Gastroenterology:结肠镜过程中辅助麻醉增加吸入性肺炎风险

2018-01-16 zhangfan MedSci原创

研究发现,结肠镜过程中辅助麻醉会导致患者吸入性肺炎风险增加,但不会增加肠穿孔或脾损伤风险。内窥镜医生应该警告病人,尤其是呼吸困难患者,要注意风险防控

结肠镜检查过程中异丙酚联合辅助麻醉(AA)可实现深度镇静,但并发症风险也同时提高。近日研究人员考察了结肠镜AA过程中并发症发生率,特别是肠穿孔,吸入性肺炎以及脾损伤。

在这项使用管理数据库的人口的队列研究中,研究人员考察了加拿大安大略省2005-12年门诊结肠镜成年患者资料。研究的主要终点为肠穿孔,次要终点包括脾损伤与吸入性肺炎。采用配对倾向评分法,考察AA结肠镜与无AA结肠镜检查患者终点发生率,在广义估计方程的基础上,采用逻辑回归模型,探讨了AA与主要终点结果之间的关系。

总计3059045名结肠镜患者参与研究,其中862817人接受AA。倾向匹配后,793073名AA患者以及793073名非AA患者参与研究,其中女性占51%,78%的患者50岁以上。研究发现,AA不会导致肠穿孔 (OR, 0.99; 95% CI, 0.84-1.16) 或脾损伤(OR, 1.09; 95% CI, 0.62-1.90)风险增加,但AA导致吸入性肺炎风险增加(OR, 1.63; 95% CI, 1.11-2.37)。

研究发现,结肠镜过程中辅助麻醉会导致患者吸入性肺炎风险增加,但不会增加肠穿孔或脾损伤风险。内窥镜医生应该警告病人,尤其是呼吸困难患者,要注意风险防控。

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createdName=chaojitidian, createdTime=Thu Jan 18 04:17:00 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279197, encodeId=b91d2e91971c, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Jan 16 21:04:14 CST 2018, time=2018-01-16, status=1, ipAttribution=)]
    2018-07-23 heli0118
  5. 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createdName=chaojitidian, createdTime=Thu Jan 18 04:17:00 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279197, encodeId=b91d2e91971c, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Jan 16 21:04:14 CST 2018, time=2018-01-16, status=1, ipAttribution=)]
    2018-01-26 大爰

    学习了谢谢分享!!

    0

  7. 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    2018-01-18 jyzxjiangqin

    结肠镜的应用.

    0

  8. 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createdName=chaojitidian, createdTime=Thu Jan 18 04:17:00 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279197, encodeId=b91d2e91971c, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Jan 16 21:04:14 CST 2018, time=2018-01-16, status=1, ipAttribution=)]
    2018-01-18 zhouqu_8
  9. 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    2018-01-16 thlabcde

    好资料学习了!

    0

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