Medicine:针灸治疗肥胖症瘦素抵抗

2021-10-14 MedSci原创 MedSci原创

肥胖是一种代谢障碍性疾病,由于长期能量摄入大于身体消耗,体内脂肪堆积过多,导致超重,肥胖是糖尿病、高血压、冠心病等慢性病的危险因素。

肥胖是一种代谢障碍性疾病,由于长期能量摄入大于身体消耗,体内脂肪堆积过多,导致超重肥胖是糖尿病、高血压、冠心病等慢性病的危险因素。近年来全球肥胖相关疾病的增加,使其防治成为21世纪范围内重大的公共卫生挑战。

瘦素的含量水平在肥胖患者体内较高,但未能较好发挥抑制食欲的作用,研究者提出肥胖患者可能存在瘦素抵抗(LR)。LR瘦素抑制食欲和减缓体重增加的能力降低,肥胖患者多见,瘦素的血清水平随着体重的减轻,即LR改善,而降低。

中医(TCM)针灸治疗被誉为绿色疗法,许多临床和实验研究表明,针灸对肥胖症有很好的治疗效果,但针灸减肥的机制迄今尚未明确报道。一些研究表明,针灸可提高瘦素水平。然而,目前还没有针刺治疗肥胖瘦素抵抗的系统评价,本研究首次使用荟萃分析探讨针刺对肥胖患者瘦素抵抗影响的随机对照试验。 

各大数据库进行检索通过使用主题词 “肥胖”、“瘦素抵抗”、“针灸”、“随机对照试验”、“对照临床试验”等搜索文献类型限定为RCT 试验。实验组患者以针刺为主要干预措施,包括手法针刺、电针、耳针和穴位注射。统计结果包括血清瘦素水平、BW、体重指数(BMI)、腰臀比(WHR)、有效率资料导入Endnote两位审稿人独立筛选了数据第三审稿人复审。使用 Review Managerversion5.3,创建流程图和 PRISMA 量表。Revman 5.3 和Stata 16 软件用于荟萃分析。连续变量的加权平均差 (WMD) 计算为 95% 置信区间 (CI)。Q检验和I 2检验用于评估数据的异质性。当异质性不显着(P ≥ .10 或 I 2  < 50%)时,采用固定效应模型分析合并效应,当异质性具有统计学意义(I 2 ≥50% 或P  < .10)时,采用固定效应模型分析合并效应。使用随机效应模型通过亚组分析探讨了异质性的原因。生成森林图以说明治疗效果的相应变化。对结果进行评估包括偏倚风险、异质性、间接性、不精确性和发表偏倚。

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研究表明, 经中医针灸治疗肥胖患者血清瘦素水平显着下降,可有效改善肥胖者瘦素抵抗状态。

 

综上,药物减肥虽具有一定的便捷优势,但西药刺激肠,长期服药会产生不良反应。针灸作为一种替代疗法治疗瘦素抵抗可减少体内脂肪合成,改善其代谢功能。

本研究可为针灸治疗肥胖症瘦素抵抗的相关研究提供依据。由于无法搜索所有数据库及未发表文献,本研究可能存在一些资料不完善的问题。

原文链接:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284727/?vToken=EHAvwWZfAAgwtaQ5lkKuFQ%3D%3D

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GetPortalCommentsPageByObjectIdResponse(id=1773998, encodeId=f6371e7399806, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Wed Mar 30 09:51:03 CST 2022, time=2022-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061215, encodeId=cb4610612151a, content=medicine 现如今沦为protocol的重灾区,这么下去,被剔除sci只是时间问题,一些没有意义的研究也能被接受,纯粹是见钱眼开的行为,没有meta分析的数据支撑,请williamhill asia 医学发表文章前考虑一下文章的质量。, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2022-03-14 jeanqiuqiu
  2. 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    2022-02-12 1478bd89m27暂无昵称

    谢谢分享

    0

  3. 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  4. 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GetPortalCommentsPageByObjectIdResponse(id=1773998, encodeId=f6371e7399806, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Wed Mar 30 09:51:03 CST 2022, time=2022-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061215, encodeId=cb4610612151a, content=medicine 现如今沦为protocol的重灾区,这么下去,被剔除sci只是时间问题,一些没有意义的研究也能被接受,纯粹是见钱眼开的行为,没有meta分析的数据支撑,请williamhill asia 医学发表文章前考虑一下文章的质量。, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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encodeId=22661611294d5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Oct 16 00:51:03 CST 2021, time=2021-10-16, status=1, ipAttribution=)]
    2021-11-21 ms9000000466496502

    这个杂志的也发??

    0

  5. 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GetPortalCommentsPageByObjectIdResponse(id=1773998, encodeId=f6371e7399806, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Wed Mar 30 09:51:03 CST 2022, time=2022-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061215, encodeId=cb4610612151a, content=medicine 现如今沦为protocol的重灾区,这么下去,被剔除sci只是时间问题,一些没有意义的研究也能被接受,纯粹是见钱眼开的行为,没有meta分析的数据支撑,请williamhill asia 医学发表文章前考虑一下文章的质量。, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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encodeId=22661611294d5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Oct 16 00:51:03 CST 2021, time=2021-10-16, status=1, ipAttribution=)]
    2022-03-30 kalseyzl
  6. 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GetPortalCommentsPageByObjectIdResponse(id=1773998, encodeId=f6371e7399806, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Wed Mar 30 09:51:03 CST 2022, time=2022-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061215, encodeId=cb4610612151a, content=medicine 现如今沦为protocol的重灾区,这么下去,被剔除sci只是时间问题,一些没有意义的研究也能被接受,纯粹是见钱眼开的行为,没有meta分析的数据支撑,请williamhill asia 医学发表文章前考虑一下文章的质量。, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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encodeId=22661611294d5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Oct 16 00:51:03 CST 2021, time=2021-10-16, status=1, ipAttribution=)]
    2021-10-17 CottonBlue

    medicine 现如今沦为protocol的重灾区,这么下去,被剔除sci只是时间问题,一些没有意义的研究也能被接受,纯粹是见钱眼开的行为,没有meta分析的数据支撑,请williamhill asia 医学发表文章前考虑一下文章的质量。

    0

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objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71253, encryptionId=5065e125368, topicName=瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Sat Oct 16 00:51:03 CST 2021, time=2021-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577843, encodeId=df8c15e784331, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Sat Oct 16 00:51:03 CST 2021, time=2021-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611294, encodeId=22661611294d5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Oct 16 00:51:03 CST 2021, time=2021-10-16, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1859194, encodeId=a4d11859194f9, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Mon Mar 14 07:51:03 CST 2022, time=2022-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1192655, encodeId=76861192655cb, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70ae5225349, createdName=1478bd89m27暂无昵称, createdTime=Sat Feb 12 12:32:06 CST 2022, time=2022-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055512, encodeId=700e205551290, content=<a href='/topic/show?id=3b2096294d7' target=_blank style='color:#2F92EE;'>#针灸治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96294, encryptionId=3b2096294d7, topicName=针灸治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce5632, createdName=jianjun66, createdTime=Sat Oct 23 05:51:03 CST 2021, time=2021-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1072446, encodeId=26af10e244613, content=这个杂志的也发??, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a3f5473270, createdName=ms9000000466496502, createdTime=Sun Nov 21 09:47:06 CST 2021, time=2021-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773998, encodeId=f6371e7399806, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Wed Mar 30 09:51:03 CST 2022, time=2022-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061215, encodeId=cb4610612151a, content=medicine 现如今沦为protocol的重灾区,这么下去,被剔除sci只是时间问题,一些没有意义的研究也能被接受,纯粹是见钱眼开的行为,没有meta分析的数据支撑,请williamhill asia 医学发表文章前考虑一下文章的质量。, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210430/93d5a69806694178992860f4bc5381db/691fec10e73e496d80c33ae33d2445ea.jpg, createdBy=68915449010, createdName=CottonBlue, createdTime=Sun Oct 17 13:25:37 CST 2021, time=2021-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269490, encodeId=60d31269490c4, content=<a href='/topic/show?id=f6818192258' target=_blank style='color:#2F92EE;'>#肥胖症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81922, encryptionId=f6818192258, topicName=肥胖症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c66088, createdName=gao_jian4217, createdTime=Sat Oct 16 00:51:03 CST 2021, time=2021-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366651, encodeId=ad26136665184, content=<a href='/topic/show?id=5065e125368' target=_blank style='color:#2F92EE;'>#瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71253, encryptionId=5065e125368, topicName=瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Sat Oct 16 00:51:03 CST 2021, time=2021-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577843, encodeId=df8c15e784331, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Sat Oct 16 00:51:03 CST 2021, time=2021-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611294, encodeId=22661611294d5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Oct 16 00:51:03 CST 2021, time=2021-10-16, status=1, ipAttribution=)]
    2021-10-16 sodoo
  9. [GetPortalCommentsPageByObjectIdResponse(id=1859194, encodeId=a4d11859194f9, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Mon Mar 14 07:51:03 CST 2022, time=2022-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1192655, encodeId=76861192655cb, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70ae5225349, createdName=1478bd89m27暂无昵称, createdTime=Sat Feb 12 12:32:06 CST 2022, time=2022-02-12, status=1, ipAttribution=), 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  10. 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GetPortalCommentsPageByObjectIdResponse(id=1773998, encodeId=f6371e7399806, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Wed Mar 30 09:51:03 CST 2022, time=2022-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061215, encodeId=cb4610612151a, content=medicine 现如今沦为protocol的重灾区,这么下去,被剔除sci只是时间问题,一些没有意义的研究也能被接受,纯粹是见钱眼开的行为,没有meta分析的数据支撑,请williamhill asia 医学发表文章前考虑一下文章的质量。, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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