SCI REP:甲状腺功能正常的2型糖尿病患者甲状腺激素水平与糖尿病肾病的关系!

2018-03-17 xing.T MedSci原创

目前的研究表明,FT3水平在正常范围内与T2DM患者DKD呈负相关。

甲状腺功能正常和糖尿病肾病(DKD)之间的关联已经获得了越来越多的关注。近日,Scientific reports杂志上发表了一篇研究文章,该研究评估了正常甲状腺激素水平与2型糖尿病(T2DM)患者DKD之间的关系。

该研究共有862例2型糖尿病患者参与这个在中国西安完成的横断面研究。受试者进行人体学指标、甲状腺功能和DKD的评估。

在862例患者中,246例(28.5%)患有DKD,DKD患病率在男性和女性之间没有差异。在基于游离三碘甲状腺原氨酸(FT3)水平的四分位数中DKD患病率呈明显下降趋势(41.1%、30.6%、23.8%和18.9%,P<0.001)。在所有的参与者都与归类于FT3水平处于第1四分位数(FT3-Q1)的受试者进行比较(P<4.380),第2(FT2-Q1)、第3(FT3-Q1)和第4(FT4-Q1)四分位数的受试者DKD调整后的比值比分别为0.655(95%可信区间:0.406–1.057)、0.493(95%可信区间:0.299–0.813),0.406(95%可信区间:0.237–0.697)(P<0.05)。此外,在男性中也观察到类似的结果。相反,在女性中,FT3组均与DKD无关。

目前的研究表明,FT3水平在正常范围内与T2DM患者DKD呈负相关。

原始出处:


Jian Zou,et al. Association between Thyroid Hormone Levels and Diabetic Kidney Disease in Euthyroid Patients with Type 2 Diabetes.Scientific reports.2018. https://www.nature.com/articles/s41598-018-22904-7

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beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sun Mar 18 21:56:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297402, encodeId=20c129e4028e, content=学习糖尿病知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sun Mar 18 11:43:56 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297079, encodeId=e89429e079a7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sat Mar 17 10:13:58 CST 2018, time=2018-03-17, status=1, ipAttribution=)]
    2018-03-22 jyzxjiangqin

    甲状腺功能正常的2型糖尿病.

    0

  5. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sun Mar 18 21:56:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297402, encodeId=20c129e4028e, content=学习糖尿病知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sun Mar 18 11:43:56 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297079, encodeId=e89429e079a7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sat Mar 17 10:13:58 CST 2018, time=2018-03-17, status=1, ipAttribution=)]
    2018-03-20 青山颖钰

    学习了.谢谢啦

    0

  6. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sun Mar 18 21:56:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297402, encodeId=20c129e4028e, content=学习糖尿病知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sun Mar 18 11:43:56 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297079, encodeId=e89429e079a7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sat Mar 17 10:13:58 CST 2018, time=2018-03-17, status=1, ipAttribution=)]
    2018-03-20 飘飘爱

    很好

    0

  7. 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  8. 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  9. 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    2018-03-18 flysky120

    学习糖尿病知识了

    0

  10. 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    2018-03-17 yfjms

    学习

    0

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