Annals of Neurology: 新冠重症患者中神经元损伤常见且明显

2021-01-24 Freeman MedSci原创

新冠重症患者中神经元损伤常见且明显

据报道,新型患者中高达36%会出现神经系统症状。动物模型和人类解剖研究表明,其他冠状病毒(特别是严重急性呼吸综合征冠状病毒[SARS-CoV])对神经系统有影响。因此,需要对SARS-CoV2(即新冠病毒)损害外周和中枢神经系统(CNS)的可能性进行调查,以区分导致的的神经症状是结构性损伤相关的,还是可逆性神经功能障碍,这种区分是预后长期后遗症的关键。

神经丝轻链(NfL)代表了神经元细胞骨架的主要成分,并在轴突生长、稳定性和细胞内运输中发挥作用;血清NfL(sNfL)是一种特异性反映神经轴突损伤的血型标志物,在包括中枢神经系统急性(缺血性中风、缺氧缺血性脑病)和慢性(多发性硬化和脑小血管病)疾病的研究中显示。

瑞士巴塞尔大学的Raoul Sutter等人,在以下患者中测量了sNfL浓度: 29名重症COVID-19患者,10名重症但非COVID-19患者,以及259名健康对照。在调整神经系统合并症和年龄后,和其他对照组和重症和非COVID-19相比,他们发现了SNfL在患有COVID-19的患者体内浓度较高。较高的sNfL水平与不利的短期临床结果(比如肾功能不足,多器官衰竭)息息有关,这表明在危重的新冠患者中神经损伤是常见的,而且是比较明显的。

原文出处:
Sutter, R., Hert, L., De Marchis, G. M., Twerenbold, R., Kappos, L., Naegelin, Y., ... & Kuhle, J. (2020). Serum neurofilament light chain levels in the intensive care unit: comparison between severely ill patients with and without COVID‐19. _Annals of neurology_.

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    2021-01-24 公卫新人

    新冠肺炎,疫情何时才能消失

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