Support Care Cancer：文拉法辛可减轻紫杉醇-奥沙利铂引发的急性神经毒性

2015-12-30 徐媛 MedSci原创

紫杉醇和文拉法辛引发的感觉神经毒性受剂量限制，而且大多数出现急性症状进而影响日常起居和整体生活质量。本研究的目的是评估文拉法辛治疗急性神经病变的有效性及安全性。在这项回顾性病例对照研究中，研究人员收纳了来自2010年1月至2015年2月通过奥沙利铂进行治疗的患者。依据NCI-CTCAEv.4.03等级评分评估紫杉醇和文拉法辛引发的急性神经毒性。神经毒性评估包括使用数字评定量表(NRS)测量疼痛

紫杉醇和文拉法辛引发的感觉神经毒性受剂量限制，而且大多数出现急性症状进而影响日常起居和整体生活质量。本研究的目的是评估文拉法辛治疗急性神经病变的有效性及安全性。

在这项回顾性病例对照研究中，研究人员收纳了来自2010年1月至2015年2月通过奥沙利铂进行治疗的患者。依据NCI-CTCAEv.4.03等级评分评估紫杉醇和文拉法辛引发的急性神经毒性。神经毒性评估包括使用数字评定量表(NRS)测量疼痛强度、文拉法辛治疗的减轻和神经性疼痛症状量表(NPSI)。依据HOST焦虑和抑郁量表诊断抑郁症，基于NCICTCAEv.4.03等级量表测量感觉神经毒性1-3级，基于NRS报告的≥4/10是合适的。主要结局为文拉法辛治疗缓解超过75%的症状。

本研究共纳入206名患者（82%女性，平均年龄为52.7岁），大多数患者患有乳腺癌、妇科的癌症和肠癌（93.4%）。91名患者接受文拉法辛，115名患者对照组，每3周评估1次文拉法辛。基于NRS，在文拉法辛组超过75%症状缓解的比例为53.5%、58.3%和45.2%，对照组均为0。文拉法辛组（n=7）的副作用是1-2级恶心/呕吐(3.2%)和衰弱/嗜睡(3.2%)，无3-4级事件发生。

以上研究结果显示，文拉法辛在对抗紫杉醇-奥沙利铂引发的急性感觉神经毒性有显著的临床活性。

原始出处

Kus T1, Aktas G2, Alpak G3, Kalender ME2, Sevinc A2, Kul S4, Temizer M5, Camci C2.Efficacy of venlafaxine for the relief of taxane and oxaliplatin-induced acute neurotoxicity: a single-center retrospective case-control study.Support Care Cancer. 2015 Nov 7.

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2016-01-18 ms3153534357578991

#铂#

43 0
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2016-05-03 wetgdt

#support#

61 0
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2016-01-01 12498cf9m37(暂无昵称)

#神经毒性#

52 0
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2015-12-31 wzf990214

不错哦

93 0
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2015-12-31 wzf990214

赞一个

145 0
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2015-12-31 wzf990214

有意思

130 0
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2015-12-31 wzf990214

赞一个

126 0
[GetPortalCommentsPageByObjectIdResponse(id=1737484, encodeId=6cee1e3748479, content=<a href='/topic/show?id=292f965e5b5' target=_blank style='color:#2F92EE;'>#铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96575, encryptionId=292f965e5b5, topicName=铂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca4034296500, createdName=ms3153534357578991, createdTime=Mon Jan 18 20:09:00 CST 2016, time=2016-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795205, encodeId=66ac1e952050e, content=<a href='/topic/show?id=5cd1169138f' target=_blank style='color:#2F92EE;'>#support#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16913, encryptionId=5cd1169138f, topicName=support)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Tue May 03 03:09:00 CST 2016, time=2016-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484103, encodeId=0f4914841030d, content=<a href='/topic/show?id=81c2e4343a9' target=_blank style='color:#2F92EE;'>#神经毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74343, encryptionId=81c2e4343a9, topicName=神经毒性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=42127951174, createdName=12498cf9m37(暂无昵称), createdTime=Fri Jan 01 02:09:00 CST 2016, time=2016-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50719, encodeId=41d050e198c, content=不错哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Thu Dec 31 07:05:00 CST 2015, time=2015-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50720, encodeId=45a850e2026, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Thu Dec 31 07:05:00 CST 2015, time=2015-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50721, encodeId=eb8250e2108, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Thu Dec 31 07:05:00 CST 2015, time=2015-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50722, encodeId=2cee50e22c6, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Thu Dec 31 07:05:00 CST 2015, time=2015-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50723, encodeId=ee4a50e23b9, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=189, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Thu Dec 31 07:05:00 CST 2015, time=2015-12-31, status=1, ipAttribution=)]
2015-12-31 wzf990214

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