg人群相比,基线BMI ≥30.0 kg/m2且体重增加≥5 kg其2型糖尿病风险HR of 43.19 (95% CI 13.60, 137.11)。

研究结果表明,诊断为妊娠期糖尿病(GDM)孕妇,其基线BMI、最近时间BMI、以及产后体重增加均与将来患2型糖尿病风险呈正相关。

原始出处:

Bao W1, Yeung E, Tobias DK, Hu FB, Vaag AA, Chavarro JE, Mills JL, Grunnet LG, Bowers K, Ley SH, Kiely M, Olsen SF, Zhang C.Long-term risk of type 2 diabetes mellitus in relation to BMI and weight change among women with a history of gestational diabetes mellitus: a prospective cohort study.Diabetologia. 2015 Mar 22. [Epub ahead of print]

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    2015-10-01 lg.zhao
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    2015-06-11 ljjj1053

    好好学习一下

    0

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    2015-04-11 x35042875

    AKI对心衰临床治疗意义重大,但依然需要研究检验其适用性

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1932333, encodeId=17f81932333dc, content=<a href='/topic/show?id=97cc452e63f' target=_blank style='color:#2F92EE;'>#孕妈妈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45276, encryptionId=97cc452e63f, topicName=孕妈妈)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Thu Oct 01 09:46:00 CST 2015, time=2015-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637058, encodeId=e902163e05845, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Dec 15 18:46:00 CST 2015, time=2015-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759531, encodeId=34db1e59531d9, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Jul 12 09:46:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27112, encodeId=bdc42e1129f, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Thu Jun 11 18:46:00 CST 2015, time=2015-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20336, encodeId=9c612033684, content=AKI对心衰临床治疗意义重大,但依然需要研究检验其适用性, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 22:40:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19215, encodeId=70ac1921583, content=球扩张,在世界许多地方ART仍然无法施行,尤其是在撒哈拉以南非洲地区,在那里IVF诊所仍然没有在大多数国家出现, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Tue Mar 31 23:28:00 CST 2015, time=2015-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250951, encodeId=fc8712509519f, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Wed Mar 25 12:46:00 CST 2015, time=2015-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253575, encodeId=5fdb12535e540, content=<a href='/topic/show?id=9d5d44888a9' target=_blank style='color:#2F92EE;'>#妊娠期糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44888, encryptionId=9d5d44888a9, topicName=妊娠期糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Wed Mar 25 12:46:00 CST 2015, time=2015-03-25, status=1, ipAttribution=)]
    2015-03-31 x35042875

    球扩张,在世界许多地方ART仍然无法施行,尤其是在撒哈拉以南非洲地区,在那里IVF诊所仍然没有在大多数国家出现

    0

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据现今数据表明,约有1-2%的妊娠期妇女感染人类细小病毒B19 (hParvo-B19),其中约有30-50%会通过垂直传播感染胎儿,其后果可造成胎儿贫血、水肿,甚至死亡。目前学术上讨论较多的是胎儿hParvo-B19感染与胎儿贫血,但是对于胎儿血液系统其他方面影响的研究和数据却很少,因此Melamed N等人经行了一项回顾性研究,评估胎儿感染hParvo-B19之后胎儿重度的