eLife:大餐一顿后为何会想睡觉?现在终于有了一个较为科学的解释!

2016-11-26 MedSci MedSci原创

感恩节当天,美帝人们会摄入大量的火鸡、南瓜馅饼等,然后整个下午可能都会处于一个食物昏迷(指进食过多引起的倦慵感)的状态。造成此现象的原因是何,来自斯克里普斯研究所(TSRI)的研究人员在一项新的研究中揭示了其背后的机制,其研究结果已发表于eLife。 研究人员指出,所谓的食物相关的倦怠或是由于食物中的蛋白质和盐所造成的。 研究人员选用果蝇所谓研究模型,果蝇与人类有60%以上相同的DNA

感恩节当天,美帝人们会摄入大量的火鸡、南瓜馅饼等,然后整个下午可能都会处于一个食物昏迷(指进食过多引起的倦慵感)的状态。造成此现象的原因是何,来自斯克里普斯研究所(TSRI)的研究人员在一项新的研究中揭示了其背后的机制,其研究结果已发表于eLife。

研究人员指出,所谓的食物相关的倦怠或是由于食物中的蛋白质和盐所造成的。

研究人员选用果蝇所谓研究模型,果蝇与人类有60%以上相同的DNA,且研究表明,75%左右的人类疾病基因同样存在于果蝇中。因此,果蝇被认为是科学研究的理想模型。

研究人员研发了一种称为Activity Recording CAFE(ARC)的系统,使得他们能够测量果蝇活进食前后的活动情况。


ARC系统显示,果蝇在大吃一顿后出现了与人类相似的睡眠行为,睡眠了约20-40分钟。此外,研究人员发现,果蝇摄入的食物越多,其睡眠时间越久。

进一步研究中,研究人员发现,机体对睡眠的需求增加是由于蛋白质和盐的摄入量所驱动的,而糖的摄入量却并没有影响睡眠的需求。

研究的下一步,研究人员将尝试探究食物的摄入对大脑触发餐后疲劳的影响机制。

既往研究已经表明,称为白细胞激肽(LK)的神经细胞,或神经元,在控制机体摄食量上发挥着作用,这表明LK神经元在机体摄食时会变得很活跃以改变机体的摄食行为。

事实上,通过基因手段激活和失活果蝇的神经元,研究人员发现,LK神经元在机体大餐一顿后的机体疲劳中发挥着作用。

总的来说,研究人员认为ARC模型在解释机体为何大餐以后会感觉疲劳中提供了新的见解。

原始出处:


William Ja et al.,Postprandial sleep mechanics in Drosophila, eLife. 22 November 2016.

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    2017-11-10 膀胱癌
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    2017-04-19 clmlylxy
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    2016-11-27 现在

    课题老旧

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Nov 27 05:58:10 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158390, encodeId=da09158390b0, content=学习起来了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib0kbzef1jKfxVxKKxoGdVMdMe54JuaABgJlOdkfVdUkxEReXZyZ0PMHhxlzMkiciaPAp2gJsoIbGKtA/0, createdBy=a2d51960177, createdName=komasun, createdTime=Sun Nov 27 02:14:13 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158342, encodeId=d3a9158342b3, content=下一步是不是该探究下饱暖思淫欲了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sat Nov 26 18:41:31 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158331, encodeId=ff491583318a, content=这次知道为啥了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c551986141, createdName=平凡之路0255, createdTime=Sat Nov 26 17:09:02 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158320, encodeId=ff8215832098, content=受益匪浅,认真学习了,好文值得点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Nov 26 17:00:21 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-11-27 tsing_hit
  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sat Nov 26 18:41:31 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158331, encodeId=ff491583318a, content=这次知道为啥了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c551986141, createdName=平凡之路0255, createdTime=Sat Nov 26 17:09:02 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158320, encodeId=ff8215832098, content=受益匪浅,认真学习了,好文值得点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Nov 26 17:00:21 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-11-27 老段

    …学习了,赞一下

    0

  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Nov 27 05:58:10 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158390, encodeId=da09158390b0, content=学习起来了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib0kbzef1jKfxVxKKxoGdVMdMe54JuaABgJlOdkfVdUkxEReXZyZ0PMHhxlzMkiciaPAp2gJsoIbGKtA/0, createdBy=a2d51960177, createdName=komasun, createdTime=Sun Nov 27 02:14:13 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158342, encodeId=d3a9158342b3, content=下一步是不是该探究下饱暖思淫欲了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sat Nov 26 18:41:31 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158331, encodeId=ff491583318a, content=这次知道为啥了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c551986141, createdName=平凡之路0255, createdTime=Sat Nov 26 17:09:02 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158320, encodeId=ff8215832098, content=受益匪浅,认真学习了,好文值得点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Nov 26 17:00:21 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-11-27 1e145228m78(暂无匿称)

    zr习

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Nov 26 17:00:21 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-11-27 komasun

    学习起来了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1972976, encodeId=b87619e29761e, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Fri Nov 10 22:53:00 CST 2017, time=2017-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068476, encodeId=209d20684e6b9, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Nov 27 05:58:10 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158390, encodeId=da09158390b0, content=学习起来了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib0kbzef1jKfxVxKKxoGdVMdMe54JuaABgJlOdkfVdUkxEReXZyZ0PMHhxlzMkiciaPAp2gJsoIbGKtA/0, createdBy=a2d51960177, createdName=komasun, createdTime=Sun Nov 27 02:14:13 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158342, encodeId=d3a9158342b3, content=下一步是不是该探究下饱暖思淫欲了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sat Nov 26 18:41:31 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158331, encodeId=ff491583318a, content=这次知道为啥了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c551986141, createdName=平凡之路0255, createdTime=Sat Nov 26 17:09:02 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158320, encodeId=ff8215832098, content=受益匪浅,认真学习了,好文值得点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Nov 26 17:00:21 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-11-26 xiaotaiyang1

    下一步是不是该探究下饱暖思淫欲了?

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1972976, encodeId=b87619e29761e, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Fri Nov 10 22:53:00 CST 2017, time=2017-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068476, encodeId=209d20684e6b9, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Nov 27 05:58:10 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158390, encodeId=da09158390b0, content=学习起来了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib0kbzef1jKfxVxKKxoGdVMdMe54JuaABgJlOdkfVdUkxEReXZyZ0PMHhxlzMkiciaPAp2gJsoIbGKtA/0, createdBy=a2d51960177, createdName=komasun, createdTime=Sun Nov 27 02:14:13 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158342, encodeId=d3a9158342b3, content=下一步是不是该探究下饱暖思淫欲了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sat Nov 26 18:41:31 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158331, encodeId=ff491583318a, content=这次知道为啥了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c551986141, createdName=平凡之路0255, createdTime=Sat Nov 26 17:09:02 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158320, encodeId=ff8215832098, content=受益匪浅,认真学习了,好文值得点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Nov 26 17:00:21 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-11-26 平凡之路0255

    这次知道为啥了。

    0

  10. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sat Nov 26 18:41:31 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158331, encodeId=ff491583318a, content=这次知道为啥了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c551986141, createdName=平凡之路0255, createdTime=Sat Nov 26 17:09:02 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158320, encodeId=ff8215832098, content=受益匪浅,认真学习了,好文值得点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Nov 26 17:00:21 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-11-26 ylzr123

    受益匪浅,认真学习了,好文值得点赞!

    0

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