Cell Stem Cell:促进结肠癌生长的重要癌症干细胞群体

2015-06-18 佚名 生物谷

最近,来自劳森健康研究所的研究人员在结肠中发现一个新的干细胞群与结肠癌生长具有重要联系。近日,相关研究结果发表在国际学术期刊Cell Stem Cell。 结肠癌是加拿大癌症相关死亡的第二号杀手,据估计2015年将有25,100名加拿大人患上结肠癌,占所有新发癌症病例的13%。 在该项研究中,研究人员在结肠癌中发现了一群新的癌症干细胞,这群细胞具有寿命长以及放射性抵抗的特性。更



最近,来自劳森健康研究所的研究人员在结肠中发现一个新的干细胞群与结肠癌生长具有重要联系。近日,相关研究结果发表在国际学术期刊Cell Stem Cell
 
结肠癌是加拿大癌症相关死亡的第二号杀手,据估计2015年将有25,100名加拿大人患上结肠癌,占所有新发癌症病例的13%。
 
在该项研究中,研究人员在结肠癌中发现了一群新的癌症干细胞,这群细胞具有寿命长以及放射性抵抗的特性。更为重要的是,他们还发现这些干细胞能够形成结肠癌肿瘤进而维持肿瘤生长。组织干细胞是一群非常独特的细胞,对于正常组织的维持和再生具有非常重要的作用,它们同样具有寿命长的特性,但正是因为这一点也使得组织干细胞很容易变成癌症的起源。研究人员指出,鉴定癌症发生的细胞起源,特别是对结肠癌来说,对于理解癌症如何发生以及开发靶向治疗药物具有关键作用。
 
在该项研究中,研究人员发现结肠中存在不止一个干细胞池,他们提出,这一发现是非常具有挑战性的,同时也非常令人兴奋,这对于开发结肠癌靶向治疗药物非常重要,同时也证明在肿瘤发生和生长过程中可能不止一个干细胞群在发挥重要作用,提示williamhill asia 在癌症治疗过程中需要同时靶向多个干细胞池,抑制肿瘤生长。
 
在该项研究之前,科学家们一直认为只有一群癌症干细胞与结肠癌发生有关,并且这群细胞具有放射敏感性,这使得研究人员相信通过放射治疗可以有效抑制结肠癌的发展,但这项研究结果告诉williamhill asia ,事实可能并非如此。

原始出处:

Samuel Asfaha, Yoku Hayakawa, Ashlesha Muley,et al.Krt19+/Lgr5− Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine.Cell Stem  Cell.Volume 16, Issue 6, p627–638,June 4,2015.

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    2016-05-02 维他命
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    2016-02-07 xjy13
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10:56:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28373, encodeId=a178283e3b7, content=(⊙o⊙), beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 10:56:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332991, encodeId=b9fa1332991af, content=<a href='/topic/show?id=2ab5e13481f' target=_blank style='color:#2F92EE;'>#癌症干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71348, encryptionId=2ab5e13481f, topicName=癌症干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1d2500084, createdName=1249884fm87暂无昵称, createdTime=Sat Jun 20 04:55:00 CST 2015, time=2015-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481871, encodeId=c55114818e120, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Sat Jun 20 04:55:00 CST 2015, time=2015-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28069, encodeId=ef042806914, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu Jun 18 14:42:00 CST 2015, time=2015-06-18, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1959398, encodeId=aa451959398ad, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon May 02 03:55:00 CST 2016, time=2016-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794388, encodeId=fa631e9438830, content=<a href='/topic/show?id=82b416e79f5' target=_blank style='color:#2F92EE;'>#stem cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16779, encryptionId=82b416e79f5, topicName=stem cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sat Dec 05 12:55:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1716936, encodeId=73481e1693679, content=<a href='/topic/show?id=f8a98002eb1' target=_blank style='color:#2F92EE;'>#群体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80027, encryptionId=f8a98002eb1, topicName=群体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c0832353243, createdName=xjy13, createdTime=Sun Feb 07 11:55:00 CST 2016, time=2016-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869144, encodeId=5e3618691449d, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Fri Jul 17 03:55:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29206, encodeId=88832920607, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu Jun 25 23:01:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28372, encodeId=6b87283e207, content=。, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 10:56:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28373, encodeId=a178283e3b7, content=(⊙o⊙), beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 10:56:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332991, encodeId=b9fa1332991af, content=<a href='/topic/show?id=2ab5e13481f' target=_blank style='color:#2F92EE;'>#癌症干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71348, encryptionId=2ab5e13481f, topicName=癌症干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1d2500084, createdName=1249884fm87暂无昵称, createdTime=Sat Jun 20 04:55:00 CST 2015, time=2015-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481871, encodeId=c55114818e120, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Sat Jun 20 04:55:00 CST 2015, time=2015-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28069, encodeId=ef042806914, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu Jun 18 14:42:00 CST 2015, time=2015-06-18, status=1, ipAttribution=)]
    2015-06-25 huaxipanxing

    看看

    0

  6. 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10:56:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28373, encodeId=a178283e3b7, content=(⊙o⊙), beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 10:56:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332991, encodeId=b9fa1332991af, content=<a href='/topic/show?id=2ab5e13481f' target=_blank style='color:#2F92EE;'>#癌症干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71348, encryptionId=2ab5e13481f, topicName=癌症干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1d2500084, createdName=1249884fm87暂无昵称, createdTime=Sat Jun 20 04:55:00 CST 2015, time=2015-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481871, encodeId=c55114818e120, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Sat Jun 20 04:55:00 CST 2015, time=2015-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28069, encodeId=ef042806914, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu Jun 18 14:42:00 CST 2015, time=2015-06-18, status=1, ipAttribution=)]
    2015-06-21 18619c0a62m

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1959398, encodeId=aa451959398ad, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon May 02 03:55:00 CST 2016, time=2016-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794388, encodeId=fa631e9438830, content=<a href='/topic/show?id=82b416e79f5' target=_blank style='color:#2F92EE;'>#stem cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16779, encryptionId=82b416e79f5, topicName=stem cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, 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10:56:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28373, encodeId=a178283e3b7, content=(⊙o⊙), beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 10:56:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332991, encodeId=b9fa1332991af, content=<a href='/topic/show?id=2ab5e13481f' target=_blank style='color:#2F92EE;'>#癌症干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71348, encryptionId=2ab5e13481f, topicName=癌症干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1d2500084, createdName=1249884fm87暂无昵称, createdTime=Sat Jun 20 04:55:00 CST 2015, time=2015-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481871, encodeId=c55114818e120, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Sat Jun 20 04:55:00 CST 2015, time=2015-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28069, encodeId=ef042806914, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu Jun 18 14:42:00 CST 2015, time=2015-06-18, status=1, ipAttribution=)]
    2015-06-21 18619c0a62m

    (⊙o⊙)

    0

  8. 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    2015-06-18 summer474cn

    0

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