JCEM:1型糖尿病患者骨矿物质密度

2019-11-03 xing.T MedSci原创

由此可见,在各个年龄段中,T1D女性患者的腰椎BMD与没有糖尿病的年龄和性别相匹配的参与者相似,但绝经后的T1D女性患者腰椎、股骨颈和全髋BMD要低。

1型糖尿病(T1D)患者的骨折风险高于无糖尿病的同伴。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在比较1型糖尿病(T1D)患者以及年龄和性别相匹配的健康对照者的整个生命周期内骨矿物质密度(BMD)

研究人员进行了一项横断面研究,T1D受试者(5至71岁)以及匹配对照患者来自Barbara Davis糖尿病研究中心正在进行的研究。参与者接受双X线吸收法(DXA)的腰椎BMD检查,且分为两组:≤20岁的儿童和>20岁的成人。该研究的主要结局指标使用针对年龄和体重指数(成人BMI;儿童的BMI的z评分)进行调整的线性最小二乘模型比较各年龄段和性别的糖尿病患者的BMD。

研究人员对194 名T1D的患者和156名对照者的腰椎BMD进行了分析。T1D患者与对照者之间经年龄和BMI调整的腰椎BMD没有差异:在男孩中(最小二乘均数[LSM±SEM]; 0.80±0.01 vs. 0.80±0.02 gm/cm2,p=0.98)或成人(1.01±0.03 vs. 1.01±0.03 gm/cm2,p=0.95)和女童(0.78±0.02 vs. 0.81±0.02 gm/cm2,p=0.23)或成人(0.98±0.02 vs. 1.01±0.02 gm/cm2, p=0.19)。患有T1D的绝经后妇女腰椎(0.98±0.02 vs. 1.04±0.02 gm/cm2,p=0.05)、股骨颈(0.71±0.02 vs. 0.79±0.02 gm/cm2,p=0.003)和全髋(0.84±0.02 vs. 0.91±0.02, p=0.005)的BMD与没有糖尿病的绝经后妇女相比要低。

由此可见,在各个年龄段中,T1D女性患者的腰椎BMD与没有糖尿病的年龄和性别相匹配的参与者相似,但绝经后的T1D女性患者腰椎、股骨颈和全髋BMD要低。 

原始出处:

Eitan Halper-Stromberg,et al.Bone Mineral Density across the Life-Span in Patients with Type 1 Diabetes.J Clin Endocrinol Metab.2019.https://doi.org/10.1210/clinem/dgz153

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    2019-12-10 achengzhao
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    2020-10-12 smallant2015
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    2019-11-03 misszhang

    谢谢MedSci提供最新的威廉亚洲官网

    0

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