JACC:不同抗凝药物对房颤患者骨折风险的影响

2019-10-27 不详 MedSci原创

长期服用维生素k拮抗剂(VKAs)的老年人更容易患骨质疏松,本研究的目的旨在比较和评估接受VKA治疗和直接口服抗凝剂(DOACs)房颤患者的骨质疏松风险。本研究纳入分析了37350名房颤患者,主要终点事件是髋部骨折、要骨质疏松性骨折、任何骨折、开始骨质疏松药物治疗和一个联合终点。相比于接受VKA治疗的患者,接受DOACs治疗患者的2年骨折风险要更低(3.1%vs3.8%),DOAC与更低的骨折([

长期服用维生素k拮抗剂(VKAs)的老年人更容易患骨质疏松,本研究的目的旨在比较和评估接受VKA治疗和直接口服抗凝剂(DOACs)房颤患者的骨质疏松风险。

本研究纳入分析了37350名房颤患者,主要终点事件是髋部骨折、要骨质疏松性骨折、任何骨折、开始骨质疏松药物治疗和一个联合终点。相比于接受VKA治疗的患者,接受DOACs治疗患者的2年骨折风险要更低(3.1%vs3.8%),DOAC与更低的骨折([HR]: 0.85; 95% CI: 0.74-0.97)、要骨质疏松性骨折(HR: 0.85; 95% CI: 0.72-0.99)和开始骨质疏松药物治疗(HR: 0.82; 95% CI: 0.71-0.95)风险呈明显相关。

研究结果显示,在接受口服抗凝治疗的房颤患者中,骨质疏松性骨折的发生率较低,但是与VKA相比,DOAC的骨折发生风险更低。

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    2020-08-27 hbwxf
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