JAHA:盐皮质激素受体拮抗剂可改善部分心梗和心衰患者预后

2018-07-07 MedSci MedSci原创

目前,关于盐皮质激素受体拮抗剂(MRA)对心梗和心衰患者预后的影响尚不清楚。本研究的目的旨在评估MRA对伴有心衰的心梗患者预后的影响及其与左室射血分数(LVEF)和慢性肾脏疾病的关系。本研究纳入了2005-2014年瑞典数据库中的45071名伴有心衰的心梗患者,其中4470名(9.9%)患者接受了MRA治疗,经过3年时间的随访,与LVEF 40%-49% (9.1%) 或LVEF ≥50% (4.

目前,关于盐皮质激素受体拮抗剂(MRA)对心梗和心衰患者预后的影响尚不清楚。本研究的目的旨在评估MRA对伴有心衰的心梗患者预后的影响及其与左室射血分数(LVEF)和慢性肾脏疾病的关系。

本研究纳入了2005-2014年瑞典数据库中的45071名伴有心衰的心梗患者,其中4470名(9.9%)患者接受了MRA治疗,经过3年时间的随访,与LVEF 40%-49% (9.1%) 或LVEF ≥50% (4.7%)的患者相比,LVEF <40%的患者接受MRA治疗的概率更大,在有慢性肾脏疾病的患者中,有8.6%的患者接受了MRA治疗。经多变量调整分析后,MRA治疗与LVEF <40%(HR [95% Cl] 0.81 [0.75-0.88])和LVEF 40%-49%(HR:0.88 [0.75-1.03])患者死亡率的下降呈相关性,且MRA与LVEF强相关(P<0.0001)。另外,MRA与死亡率的关系在有无慢性肾脏疾病患者中相似。

本研究结果显示,在患有心衰和心梗的患者中,盐皮质激素受体拮抗剂可提高左室射血分数<40%的患者的远期生存率。

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    2018-07-09 大爰

    学习了谢谢分享!!

    0

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    2018-07-09 zhaohui6731
  5. 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channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Jul 07 12:09:01 CST 2018, time=2018-07-07, status=1, ipAttribution=)]
  8. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Sat Jul 07 13:42:17 CST 2018, time=2018-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329988, encodeId=b22332998872, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Jul 07 12:55:08 CST 2018, time=2018-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329972, encodeId=66eb3299e240, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Jul 07 12:09:01 CST 2018, time=2018-07-07, status=1, ipAttribution=)]
    2018-07-07 张新亮1853311252142e2fm

    好文献学习了

    0

  9. 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channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Jul 07 12:09:01 CST 2018, time=2018-07-07, status=1, ipAttribution=)]
    2018-07-07 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

  10. 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channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Jul 07 12:09:01 CST 2018, time=2018-07-07, status=1, ipAttribution=)]
    2018-07-07 虈亣靌

    学习学习学习

    0

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