Eur Heart J:收缩压与痴呆的关系!

2018-06-16 xing.T MedSci原创

由此可见,50岁时收缩压超过130mmHg,低于传统的高血压定义超过140mmHg,与患痴呆的风险增加有关;在这些人中,这种过度的风险与CVD无关。

近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员旨在明确50岁、60岁和70岁时的舒张压和收缩压(SBP)与痴呆发生率之间的关系,以及在随访期间发生的心血管疾病(CVD)是否介导了这种联系。

研究人员分别于1985、1991、1997和2003年测量了Whitehall II队列研究中8639名(32.5%女性)受试者的收缩压和舒张压。痴呆的发生率(n痴呆/n总=385/8639)是通过随访受试者的电子健康记录至2017年来确定的。

通过使用连续血压测量的三次样条曲线表明在50岁时SBP超过130mmHg,而不是在60岁或70岁,与增加的痴呆风险相关,对社会经济因素、健康行为和随时间变化的慢性疾病调整后的Cox回归分析予以了证实(风险比(HR)为1.38;95%可信区间(95%CI)为1.11-1.70)。舒张压与痴呆无关。年龄在45岁至61岁之间的高血压患者(SBP超过130mmHg)与无高血压或高血压时间较短的患者相比,痴呆的风险增加(HR为1.29,95%CI为1-1.66)。在多状态模型中,50岁时SBP超过130mmHg与随访期间无心血管疾病患者更高的痴呆风险相关(HR为1.47,95%CI为1.15-1.87)。

由此可见,50岁时收缩压超过130mmHg,低于传统的高血压定义超过140mmHg,与患痴呆的风险增加有关;在这些人中,这种过度的风险与CVD无关。

原始出处:


Jessica G Abell,et al. Association between systolic blood pressure and dementia in the Whitehall II cohort study: role of age, duration, and threshold used to define hypertension. Eur Heart J.2018. https://doi.org/10.1093/eurheartj/ehy288

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    2018-06-17 zhaojie88
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createdTime=Sat Jun 16 22:41:57 CST 2018, time=2018-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324656, encodeId=9166324656dd, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sat Jun 16 13:27:11 CST 2018, time=2018-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324641, encodeId=689d324641cd, content=期待更多研究成果.对临床很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Jun 16 11:37:29 CST 2018, time=2018-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324626, encodeId=f8333246263d, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Jun 16 10:51:53 CST 2018, time=2018-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324620, encodeId=f37c324620d6, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Jun 16 09:16:38 CST 2018, time=2018-06-16, status=1, ipAttribution=)]
    2018-06-16 120fafe0m52暂无昵称

    学习了

    0

  5. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Jun 16 09:16:38 CST 2018, time=2018-06-16, status=1, ipAttribution=)]
    2018-06-16 易水河

    学习学习

    0

  6. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Jun 16 09:16:38 CST 2018, time=2018-06-16, status=1, ipAttribution=)]
    2018-06-16 医者仁心5538

    期待更多研究成果.对临床很有帮助.

    0

  7. 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    2018-06-16 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

  8. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Jun 16 09:16:38 CST 2018, time=2018-06-16, status=1, ipAttribution=)]
    2018-06-16 神功盖世

    0

  9. 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    2018-06-16 龙胆草

    学习谢谢分享

    0

  10. 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    2018-06-16 flysky120

    学习一下知识血压的知识

    0

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