如何从Science文章中挖掘出新方向

2015-07-17 四月23 GCBI

经常拜读大牛们发表的Science和Nature,但是williamhill asia 可不可以从这些文章中学到精髓,也来发表一篇高分论文呢? 举个例子,比方说发表在Science上的这篇文章The STAT3-Binding Long Noncoding RNA lnc-DC Controls Human Dendritic Cell Differentiation,williamhill asia 得知:抑制lnc-DC可破坏体外人类外周血单

经常拜读大牛们发表的Science和Nature,但是williamhill asia 可不可以从这些文章中学到精髓,也来发表一篇高分论文呢?

举个例子,比方说发表在Science上的这篇文章The STAT3-Binding Long Noncoding RNA lnc-DC Controls Human Dendritic Cell Differentiation,williamhill asia 得知:抑制lnc-DC可破坏体外人类外周血单核细胞以及体内的小鼠骨髓细胞分化为DC,并减小了DCs刺激T细胞活化能力。lnc-DC通过激活转录因子STAT3来调节这些效应,lnc-DC直接结合细胞质中的STAT3上,通过阻止STAT3结合SHP1及脱磷酸作用,提高STAT3在tyrosine-705上磷酸化。这篇文章主要涉及的内容有树突状细胞的分化和功能,来搜索一下“Dendritic cell differentiation and function”,搜索结果很多,可以设置“影响因子”和“是否拥有样本”缩小范围来进行下一步筛选。如果只是简单的翻阅文章可能理解的还不够深入,williamhill asia 可以使用文章提供的样本来还原作者的实验思路,甚至还有可能发现更多。


图1 搜索结果及筛选工具

图2 Science文章及样本界面

OK,就看Science这篇文章,文章和样本中提到Monocytes经过6个时间点分化为Dendritic Cell,而这批数据通过HTA 2.0芯片检测可获得mRNA、lncRNA表达数据。根据从GCBI-Sample下载的数据(GSE54143),首先williamhill asia 可以分析mRNA、lncRNA随分化时间而发生表达变化的趋势,同时对mRNA进行GO、Pathway分析,不仅如此,williamhill asia 还可以分析lncRNA调控mRNA的共表达网络,找到核心调控lncRNA和mRNA。


图3 拓展分析思路图

运行方案后稍等10-20分钟,就可以查看各部分详细结果并下载完整的结果报告。结果很多,包括刚才提到的显著mRNA、lncRNA及其趋势等,而在共表达网络图部分发现一些核心基因CCL22、TFRC、SELL、IL23A、FOSB。


图4 lncRNA和mRNA共表达网络图

这些基因不了解没关系,接下来再回到知识库以Immune为关键词检索文献,发现共有905027篇,而与刚才提到的基因相关的文献分别为:CCL22(36篇)、TFRC(20篇)、SELL(106篇)、IL23A(176篇),而FOSB只有3篇。通过Dictionary查询,发现FOSB参与破骨细胞分化信号通路,样本为诱导单核细胞分化为树突状细胞,bingo!然而在microRNA部分只有has-miR-224-5p已经被验证过,由于最近ceRNA研究很热,这可以作为下一个研究课题。

好的,williamhill asia 来梳理一下:文章提到了转录因子STAT3和lnc-DC之间的关系,通过对数据的挖掘再分析,发现核心基因FOSB以及相关miRNA,而这些都是文章没有提到同时研究很少,那么williamhill asia 是不是可以做点什么了?

版权声明:
本网站所有内容来源注明为“williamhill asia 医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于williamhill asia 医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“williamhill asia 医学”。其它来源的文章系转载文章,或“williamhill asia 号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与williamhill asia 联系,williamhill asia 将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=256478, encodeId=3b9e2564e86d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJNCjP5GJqqBZFlbk1Dm8cXyP7gpY57Ut698B6phuTyicrxr4kcWYkhhCCeAmco6PFOMa0JSribUP9A/0, createdBy=cfcb2174142, createdName=wangvase, createdTime=Fri Oct 27 23:00:00 CST 2017, time=2017-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=89581, encodeId=07ed8958130, content=好深奥, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b9d01623203, createdName=wuxclove, createdTime=Sun Jun 12 14:58:00 CST 2016, time=2016-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41601, encodeId=261a4160125, content=不理解,基础还是不足, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Tue Oct 27 20:35:00 CST 2015, time=2015-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33129, encodeId=cd0933129a4, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIKlpu9buib1TxXRibfFuzYXHaLxQgfUpwzYwTMo8551BS40KVZNRDLWmAXSibjfnFm0QggOrCSWElfw/132, createdBy=95aa1617853, createdName=happy1, createdTime=Sun Jul 19 22:38:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375071, encodeId=26c113e50711e, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sun Jul 19 08:41:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33078, encodeId=85b4330e85b, content=方向在哪, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Sun Jul 19 00:01:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33015, encodeId=69fe330157d, content=哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Fri Jul 17 22:53:00 CST 2015, time=2015-07-17, status=1, ipAttribution=)]
    2017-10-27 wangvase

    学习了

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=256478, encodeId=3b9e2564e86d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJNCjP5GJqqBZFlbk1Dm8cXyP7gpY57Ut698B6phuTyicrxr4kcWYkhhCCeAmco6PFOMa0JSribUP9A/0, createdBy=cfcb2174142, createdName=wangvase, createdTime=Fri Oct 27 23:00:00 CST 2017, time=2017-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=89581, encodeId=07ed8958130, content=好深奥, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b9d01623203, createdName=wuxclove, createdTime=Sun Jun 12 14:58:00 CST 2016, time=2016-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41601, encodeId=261a4160125, content=不理解,基础还是不足, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Tue Oct 27 20:35:00 CST 2015, time=2015-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33129, encodeId=cd0933129a4, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIKlpu9buib1TxXRibfFuzYXHaLxQgfUpwzYwTMo8551BS40KVZNRDLWmAXSibjfnFm0QggOrCSWElfw/132, createdBy=95aa1617853, createdName=happy1, createdTime=Sun Jul 19 22:38:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375071, encodeId=26c113e50711e, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sun Jul 19 08:41:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33078, encodeId=85b4330e85b, content=方向在哪, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Sun Jul 19 00:01:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33015, encodeId=69fe330157d, content=哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Fri Jul 17 22:53:00 CST 2015, time=2015-07-17, status=1, ipAttribution=)]
    2016-06-12 wuxclove

    好深奥

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=256478, encodeId=3b9e2564e86d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJNCjP5GJqqBZFlbk1Dm8cXyP7gpY57Ut698B6phuTyicrxr4kcWYkhhCCeAmco6PFOMa0JSribUP9A/0, createdBy=cfcb2174142, createdName=wangvase, createdTime=Fri Oct 27 23:00:00 CST 2017, time=2017-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=89581, encodeId=07ed8958130, content=好深奥, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b9d01623203, createdName=wuxclove, createdTime=Sun Jun 12 14:58:00 CST 2016, time=2016-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41601, encodeId=261a4160125, content=不理解,基础还是不足, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Tue Oct 27 20:35:00 CST 2015, time=2015-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33129, encodeId=cd0933129a4, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIKlpu9buib1TxXRibfFuzYXHaLxQgfUpwzYwTMo8551BS40KVZNRDLWmAXSibjfnFm0QggOrCSWElfw/132, createdBy=95aa1617853, createdName=happy1, createdTime=Sun Jul 19 22:38:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375071, encodeId=26c113e50711e, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sun Jul 19 08:41:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33078, encodeId=85b4330e85b, content=方向在哪, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Sun Jul 19 00:01:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33015, encodeId=69fe330157d, content=哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Fri Jul 17 22:53:00 CST 2015, time=2015-07-17, status=1, ipAttribution=)]
    2015-10-27 三三五五

    不理解,基础还是不足

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=256478, encodeId=3b9e2564e86d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJNCjP5GJqqBZFlbk1Dm8cXyP7gpY57Ut698B6phuTyicrxr4kcWYkhhCCeAmco6PFOMa0JSribUP9A/0, createdBy=cfcb2174142, createdName=wangvase, createdTime=Fri Oct 27 23:00:00 CST 2017, time=2017-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=89581, encodeId=07ed8958130, content=好深奥, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b9d01623203, createdName=wuxclove, createdTime=Sun Jun 12 14:58:00 CST 2016, time=2016-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41601, encodeId=261a4160125, content=不理解,基础还是不足, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Tue Oct 27 20:35:00 CST 2015, time=2015-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33129, encodeId=cd0933129a4, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIKlpu9buib1TxXRibfFuzYXHaLxQgfUpwzYwTMo8551BS40KVZNRDLWmAXSibjfnFm0QggOrCSWElfw/132, createdBy=95aa1617853, createdName=happy1, createdTime=Sun Jul 19 22:38:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375071, encodeId=26c113e50711e, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sun Jul 19 08:41:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33078, encodeId=85b4330e85b, content=方向在哪, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Sun Jul 19 00:01:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33015, encodeId=69fe330157d, content=哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Fri Jul 17 22:53:00 CST 2015, time=2015-07-17, status=1, ipAttribution=)]
    2015-07-19 happy1

    好文章

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=256478, encodeId=3b9e2564e86d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJNCjP5GJqqBZFlbk1Dm8cXyP7gpY57Ut698B6phuTyicrxr4kcWYkhhCCeAmco6PFOMa0JSribUP9A/0, createdBy=cfcb2174142, createdName=wangvase, createdTime=Fri Oct 27 23:00:00 CST 2017, time=2017-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=89581, encodeId=07ed8958130, content=好深奥, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b9d01623203, createdName=wuxclove, createdTime=Sun Jun 12 14:58:00 CST 2016, time=2016-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41601, encodeId=261a4160125, content=不理解,基础还是不足, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Tue Oct 27 20:35:00 CST 2015, time=2015-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33129, encodeId=cd0933129a4, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIKlpu9buib1TxXRibfFuzYXHaLxQgfUpwzYwTMo8551BS40KVZNRDLWmAXSibjfnFm0QggOrCSWElfw/132, createdBy=95aa1617853, createdName=happy1, createdTime=Sun Jul 19 22:38:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375071, encodeId=26c113e50711e, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sun Jul 19 08:41:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33078, encodeId=85b4330e85b, content=方向在哪, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Sun Jul 19 00:01:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33015, encodeId=69fe330157d, content=哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Fri Jul 17 22:53:00 CST 2015, time=2015-07-17, status=1, ipAttribution=)]
    2015-07-19 jichang
  6. [GetPortalCommentsPageByObjectIdResponse(id=256478, encodeId=3b9e2564e86d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJNCjP5GJqqBZFlbk1Dm8cXyP7gpY57Ut698B6phuTyicrxr4kcWYkhhCCeAmco6PFOMa0JSribUP9A/0, createdBy=cfcb2174142, createdName=wangvase, createdTime=Fri Oct 27 23:00:00 CST 2017, time=2017-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=89581, encodeId=07ed8958130, content=好深奥, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b9d01623203, createdName=wuxclove, createdTime=Sun Jun 12 14:58:00 CST 2016, time=2016-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41601, encodeId=261a4160125, content=不理解,基础还是不足, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Tue Oct 27 20:35:00 CST 2015, time=2015-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33129, encodeId=cd0933129a4, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIKlpu9buib1TxXRibfFuzYXHaLxQgfUpwzYwTMo8551BS40KVZNRDLWmAXSibjfnFm0QggOrCSWElfw/132, createdBy=95aa1617853, createdName=happy1, createdTime=Sun Jul 19 22:38:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375071, encodeId=26c113e50711e, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sun Jul 19 08:41:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33078, encodeId=85b4330e85b, content=方向在哪, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Sun Jul 19 00:01:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33015, encodeId=69fe330157d, content=哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Fri Jul 17 22:53:00 CST 2015, time=2015-07-17, status=1, ipAttribution=)]
    2015-07-19 sanshengshi

    方向在哪

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=256478, encodeId=3b9e2564e86d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJNCjP5GJqqBZFlbk1Dm8cXyP7gpY57Ut698B6phuTyicrxr4kcWYkhhCCeAmco6PFOMa0JSribUP9A/0, createdBy=cfcb2174142, createdName=wangvase, createdTime=Fri Oct 27 23:00:00 CST 2017, time=2017-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=89581, encodeId=07ed8958130, content=好深奥, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b9d01623203, createdName=wuxclove, createdTime=Sun Jun 12 14:58:00 CST 2016, time=2016-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41601, encodeId=261a4160125, content=不理解,基础还是不足, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Tue Oct 27 20:35:00 CST 2015, time=2015-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33129, encodeId=cd0933129a4, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIKlpu9buib1TxXRibfFuzYXHaLxQgfUpwzYwTMo8551BS40KVZNRDLWmAXSibjfnFm0QggOrCSWElfw/132, createdBy=95aa1617853, createdName=happy1, createdTime=Sun Jul 19 22:38:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375071, encodeId=26c113e50711e, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sun Jul 19 08:41:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33078, encodeId=85b4330e85b, content=方向在哪, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Sun Jul 19 00:01:00 CST 2015, time=2015-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33015, encodeId=69fe330157d, content=哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ee51614674, createdName=240612799, createdTime=Fri Jul 17 22:53:00 CST 2015, time=2015-07-17, status=1, ipAttribution=)]
    2015-07-17 240612799

    0

相关威廉亚洲官网

中国机构CNS月报(2014年11月)

自然系列期刊在2012年的论文统计显示,发文140篇论文的中国科学院超过日本东京大学排名亚洲机构第一位,这也是Nature Index统计以来中国科研机构首次排名第一,反映出中国顶尖科研机构在数量上领跑亚洲。据生物探索统计,2014年11月份中国科研机构在Nature、Cell和Science三大系列期刊的总发文量是62篇,比上月低10篇。

2014年中医最后一件大事,Science杂志给中医发了个专刊

开篇世界卫生组织的总干事Margaret Chan博士谈:支持传统医学的现代化和一体化。 “近四分之一的药物来自于天然药物,而其中许多都是中医首次使用”。 AAAS的CEO、Science杂志出品人Alan Leshner博士:传统医学的中间路线。 “传统医学的研究者正在试图通过现代组学和最新的技术来规范传统治疗方法” 专刊文章论述依次是: The WHO T

传统中药登上世界舞台 Science杂志刊登麝香保心丸研究成果

图 Science 杂志刊登麝香保心丸研究成果 传统中药登上世界舞台2015年1月16日,世界权威学术杂志之一——《科学》(Science)在其中医药专刊中对麝香保心丸的研究成果进行了专题报道[Science 2015, 347(6219sppl),S40,图]。Science杂志是美国科学促进会(AmericanAssociation for theAdvancement of Sci

Science 公布2014年度十大科学突破

据《科学》杂志编辑披露,罗塞塔飞船在今年8月追上了火星之外的被称作67P/Churyumov-Gerasimenko的彗星,而其获得的初步成果——连同它在不久的将来进行的研究——使其跃居今年最重要科学突破的名单之首。这一年度突破性科学成就名单是由《科学》杂志及其出版方,国际性的非营利机构美国科学促进会(AAAS)选出的,它还包括了在医学、机器人技术、合成生物学和古生物学(仅举数例)方面所取得的

Science:危险!命悬一线的儿童研究

在美国威斯康星州密尔沃基市西郊一套租用的办公室里,Durkin和她的15名员工、耗费了7年时间、花费了1600万美元,正预备在瓦克夏县招募1250名孕妇,这些即将出生的婴儿将成为后续10万名婴儿的一部分,共同参与有史以来最大规模、最长期的美国儿童健康研究项目。但与预期相反的是,仅仅在Durkin招募了200名女性的试点阶段后,美国国立卫生研究院(NIH)告知她,接下来,私人承包商将会接手她的部

Science Advances正式创刊

在Nature发行了几十份子刊后,Science终于坐不住了,继多年前“犹抱琵琶半遮面”地推出Signaling和Transnational Medicine后,本月又正式宣布Advances创刊,并计划于明年2月发表第一篇文章。 Science Advances将只有电子版,而且是开放获取,这就意味着要求作者付费发表。看起来它的编辑方针与发行模式跟PLoS ONE差不多,比如发文范围极其广泛,几