Am J Gastroenterol:维生素D和NAFLD的严重程度无关

2016-10-05 Mechront 译 MedSci原创

根据公布的调查结果,缺乏维生素D与非酒精性脂肪性肝病(NAFLD)的严重程度不相关。 杜克大学医学中心的胃肠病和肝病科的Yuval A. Patel博士称:据williamhill asia 所知,这是第一个关于血清25羟维生素D水平和肝脏的表达维生素D代谢基因与NAFLD严重程度的研究;对活检证实NAFLD患者进行的横断面分析中,williamhill asia 没有发现维生素D与NAFLD诊断或组织学严重程度之间的关联。 Patel尔和他的

根据公布的调查结果,缺乏维生素D与非酒精性脂肪性肝病(NAFLD)的严重程度不相关。

杜克大学医学中心的胃肠病和肝病科的Yuval A. Patel博士称:据williamhill asia 所知,这是第一个关于血清25羟维生素D水平和肝脏的表达维生素D代谢基因与NAFLD严重程度的研究;对活检证实NAFLD患者进行的横断面分析中,williamhill asia 没有发现维生素D与NAFLD诊断或组织学严重程度之间的关联。

Patel尔和他的同事们对283个研究对象进行了分析研究,其中227个白人、45个黑人、9个西班牙裔人、2个亚洲人。这项研究包括244例NAFLD患者,余下的为对照组。研究人员指出,对照组肝活检没有发现NAFLD;两组在维生素D补充剂的使用、体重指数、性别和年龄方面均具有可比性。

研究人员发现,NAFLD患者更有可能存在更高的糖化血红蛋白水平(6.5 ± 1.2 vs. 5.9 ± 1; P = .009);来自代谢和减肥手术计划的患者更不可能存在脂肪肝活检证实NAFLD (P = .008);此外,Patel和同事们发现,NAFLD组患者和对照组参与者的25羟基维生素D水平没有差异(27.6 ± 11.8 ng/mL vs. 27.9 ± 12.8 ng/mL; P = .88)。

研究人员写道,以下参与者的维生素D水平更高:使用维生素D补充剂(n = 93; 31.2 ± 13.0 vs. 25.9 ± 10.9; P = .0003)、肤色浅(28.4 ± 11.6 vs. 24.6 ± 12.8; P = .039)。研究人员还指出,与深肤色参与者相比,浅肤色的NAFLD比例更大(与对照组相比)(83.6% vs. 64.1%; P = .005)。

原始出处:


No link between vitamin D deficiency, NAFLD severity.Healio.October 4, 2016

Patel YA, et al. Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis.Am J Gastroenterol. 2016:doi:10.1038/ajg.2016.406.

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    2016-12-25 lvygwyt2781
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    2016-10-19 hb2008ye
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    2017-07-12 许安
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    2016-10-11 知难而进

    继续关注!

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  6. [GetPortalCommentsPageByObjectIdResponse(id=2083896, encodeId=ceda2083896a7, content=<a href='/topic/show?id=d3b820e32c' target=_blank style='color:#2F92EE;'>#AFLD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2073, encryptionId=d3b820e32c, topicName=AFLD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=947269, createdName=lvygwyt2781, createdTime=Sun Dec 25 03:27:00 CST 2016, time=2016-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064011, encodeId=bef120640116b, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Mon Jan 16 00:27:00 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710935, encodeId=a7421e10935fc, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Wed Oct 19 14:27:00 CST 2016, time=2016-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071676, encodeId=600b20e16760a, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Wed Jul 12 02:27:00 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146111, encodeId=a37a14611134, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 22:39:13 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146109, encodeId=da00146109ef, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 22:39:04 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141450, encodeId=f84a14145078, content=好好看下, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri Oct 07 09:59:49 CST 2016, time=2016-10-07, status=1, ipAttribution=)]
    2016-10-11 知难而进

    谢谢分享!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2083896, encodeId=ceda2083896a7, content=<a href='/topic/show?id=d3b820e32c' target=_blank style='color:#2F92EE;'>#AFLD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2073, encryptionId=d3b820e32c, topicName=AFLD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=947269, createdName=lvygwyt2781, createdTime=Sun Dec 25 03:27:00 CST 2016, time=2016-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064011, encodeId=bef120640116b, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Mon Jan 16 00:27:00 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710935, encodeId=a7421e10935fc, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Wed Oct 19 14:27:00 CST 2016, time=2016-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071676, encodeId=600b20e16760a, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Wed Jul 12 02:27:00 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146111, encodeId=a37a14611134, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 22:39:13 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146109, encodeId=da00146109ef, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 22:39:04 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141450, encodeId=f84a14145078, content=好好看下, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri Oct 07 09:59:49 CST 2016, time=2016-10-07, status=1, ipAttribution=)]
    2016-10-07 忠诚向上

    好好看下

    0

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