Am J Cardiol:饮酒不会增加老年高血压患者患心衰的风险

2018-11-18 佚名 嘉音

在线发表于《The American Journal of Cardiology》杂志上的一项研究表明,饮酒与老年高血压患者患心衰的风险无关。

在线发表于《The American Journal of Cardiology》杂志上的一项研究表明,饮酒与老年高血压患者患心衰的风险无关。

尽管大量酒精摄入与心肌病的发生相关,但是适量的酒精摄入对心衰风险的影响仍不清楚。因此澳大利亚彭里斯西悉尼大学的Berhe Sahle博士和同事分析了来自澳大利亚彭里斯西部大学的6083例澳大利亚国家高血压研究受试者的数据。高血压患者的年龄为65~84岁。排除了研究前6个月内患有卒中心肌梗死、心衰、急进性或恶性高血压和痴呆病史的患者。在基线测量了受试者的血压,并从医疗记录中获得实验室生化指标等测量值。

采用调查问卷收集了生活方式以及饮酒频率和数量等信息。患者需报告他们的饮酒状态:从未饮酒(n=1289;平均年龄73岁;32%女性),已经戒酒(n=394;平均年龄72岁;女性5%),一周饮酒1~7次(n=2409;平均年龄72岁;43%女性),每周饮用8~14杯饮料(n=1217;平均年龄72岁;17%女性)或每周饮用超过14杯饮料(n=774;平均年龄73岁;4%女性)。随访直至2011年9月16日,并统计了心衰事件的发生。

研究结果发现在10.8年的中位随访期间,319例患者(57%的男性)发生了心衰事件,发病率为5.4例/1000人年(95% CI,4.8~6)。在调整多种混杂因素后,心衰的风险与男性或女性的饮酒量没有显著关联。相比于从未饮酒的患者,每周饮酒一至七次的女性的危险比为0.87(95% CI,0.59~1.3),而饮酒频率为每周8~14次的女性为0.96(95% CI,0.57~1.6),每周饮酒超过14杯的女性的心衰危险比为0.71(95% CI,0.25~2.02)。男性中非饮酒者的心衰危险比在每周饮用一至七杯饮料的人中为0.81(95% CI,0.47~1.38),对于那些饮用8~14杯饮料的人为0.77(95% CI,0.43~1.38),每周饮酒量超过14杯的为1.04(95% CI,0.59~1.84)。在整个试验期间将酒精摄入量的四分位数与从未饮酒的患者进行比较时,这些结果没有改变。

研究作者Sahle及其同事写道:“与中度饮酒相关的心衰风险或益处的不一致可能部分是由于研究人群年龄的变化,以及不同临床工作中对定义的不同和/或其他合并症的存在。” “由于年龄相关的身体成分变化,老年人更容易受到酒精的不良影响。因此,相同数量的酒精在老年人中产生的血液酒精浓度高于中年人,这可能会削弱在中年人群中观察到的适度饮酒的益处。”

原始出处:
Sahle BW, et al. Alcohol consumption not linked to HF risk in older adults with hypertension. The American Journal of Cardiology. Jul 2018.

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    2018-11-20 txqjm

    谢谢了,学习

    0

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    2018-11-19 深海的鱼

    学习学习学习

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    2018-11-19 smartxiuxiu

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