Gastroenterology:论肠道内镜医师业务能力与患者肠癌发病率和死亡风险

2017-04-29 zhangfan MedSci原创

增加结肠镜检查腺瘤检出率可有效降低患者的结肠癌以及死亡风险

结肠镜检查是检测肠道腺瘤的有效方法,腺瘤检出率(ADR)是评价内镜医师能力的主要指标,普遍认为腺瘤检出率与结直肠癌死亡呈负相关。近日研究人员开展一项研究旨在验证提高腺瘤检出率是否有助于减少大肠癌发病率和死亡风险。

研究人员获取了2004年至2008年波兰国家大肠癌筛查项目中294名内镜医师的146860结肠镜检查结果资料,采用多元模型评估提高ADR对大肠癌和死亡风险的影响。

统计表明在研究期间,共219医生(74.5%)提高了其年度ADR,在随后的895916患者年中,共发生168例大肠癌和44例癌症死亡。提高ADR与结肠癌发生的调整后风险比为0.63 (95% CI, 0.45-0.88; P=0.006),与结肠癌死亡的调整后风险比为0.50 (95% CI, 0.27-0.95; P=0.035)。相比于未提高ADR的医生,达到或维持高检出率(高于24.56%)可以降低结肠癌发生调整后风险比0.27 (95% CI, 0.12-0.63; P=0.003,降低结肠癌死亡调整后风险比为0.18。

研究表明,增加结肠镜检查腺瘤检出率可有效降低患者的结肠癌以及死亡风险。

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createdTime=Sun Apr 30 23:34:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071749, encodeId=e2b420e174981, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Aug 25 05:34:00 CST 2017, time=2017-08-25, status=1, ipAttribution=)]
  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat May 06 10:00:14 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255629, encodeId=8796125562917, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Apr 30 23:34:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1261912, 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  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat May 06 10:00:14 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255629, encodeId=8796125562917, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Apr 30 23:34:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1261912, encodeId=da7f126191214, content=<a href='/topic/show?id=0ceb30545e0' target=_blank style='color:#2F92EE;'>#内镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30545, encryptionId=0ceb30545e0, topicName=内镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun Apr 30 23:34:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504276, encodeId=0c2215042e6b9, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Sun Apr 30 23:34:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071749, encodeId=e2b420e174981, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Aug 25 05:34:00 CST 2017, time=2017-08-25, status=1, ipAttribution=)]
    2017-05-06 1e10c84am36(暂无匿称)

    文章不错,值得拜读

    0

  7. 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createdTime=Sun Apr 30 23:34:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071749, encodeId=e2b420e174981, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Aug 25 05:34:00 CST 2017, time=2017-08-25, status=1, ipAttribution=)]
  8. 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encodeId=da7f126191214, content=<a href='/topic/show?id=0ceb30545e0' target=_blank style='color:#2F92EE;'>#内镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30545, encryptionId=0ceb30545e0, topicName=内镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun Apr 30 23:34:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504276, encodeId=0c2215042e6b9, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Sun Apr 30 23:34:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071749, encodeId=e2b420e174981, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Aug 25 05:34:00 CST 2017, time=2017-08-25, status=1, ipAttribution=)]
    2017-04-30 docwu2019
  9. 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  10. 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    2017-08-25 许安

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阻断PD-1免疫检查点信号通路可以改善肿瘤患者临床结局。有研究证据表明阿司匹林不仅能延长结直肠癌患者生存期,还能激活T细胞介导的抗肿瘤免疫,通过抑制前列腺素E2产生与免疫治疗协同发挥作用。

JAMA:FIT阳性后多久应该进行结肠镜检查?

粪便免疫化学检测(FIT)阳性结果预示着患结肠直肠癌风险的升高,在得到FIT阳性检测结果后是否应进行结肠镜检查?

SCI REP:高表达MMP16与结直肠癌侵袭性行为及不良预后有关

基质金属蛋白酶(MMPs)参与许多生理及病理过程,如伤口愈合、组织修复及重塑等。MMPs在肿瘤细胞增殖迁移中也起到了重要作用。近期有证据表明基质金属蛋白酶16(MMP16)与几种肿瘤的进展有关。但是MMP16在结直肠癌中的研究尚缺乏

Lancet:仅一次软式乙状结肠镜检查竟有如此“奇效”

英国软式乙状结肠镜筛查试验(UK Flexible Sigmoidoscopy Screening Trial,UKFSST)考察一次软式乙状结肠镜筛查的效果大小和持续时间,针对55岁~64岁患者的结直肠癌发病率和死亡率。2017年4月,本试验发表在《Lancet》上,考察了仅一次软式乙状结肠镜17年随访后的长期效果。

JCO:围手术期肝动脉灌注泵化疗可以改善结直肠癌肝转移灶切除后患者生存情况

结直肠癌是美国发病第三的肿瘤,许多患者会出现肝转移。合并肝转移的患者10年总生存率仅为20%。结直肠癌肝转移灶切除后,许多患者会出现复发,其中一半的患者肝脏为唯一的复发部位。因此发明了通过肝动脉的局部化疗方式。