Diabetes:代谢产物与胰岛素抵抗密切相关

2012-05-06 佚名 糖尿病手机报第11期

  芬兰一项研究报告,氨基酸、葡萄糖合成中间产物、酮体、脂肪酸等20种代谢物与胰岛素抵抗相关性。研究4月17日在线发表于《糖尿病》(Diabetes)杂志。   该研究纳入7098名芬兰人,对胰岛素抵抗相关代谢产物进行分析。支链和芳香族氨基酸、糖异生中间产物、酮体以及脂肪酸成分和饱和度与稳态模型胰岛素抵抗指数(HOMA-IR)相关,亮氨酸、异亮氨酸、缬氨酸、酪氨酸在异常肥胖的女性中显著增多。与1

  芬兰一项研究报告,氨基酸、葡萄糖合成中间产物、酮体、脂肪酸等20种代谢物与胰岛素抵抗相关性。研究4月17日在线发表于《糖尿病》(Diabetes)杂志。

  该研究纳入7098名芬兰人,对胰岛素抵抗相关代谢产物进行分析。支链和芳香族氨基酸、糖异生中间产物、酮体以及脂肪酸成分和饱和度与稳态模型胰岛素抵抗指数(HOMA-IR)相关,亮氨酸、异亮氨酸、缬氨酸、酪氨酸在异常肥胖的女性中显著增多。与12种代谢产物有关的GCKR变异亦与HOMA-IR相关。在年轻人群中,除了反映肥胖和脂质异常之外的其他代谢标志物,反映了胰岛素抵抗的程度。



    

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    2012-06-06 baoya
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