Int J Cardiol:高尿酸血症对心血管疾病风险的预测情况!

2017-05-14 MedSci MedSci原创

患者在不同状况下,高尿酸血症与患心血管疾病有关。该研究测试了Cox模型中的尿酸(UA)(包括标准危险因素在内)是否能够使1,522名初治高血压患者的心血管风险更好地分层,并保留患者肾功能。

患者在不同状况下,高尿酸血症与患心血管疾病有关。该研究测试了Cox模型中的尿酸(UA)(包括标准危险因素在内)是否能够使1,522名初治高血压患者的心血管风险更好地分层,并保留患者肾功能。该研究使用多个Cox回归模型来评估UA对心血管结局的独立影响,并且评估UA作为Harrell'C指数,净重分类指数(NRI)和  综合歧视改善(IDI)额外预后价值的指标的效果,除此之外,明确UA在提供标准危险因素和估计的肾小球滤过率(e-GFR)方面的作用。研究主要关注点是1)致命的和非致命的心血管事件;2)致命和非致命的冠状动脉结局(由于其他心血管事件的死亡)。结果显示,在未经调整的Cox回归分析中,UA与两项结果密切相关(P <0.001)。将UA纳入包括Framingham风险因子和e-GFR在内的多个Cox回归模型中不影响UA与研究结局之间的关联(致命和非致死性心血管事件,HR = 1.44,95%CI = 1.36-1.55,P <0.001;致命和非致死性冠状动脉结局/其他心血管事件死亡,HR = 1.48,95%CI = 1.36-1.61,P <0.001

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    2017-05-23 方舒

    学习

    0

  3. 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    2017-05-22 方舒

    学习

    0

  4. 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href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Tue May 16 11:17:00 CST 2017, time=2017-05-16, status=1, ipAttribution=)]
    2017-05-19 cuiyejia

    学习了,谢谢

    0

  5. 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    2017-05-18 137****4081

    这是必须注意的一项指标数,这文章还是很有意义

    0

  6. 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    2017-05-17 大爰

    学习并分享!!!

    0

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    2017-05-16 皇家骑士团团尾

    痛风 代谢综合征

    0

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