JAHA:口腔微生物组与绝经后妇女高血压有关

2022-03-02 MedSci原创 MedSci原创

特定的口腔细菌与绝经后妇女的基线血压状态和高血压发生风险相关。需要进行研究以确定这些观察性结果并阐明其机制。

口腔微生物群被认为会影响血压调节。然而,支持这一假设的流行病学数据十分有限。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员评估了绝经后妇女口腔微生物群、血压和高血压之间的关联。

研究人员对1215名女性(平均年龄为63岁)完成基线(1997-2001)评估,在此期间收集了受试者龈下菌斑,并测量了血压,以及获得医疗和生活方式史和药物清单。研究人员使用16S核糖体RNA基因扩增子测序测量了受试者龈下菌斑的微生物组组成。基线测量的血压定义为血压正常(收缩压<120mmHg和舒张压<80mmHg,不使用血压药物;n=429);升高(收缩压≥120mmHg或舒张压≥80mmHg,未使用药物;n=306);或患有需要治疗的高血压(医生诊断且接受药物治疗的病史;n=480)。高血压(735例未接受基线治疗的高血压患者中的375例)被定义为年度健康调查报告(平均随访时间为10.4年)中新近诊断需要接受药物治疗的高血压。

研究人员通过横断面分析确定了47种细菌(共245种)会根据基线血压状态而存在显著差异(P<0.05)。前瞻性分析确定了15种基线细菌种类(P<0.05)与高血压事件显著相关(P<0.05):10种与之呈正相关(年龄调整风险比[HRs]为1.10-1.16/SD)和5种与之呈负相关(HRs为0.82-0.91)。在进一步调整人口统计学、临床和生活方式因素后,相关性基本没有变化;当分析仅限于血压正常组时,获得了相似的结果;并且在基线年龄、吸烟、体重指数和血压类别的各组之间具有一致的量级。

由此可见,特定的口腔细菌与绝经后妇女的基线血压状态和高血压发生风险相关。需要进行研究以确定这些观察性结果并阐明其机制。

原始出处:

Michael J. LaMonte.et al.Oral Microbiome Is Associated With Incident Hypertension Among Postmenopausal Women.JAHA.2022.https://www.ahajournals.org/doi/full/10.1161/JAHA.121.021930

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    2022-03-09 D-House

    学习

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    2022-03-09 D-House

    牛逼

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    2022-03-04 zhaohui6731
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    2022-03-04 zxxiang
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