Nature Metabolism:铁证如山!多所英美**学府研究证实饥饿感由血糖引起

2021-04-13 Oranhgy MedSci原创

在进食后几个小时,血糖水平出现大跌的人,最终会比其他人饥饿感更强。

近期,伦敦国王学院和健康科学公司ZOE的研究团队(包括来自哈佛医学院、哈佛T.H。陈公共卫生学院、麻省总医院、诺丁汉大学、利兹大学和瑞典隆德大学的科学家)联合发表在《自然代谢》上的一项研究表明,在进食后几个小时,血糖水平出现大跌的人,最终会比其他人饥饿感更强。

该研究结果来自世界上最大的正在进行的营养研究计划PREDICT,该计划关注真实生活环境中对食物的反应,寻找即使在控制卡路里的饮食中也难以减肥的原因,以及在饮食和健康方面了解个人新陈代谢的重要性。

研究团队收集了1070人在两周内吃完标准化早餐和自由选择的餐食后的血糖反应和其他健康标志物的详细数据,共有8000多份早餐和7万多份餐食。标准早餐均以松饼为主,在控制相同的热量前提下,在碳水化合物、蛋白质、脂肪和纤维等方面的成分有所不同。

参与者佩戴贴式连续血糖监测仪(CGM)来测量他们在整个研究期间的血糖水平,以及一个可穿戴设备来监测活动和睡眠。通过收集应用程序记录饥饿感确切的时间。此外,参与者还进行了空腹血糖反应测试(口服葡萄糖耐量试验),以测量他们的身体对糖的处理情况。

在比较参与者吃同样的测试餐时的情况后,研究人员发现参与者之间的血糖反应有很大差异。以往研究进食后的血糖,都集中在餐后头两个小时内水平的升降方式,即所谓的血糖峰值。然而,在分析数据后,PREDICT团队注意到,一些人在这个初始峰值后的2-4小时内经历了显著的 "糖分骤降",他们的血糖水平在回升之前迅速降至基线以下。

参与者血糖情况

进食后血糖大幅下降的人比其他人饥饿感增加了9%。在早餐后的3-4小时内,这些进食后会出现血糖水平大幅下降的人会多摄入75卡路里的热量,而全天范围内,他们更是多摄入了约312卡路里的热量。这种行为模式可能会导致一年中体重增加20磅(约等于9公斤)。

clevelandclinic

事实上,此前人们一直怀疑血糖水平在控制饥饿方面发挥着重要作用,但之前的各种研究结果并不确定。而如今该研究结果很明显地表明,与进食后的初始血糖峰值反应相比,糖分的下降更能预测饥饿感和随后的卡路里摄入量,这也改变了williamhill asia 对血糖水平和所吃食物之间关系的思考。

参考文献:

Wyatt, P., Berry, S.E., Finlayson, G. et al. Postprandial glycaemic dips predict appetite and energy intake in healthy individuals. Nat Metab (2021).  doi.org/10.1038/s42255-021-00383-x

 

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    2021-11-04 guojianrong
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GetPortalCommentsPageByObjectIdResponse(id=1896831, encodeId=4f5618968319e, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Apr 28 20:52:12 CST 2021, time=2021-04-28, status=1, ipAttribution=)]
    2021-04-15 xlysu
  5. 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GetPortalCommentsPageByObjectIdResponse(id=1896831, encodeId=4f5618968319e, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Apr 28 20:52:12 CST 2021, time=2021-04-28, status=1, ipAttribution=)]
    2021-04-15 xlysu
  6. 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  7. 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    2021-04-15 闆锋旦
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    2021-04-14 GY058774

    有意义

    0

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    2021-04-13 我要当大牛

    一个疑问🤔️糖尿病人血糖那么高,他们为什么还多饮多食?

    1

    展开1条回复
  10. 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    2021-04-28 一闲

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Am J Clin Nutr :高脂牛奶大胆喝,乳制品(≥3份/天)对糖尿病患者的血糖、体重无影响

糖尿病,部分是由于饮食习惯不健康导致的。例如,暴饮暴食、大鱼大肉以及偏少的五谷杂粮等等。如果按照这种理论,那么有人会反问:乳制品属于营养品,而且还是高脂的乳制品,真的可以随便喝吗?

AJCN:乳制品对调节血糖无益处

既往研究显示,较高浓度的脂肪酸生物标记物(乳制品脂肪摄入量)与较低的2型糖尿病发病率有关。然而,很少有试验评估乳制品对血糖稳态的影响,包括发酵或全脂乳制品。

Diabetes:血糖、认知功能、大脑结构与痴呆之间的关系

很少证据表明T2D或外周血糖的遗传工具与中年认知和大脑结构的指标之间存在因果关系。

JAHA:术前血糖和糖化血红蛋白水平与非心脏手术后心肌损伤之间的关系

术前高血糖与MINS和30天死亡率相关,而HbA1c与此无关。在非心脏手术患者中,短期内控制血糖可能比长期控制血糖更重要。

拓展阅读

JAHA:糖尿病和血糖对机械循环支持后心脏改善和不良事件的影响

T2D和LVAD植入前血糖改变了LVAD的心脏功能改善潜力和不良事件的风险。LVAD植入前血糖控制优化对这些结局的有利影响程度和持续时间值得进一步研究。

JDB杂志期刊精要 | 丹麦全国研究:GLP-1RA和DPP-4i的血糖控制水平与心血管结局比较

该研究强调了血糖控制在影响糖尿病治疗的心血管结局中的重要性,GLP-1RA疗法在达到较低HbA1c水平时可能带来心血管获益。

降体脂不掉肌肉,还能降血糖!换种饮食方式或有新惊喜 | ADA 2024速递

2024年ADA公布了的一项亚组分析研究或许可解答上述问题,该研究结果表明,相比于个体化饮食策略,结构化医学营养疗法能够在维持去脂体重的同时,改善血糖并降低体脂率。

糖化血红蛋白评估血糖靠谱吗?

本文介绍了糖化血红蛋白与血糖检测的不同点,以及糖化血红蛋白与平均血糖、即时血糖的关系,分析了影响糖化血红蛋白检测的因素,最后得出糖化血红蛋白不能代替血糖监测的结论。

Cardiovasc Diabetol:血糖水平与无症状心肌梗死的关系

随着时间的推移,较高的纵向FG和更大的FG变异性以剂量-反应方式与更高的SMI风险相关。这些发现支持常规心脏筛查对血糖升高受试者的重要性,无论是否患有糖尿病。

超50%人正在步入糖尿病!2大策略可降糖减重,糖耐1小时血糖更早发现患者

糖尿病前期患者非常普遍。早期发现糖尿病前期人群,采取适合的方式进行干预,是预防和控制糖尿病前期进展为糖尿病的主要手段。