惊!长期高脂肪饮食不仅增加你的腰围,还会导致大脑萎缩

2022-08-01 转化医学网 网络

肥胖的人患抑郁症的风险增加了55%,而患糖尿病的风险将增加一倍。

导读:最近,有一个国际研究团队进行了一项实验,确立了高脂肪饮食导致的肥胖和糖尿病与认知能力降低之间的明确联系。这一发现强调了迫切解决全球肥胖流行的重要性。肥胖、年龄和糖尿病的结合是导致认知能力下降、阿尔茨海默病和其他精神健康障碍的重要因素。

新的研究表明,高脂肪食物不仅会使你的腰围增加,还会导致大脑萎缩。

昆明医科大学第二附属医院的熊静和南澳大学(UniSA)神经科学家周新福教授等人领导的一项国际研究已经在高脂肪饮食导致的肥胖和糖尿病与认知能力降低之间确立了明确的联系,认知能力降低包括发展为焦虑、抑郁和恶化的阿尔茨海默病。研究团队在《Metabolic Brain Disease》杂志上发表了他们的研究结果。

https://link.springer.com/article/10.1007/s11011-022-01029-x#citeas

UniSA神经科学家和生物化学家副教授Larisa Bobrovskaya说,这项研究提供了越来越多的证据,表明慢性肥胖和糖尿病与阿尔茨海默病之间存在联系。

阿尔茨海默病(AD)最常见的一种由神经细胞损伤引起的不可逆、退行性脑疾病。它是一种与年龄密切相关的疾病,随着人均寿命的增长,患病人数也在快速增长中。截至目前,全球约有5000万的阿尔茨海默症患者, 而在中国,患病人数超过了1000万。预计到2050年,全球阿尔茨海默病病例将达到1亿例。

阿尔茨海默病的大致病理表现为脑的体积缩小、重量减轻,脑沟加深变宽,脑回萎缩,颞叶特别是海马区萎缩明显,其发病特征是认知功能下降、精神症状和行为障碍、日常生活能力的逐渐下降。大多数患者表现为散发性晚发性,代谢因素在阿尔茨海默病的发生和发展中起重要作用。

Bobrovskaya教授说:“williamhill asia 在对小鼠的研究中证明了:肥胖和糖尿病会损害中枢神经系统,加剧精神疾病和认知能力下降。”

在这项研究中,正常小鼠从八周龄开始,被随机分配成两组。一组按照标准饮食训练,另一组则是高脂肪饮食,实验为期30周。研究人员在不同的时间间隔内监测小鼠的食物摄入量、体重和血糖水平,同时对它们进行葡萄糖和胰岛素耐量测试和认知功能障碍。

与标准饮食的小鼠相比,高脂肪饮食的小鼠体重增加了很多,并产生了胰岛素抵抗,行为开始异常。

而实验的另一端,有一批被喂食高脂肪食物的转基因阿尔茨海默病小鼠也表现出了显著的认知能力退化和大脑病理变化。

Bobrovskaya教授说:“肥胖的人患抑郁症的风险增加了55%,而患糖尿病的风险将增加一倍。williamhill asia 的发现强调了迫切解决全球肥胖流行的重要性。肥胖、年龄和糖尿病的结合是导致认知能力下降、阿尔茨海默病和其他精神健康障碍的重要因素。”

参考资料:

https://medicalxpress.com/news/2022-07-term-high-fat-diet-waistline-brain.html

https://link.springer.com/article/10.1007/s11011-022-01029-x#citeas

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    2022-10-26 chendoc252
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    2022-07-13 naiwu77
  4. [GetPortalCommentsPageByObjectIdResponse(id=1694489, encodeId=2c6b1694489c5, content=<a href='/topic/show?id=e73610261912' target=_blank style='color:#2F92EE;'>#高脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102619, encryptionId=e73610261912, topicName=高脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=831a29654518, createdName=jinweidong, createdTime=Sun Oct 02 17:30:05 CST 2022, time=2022-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696062, encodeId=717116960627f, content=<a href='/topic/show?id=03b98809697' target=_blank style='color:#2F92EE;'>#萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88096, encryptionId=03b98809697, topicName=萎缩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53fc29868494, createdName=chendoc252, createdTime=Wed Oct 26 23:30:05 CST 2022, time=2022-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308155, encodeId=f5d61308155f8, content=<a href='/topic/show?id=8f0085426a7' target=_blank style='color:#2F92EE;'>#腰围#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85426, encryptionId=8f0085426a7, topicName=腰围)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b0e350, createdName=naiwu77, createdTime=Wed Jul 13 11:30:05 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389108, encodeId=5c39138910893, content=<a href='/topic/show?id=d45c10262260' target=_blank style='color:#2F92EE;'>#高脂肪饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102622, encryptionId=d45c10262260, topicName=高脂肪饮食)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed Jul 13 11:30:05 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401240, encodeId=bd08140124069, content=<a href='/topic/show?id=3405850e3f4' target=_blank style='color:#2F92EE;'>#脑萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85073, encryptionId=3405850e3f4, topicName=脑萎缩)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/xdmCjlickSzn2cxg75bTZeYl2VYrTV6hibyMlic5XVFkibQbmFB7tK72afyxE4iclBhv7qd91qSk8Q6yicAcmErXRFxQ/132, createdBy=2c5d2304811, createdName=smartjoy, createdTime=Wed Jul 13 11:30:05 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574694, encodeId=55b415e469486, content=<a href='/topic/show?id=9b56102616bb' target=_blank style='color:#2F92EE;'>#高脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102616, encryptionId=9b56102616bb, topicName=高脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b716021149, createdName=pcw111, createdTime=Wed Jul 13 11:30:05 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625414, encodeId=c0f1162541468, content=<a href='/topic/show?id=dfe143964e4' target=_blank style='color:#2F92EE;'>#大脑萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43964, encryptionId=dfe143964e4, topicName=大脑萎缩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48aa20754836, createdName=gracezdd, createdTime=Wed Jul 13 11:30:05 CST 2022, time=2022-07-13, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1694489, encodeId=2c6b1694489c5, content=<a href='/topic/show?id=e73610261912' target=_blank style='color:#2F92EE;'>#高脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102619, encryptionId=e73610261912, topicName=高脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=831a29654518, createdName=jinweidong, createdTime=Sun Oct 02 17:30:05 CST 2022, time=2022-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696062, encodeId=717116960627f, content=<a href='/topic/show?id=03b98809697' target=_blank style='color:#2F92EE;'>#萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88096, encryptionId=03b98809697, topicName=萎缩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53fc29868494, createdName=chendoc252, createdTime=Wed Oct 26 23:30:05 CST 2022, time=2022-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308155, encodeId=f5d61308155f8, content=<a href='/topic/show?id=8f0085426a7' target=_blank style='color:#2F92EE;'>#腰围#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85426, encryptionId=8f0085426a7, topicName=腰围)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b0e350, createdName=naiwu77, createdTime=Wed Jul 13 11:30:05 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389108, encodeId=5c39138910893, content=<a href='/topic/show?id=d45c10262260' target=_blank style='color:#2F92EE;'>#高脂肪饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102622, encryptionId=d45c10262260, topicName=高脂肪饮食)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed Jul 13 11:30:05 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401240, encodeId=bd08140124069, content=<a href='/topic/show?id=3405850e3f4' target=_blank style='color:#2F92EE;'>#脑萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85073, encryptionId=3405850e3f4, topicName=脑萎缩)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/xdmCjlickSzn2cxg75bTZeYl2VYrTV6hibyMlic5XVFkibQbmFB7tK72afyxE4iclBhv7qd91qSk8Q6yicAcmErXRFxQ/132, createdBy=2c5d2304811, createdName=smartjoy, createdTime=Wed Jul 13 11:30:05 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574694, encodeId=55b415e469486, content=<a href='/topic/show?id=9b56102616bb' target=_blank style='color:#2F92EE;'>#高脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102616, encryptionId=9b56102616bb, topicName=高脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b716021149, createdName=pcw111, createdTime=Wed Jul 13 11:30:05 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625414, encodeId=c0f1162541468, content=<a href='/topic/show?id=dfe143964e4' target=_blank style='color:#2F92EE;'>#大脑萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43964, encryptionId=dfe143964e4, topicName=大脑萎缩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48aa20754836, createdName=gracezdd, createdTime=Wed Jul 13 11:30:05 CST 2022, time=2022-07-13, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1694489, encodeId=2c6b1694489c5, content=<a href='/topic/show?id=e73610261912' target=_blank style='color:#2F92EE;'>#高脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102619, encryptionId=e73610261912, topicName=高脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=831a29654518, createdName=jinweidong, createdTime=Sun Oct 02 17:30:05 CST 2022, time=2022-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696062, encodeId=717116960627f, content=<a href='/topic/show?id=03b98809697' target=_blank style='color:#2F92EE;'>#萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88096, encryptionId=03b98809697, topicName=萎缩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53fc29868494, createdName=chendoc252, createdTime=Wed Oct 26 23:30:05 CST 2022, time=2022-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308155, encodeId=f5d61308155f8, content=<a href='/topic/show?id=8f0085426a7' target=_blank style='color:#2F92EE;'>#腰围#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85426, encryptionId=8f0085426a7, topicName=腰围)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b0e350, createdName=naiwu77, createdTime=Wed Jul 13 11:30:05 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389108, encodeId=5c39138910893, content=<a href='/topic/show?id=d45c10262260' target=_blank style='color:#2F92EE;'>#高脂肪饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102622, encryptionId=d45c10262260, topicName=高脂肪饮食)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed Jul 13 11:30:05 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401240, encodeId=bd08140124069, content=<a href='/topic/show?id=3405850e3f4' target=_blank style='color:#2F92EE;'>#脑萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85073, encryptionId=3405850e3f4, topicName=脑萎缩)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/xdmCjlickSzn2cxg75bTZeYl2VYrTV6hibyMlic5XVFkibQbmFB7tK72afyxE4iclBhv7qd91qSk8Q6yicAcmErXRFxQ/132, createdBy=2c5d2304811, createdName=smartjoy, createdTime=Wed Jul 13 11:30:05 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574694, encodeId=55b415e469486, content=<a href='/topic/show?id=9b56102616bb' target=_blank style='color:#2F92EE;'>#高脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102616, encryptionId=9b56102616bb, topicName=高脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b716021149, createdName=pcw111, createdTime=Wed Jul 13 11:30:05 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625414, encodeId=c0f1162541468, content=<a href='/topic/show?id=dfe143964e4' target=_blank style='color:#2F92EE;'>#大脑萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43964, encryptionId=dfe143964e4, topicName=大脑萎缩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48aa20754836, createdName=gracezdd, createdTime=Wed Jul 13 11:30:05 CST 2022, time=2022-07-13, status=1, ipAttribution=)]
    2022-07-13 pcw111
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Am J Clin Nutr:DHA摄入或对AD高遗传风险者有益

在散发性AD遗传风险增加的中年认知正常个体中,自我报告的膳食DHA被发现与几种有益的脑血管病理或AD相关神经变性相关的脑神经成像表型有关。

Lancet Neurol:氯沙坦尚不能有效改善临床诊断的阿尔茨海默病患者脑萎缩

阿尔茨海默病目前是最昂贵的卫生保健问题之一,中年(50-65岁)的高血压使患痴呆症的风险增加38%。高血压和脑血管功能障碍可导致脑血流量减少、脑血管自动调节功

Hum Brain Mapp:胰岛素抵抗是代谢综合征引起的大脑结构改变的原因

筛查胰岛素抵抗,以及旨在恢复胰岛素敏感性的早期干预,可能对预防与代谢综合征相关的脑萎缩有效。

JNNP:Tau-PET成像预测早期阿尔茨海默病患者认知能力下降和脑萎缩进展

认知神经退行性疾病的体内诊断仍然具有挑战性,依赖于临床、生物学和影像学证据的结合。正电子发射断层扫描(PET)的分子成像能够在体内检测某些蛋白质病变,并提供与脑脊液(CSF)生物标记物类似的病理生理学

JNNP:线性法测量多发性硬化和临床孤立综合征的脑萎缩:一项30年随访研究

多发性硬化症(MS)是一种中枢神经系统的慢性炎症、脱髓鞘和神经退行性疾病。大约85%的MS患者最初患有复发-缓解型(RR)MS,这与炎症性脱髓鞘病变的发生有关,从长期来看,大多数患者会发展为继发性进行

如何鉴别脑萎缩与硬膜下积液?一张表格就掌握!

临床上经常会看到放射科打这样的头颅CT/MRI诊断报告