J Dent Res:牙周损伤的牙槽骨愈合过程中的骨质疏松变化

2019-01-17 lishiting MedSci原创

骨质疏松症会导致骨密度降低以及增加骨折的风险,但是这种疾病如何影响牙槽骨的愈合还未可知。这篇研究的目的是为了评估骨质疏松影响颚骨的程度,并探讨骨质疏松表型影响拔牙后牙槽骨愈合率的可能机制。

骨质疏松症会导致骨密度降低以及增加骨折的风险,但是这种疾病如何影响牙槽骨的愈合还未可知。这篇研究的目的是为了评估骨质疏松影响颚骨的程度,并探讨骨质疏松表型影响拔牙后牙槽骨愈合率的可能机制。

研究利用卵巢切除小鼠模型并进行mciro-CT影像分析、组织学、分子生物学和细胞水平的检测后第一次发现,其四肢以及颚骨均呈现出骨质疏松的表型。随后,研究发现,骨质疏松小鼠的牙周膜(PDL)退缩明显,并且这种退缩还伴随着PDL中骨祖细胞群落的减少。而缺乏PDL来源的骨祖细胞与明显减缓的牙槽窝愈合密切相关。

结论:总的来说,这些分析显示,颚骨对骨质疏松带来的不良反应非常敏感,表现为骨变薄、更多疏松的牙槽骨、PDL变薄和减缓的骨愈合。这些结果对那些接受重建性手术的老年骨质疏松患者具有潜在的临床意义。

原始出处:

Arioka M, Zhang X, et al. Osteoporotic Changes in the Periodontium Impair Alveolar Bone Healing. J Dent Res. 2019 Jan 9:22034518818456. doi: 10.1177/0022034518818456.

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    2019-06-02 mei540
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    2019-06-10 redcrab
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