JCEM:甲状腺功能减退症及其与成人睡眠呼吸暂停之间的关系

2019-07-16 xing.T MedSci原创

由此可见,在调整潜在的混杂变量后,甲状腺功能减退症与SA有关。

先前已经研究过甲状腺功能减退症与睡眠呼吸暂停(SA)之间的关联,但结果不一致,主要是由于小型人群研究。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在明确美国人群甲状腺功能减退症与SA之间是否存在正相关。

该研究为横断面研究,以美国国家健康与营养检查调查(NHANES)为基础,时间为2007-2008。研究人员纳入了符合标准的所有年满18岁的受试者。没有使用抗甲状腺药物治疗且甲状腺刺激素(TSH)>5.6mIU/L的受试者和不依赖TSH的甲状腺激素替代治疗参与者被归类为甲状腺功能减退症。未服用甲状腺激素替代治疗且TSH<0.34 mIU/L的受试者和不依赖TSH的抗甲状腺药物治疗的受试者被归类为甲亢。没有甲状腺激素替代治疗或抗甲状腺药物治疗且TSH为0.34-5.6mI/L的参与者被归类为甲状腺功能正常。SA的诊断是基于受试者的回答,当被问及他们是否被医生诊断为SA时。 研究人员进行多变量Logistic回归分析以确定甲状腺功能减退症与SA之间的关联。

该研究共纳入了5515名成人进行数据分析。甲状腺功能减退症和甲状腺功能亢进症的患病率分别为9.47%和1.19%。针对人口统计学指标、医疗保健准入、体重指数、社会经济因素、酒精使用、吸烟和其他合并症调整的多变量Logistic回归分析显示甲状腺功能减退症与SA之间存在显著相关性(OR=1.88,95%CI为1.24-2.84,P<0.01)。

由此可见,在调整潜在的混杂变量后,甲状腺功能减退症与SA有关。 

原始出处:

Subhanudh Thavaraputta,et al.Hypothyroidism and its Association with Sleep Apnea Among Adults in The United States: NHANES 2007-2008.J Clin Endocrinol Metab. 2019.https://doi.org/10.1210/jc.2019-01132

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    2020-02-23 achengzhao
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    2019-11-08 smallant2015
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