Gastroenterology: 有锯齿状息肉病史的人大肠癌的风险明显增加

2020-04-11 MedSci原创 MedSci原创

锯齿状息肉(SPs)是20%–30%的大肠肿瘤病例的癌前病变事件,但目前williamhill asia 对SP切除后的长期风险了解甚少。因此,本项研究探究了有SP病史的个体患结直肠癌(CRC)的风险。

背景及目的: 锯齿状息肉(SPs)是20%–30%的大肠肿瘤病例的癌前病变事件,但目前williamhill asia 对SP切除后的长期风险了解甚少。因此,本项研究探究了有SP病史的个体患结直肠癌(CRC)的风险。

方法:研究人员对2006年至2016年接受结肠镜检查的患者进行了一项回顾性队列研究。研究对象根据SP的大小和位置进行分类。使用Cox比例风险模型估算了结肠镜检查后1年以上被诊断为CRC的关联的风险。

结果:该研究包括233393个人,其中445人发生了CRC事件。在随访第10年时,无息肉,近端小SP,近端大SP和远端SP的CRC的累积发生率分别为4.7(95%CI,4.0-5.6),14.8(95%CI,9.0-24.3),30.2(95%CI,13.2-68.4)和5.9(95%CI,3.6-9.5)。在患有SP的患者中,直到第一次结肠镜检查后3年,CRC的风险才增加(小型近端SP的HR为2.6; 95%CI为1.7-3.9;大型近端SP的HR为8.0、95%CI为3.6–16.1)。腺瘤的存在也增加了CRC的风险(腺瘤的近端SP的HR为4.0、95%CI,3.0-5.5,腺瘤的HR远端SP为2.4、95%CI为1.7-3.4)。

结论:在这项回顾性分析中,研究人员发现在结肠镜检查后3年或更长时间,近端SP(尤其是大SP)患者的发生CRC的风险增加。

原始出处:

Dan Li. Et al. Increased Risk of Colorectal Cancer in Individuals With a History of Serrated Polyps. Gastroenterology.2020.

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