Int J Impot Res:精液中的活性氧种类水平与阴茎勃起功能相关

2018-08-14 AlexYang MedSci原创

慢性前列腺炎/慢性盆腔疼痛综合症(CP/CPPS)经常与阴茎勃起功能障碍(ED)相关。然而,ED发生的潜在病理生理学机制在患有CP/CPPS的患者中仍旧不清楚。最近,有研究人员调查了超氧阴离子和总活性氧种类在IIIA类CP/CPPS男性患者的精液中的产生情况,并调查了其与ED的相关性。他们的前瞻性研究包括了33名患有IIIA类CP/CPPS的男性。对照组包括了13名健康男性。研究人员分别通过鲁米诺

慢性前列腺炎/慢性盆腔疼痛综合症(CP/CPPS)经常与阴茎勃起功能障碍(ED)相关。然而,ED发生的潜在病理生理学机制在患有CP/CPPS的患者中仍旧不清楚。

最近,有研究人员调查了超氧阴离子和总活性氧种类在IIIA类CP/CPPS男性患者的精液中的产生情况,并调查了其与ED的相关性。他们的前瞻性研究包括了33名患有IIIA类CP/CPPS的男性。对照组包括了13名健康男性。研究人员分别通过鲁米诺和荧光素依赖的化学发光(CL)方法分别对总的ROS和超氧阴离子的产生进行了评估。另外,ED通过IIEF-5调查问卷来进行评估。研究发现,与健康对照相比,CP/CPPS患者具有显著更高的总ROS和超氧阴离子水平(鲁米诺依赖的CL:2.9±0.5 相对发光单位(RLU) vs. 2.4±0.2 RLU, p<0.001;  荧光素依赖的CL:2.5±0.4 RLU vs. 2.3±0.2 RLU, p=0.02;)。另外,精液超氧阴离子和ROS水平与IIEF=5得分呈现负相关关系(分别为r=-0.556, r=-0.536; p<0.001)。

最后,研究人员指出,他们的结果表明了ZAI CP/CPPS患者中,超氧阴离子/ROS的过量产生是ED病因学上的一个重要的机制。

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    2019-03-19 habb
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    2018-09-06 jyzxjiangqin

    精液中的活性氧。

    0

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href='/topic/show?id=6f66121e89e' target=_blank style='color:#2F92EE;'>#MPO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12178, encryptionId=6f66121e89e, topicName=MPO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7b9016060451, createdName=风铃826, createdTime=Thu Aug 16 01:51:00 CST 2018, time=2018-08-16, status=1, ipAttribution=)]
    2018-08-28 jyzxjiangqin

    精液中的活性氧种类水平。

    0

  5. 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href='/topic/show?id=6f66121e89e' target=_blank style='color:#2F92EE;'>#MPO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12178, encryptionId=6f66121e89e, topicName=MPO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7b9016060451, createdName=风铃826, createdTime=Thu Aug 16 01:51:00 CST 2018, time=2018-08-16, status=1, ipAttribution=)]
    2018-08-16 dingxiaobo
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    2018-08-16 hb2008ye
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href='/topic/show?id=6f66121e89e' target=_blank style='color:#2F92EE;'>#MPO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12178, encryptionId=6f66121e89e, topicName=MPO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7b9016060451, createdName=风铃826, createdTime=Thu Aug 16 01:51:00 CST 2018, time=2018-08-16, status=1, ipAttribution=)]
    2018-08-16 徐岩
  8. 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href='/topic/show?id=6f66121e89e' target=_blank style='color:#2F92EE;'>#MPO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12178, encryptionId=6f66121e89e, topicName=MPO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7b9016060451, createdName=风铃826, createdTime=Thu Aug 16 01:51:00 CST 2018, time=2018-08-16, status=1, ipAttribution=)]
  9. 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  10. 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    2018-08-16 风铃826

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最近,有研究人员在一个代表性研究的泌尿道检查中,评估了客观的(拉长的)和主观的阴茎大小对勃起功能的影响。研究包括了689名年龄在35岁-70岁的男性。研究人员在多变量模型中利用逻辑回归和线性回归调查了IIEF-5调查问卷、身体检查(阴茎长度、前列腺体积、血压、身体质量指数-BMI)、代谢综合征(MS)、并发症、习惯(性交频率、身体活动、酒精和烟草使用情况)、教育水平、血糖、总睾丸素、雌二醇、PSA

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在动物模型中,短期睾丸素的抑制能够减少小梁平滑肌含量并且增加间质结缔组织的积累。然而,睾丸素的长期抑制的影响仍旧不清楚。最近,有研究人员在小鼠中评估了睾丸素长期抑制对阴茎结构和勃起功能的影响。研究发现,血清睾丸素水平、阴茎长度和周长、海绵体平滑肌含量和eNOS活性在激素阻断动物模型中均显著降低;上述影响的结果可以通过睾丸素十一酸睾丸素注入得到恢复。在小鼠中,勃起功能可以通过睾丸素替代物为期4周的给

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