Diabetes Care:急性心肌梗塞急慢性血糖升高的预后价值!

2018-02-01 xing.T MedSci原创

在AMI糖尿病患者中,A/C血糖比率比入院时血糖能更好地预测发病率和死亡率。

急性高血糖是急性心肌梗死(AMI)预后不良的有力预测指标,特别是无糖尿病的患者。这强调了入院时单纯的急性血糖升高而非血糖水平的重要性。近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员调查了AMI患者联合评价急性和慢性血糖水平,与入院单纯的血糖相比,可能有更好的预后价值。

研究人员通过以下公式估计入院时血糖浓度和估计的平均慢性葡萄糖水平(mg/dL):[(28.7×糖化血红蛋白%)-46.7],并1553例连续就诊的AMI患者(平均年龄为67±13岁)计算急性-慢性(A/C) 比值。该研究的主要终点是院内死亡、急性肺水肿和心源性休克的组合事件。

主要终点事件发生率与A/C血糖比值三分位数同步增加(分别为5%、8%和20%; P<0.0001)。在肌钙蛋白I峰值也可以观察到同步增加(15±34ng/mL、34±66ng/mL和68±131ng/mL; P<0.0001)。在多变量分析中,即使在调整了主要混杂因素之后,A/C血糖比和肌钙蛋白I峰值仍然是主要终点的独立预测因子。在重新分类分析中,A/C血糖比值在预测主要终点方面显示出最好的预测能力,与整个人群入院时的血糖相比(净重分类改善12%[95%CI为4-20%]; P=0.003),尤其是在糖尿病患者中(27%[95%CI为14-40%]; P<0.0001)。

在AMI糖尿病患者中,A/C血糖比率比入院时血糖能更好地预测发病率和死亡率。

原始出处:


Giancarlo Marenzi,et al. Prognostic Value of the Acute-to-Chronic Glycemic Ratio at Admission in Acute Myocardial Infarction: A Prospective Study.Diabetes Care 2018.https://doi.org/10.2337/dc17-1732

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    2018-12-31 仁医06
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    2018-02-01 戒馋,懒,贪

    谢谢分享学习了

    0

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