患者-呼吸机不同步对COPD患者机械通气撤机失败的预测作用

2021-07-27 MedSci原创 MedSci原创

患者-呼吸机不同步即患者自主呼吸和呼吸机辅助通气在吸气、呼气时相上不同步,在机械通气的COPD患者中,患者-呼吸机不同步是一个常见的问题。高异步性指数和高无效触发指数可能是这些患者脱机失败的早期预测因

机械通气对呼吸衰竭有良好的治疗作用,对合并呼吸衰竭的慢性阻塞性肺疾病(COPD)患者可显著改善呼吸困难症状。患者-呼吸机不同步是机械通气患者的常见问题,有研究表明80%的COPD患者机械通气时发生过患者-呼吸机不同步现象。患者-呼吸机不同步会导致呼吸功增加、患者不适、需要镇静增加、机械通气延长、脱机困难和脱机失败等。患者-呼吸机不同步及其对COPD患者机械通气脱机结局的影响有待研究。研究者纳入2018年2月至2019年8月在AsSuit大学附属医院呼吸重症监护病房的100名机械通气的COPD患者进行前瞻性研究。对纳入者分别在插管前、插管后24小时、自主呼吸试验(SBT)期间、脱机后2小时、脱机后24小时以及有临床需求时采集动脉血气,记录临床和呼吸机数据,测定镇静时间和纳入研究前的机械通气时间。研究基线特征包括年龄、性别、吸烟史、当前病史和疾病严重程度由急性生理学和慢性健康评估II(APACHE II)评估。

此次研究纳入的100例COPD患者中,脱机失败(需要NIV或48h内重新插管)(27%)27例,脱机成功73例(73%)。脱机失败组的异步指数(A.I)和无效触发指数(ITI)明显高于脱机成功组(分别为7.69±3.71、3.46±2.59和6.27±3.14、2.47±2.08,P<0.04)。

脱机失败的COPD患者的吸烟指数、APACHE II评分、机械通气时间、呼吸频率、峰压、浅快呼吸指数、PEEP水平、镇静时间显著高于脱机成功组。

在>25时,无效触发事件预测脱机失败的敏感度和特异度分别为56%和85%,曲线下面积为0.66。总异步性预测脱机失败的敏感度为77%,特异度为73%,曲线下面积为0.52。

结论:高异步性指数和高无效触发指数可能是机械通气COPD患者脱机失败的早期预测指标。

 

出处:Patient ventilator asynchrony as a predictor of weaning failure in mechanically ventilated COPD patients

Maha Elkholy, Samiaa Sadek, Reham Elmorshedy, marwa abdulmoez

European Respiratory Journal Sep 2020, 56 (suppl 64) 3726; DOI: 10.1183/13993003.congress-2020.3726

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    2021-07-27 williamhill asia 小助手M

    学习了

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    2021-07-25 Boyinsh
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    2021-07-25 gous