SCI REP:血铅水平与青少年心血管危险因素有何关系?

2017-08-23 xing.T MedSci原创

这些结果提供的流行病学证据表明,在青少年群体中,低水平血铅与低密度脂蛋白胆固醇之间存在密切的正相关性。

很少有关于环境铅暴露对青少年人群心血管危险因素影响的研究。近日,Scientific reports 杂志上发表了一篇研究文章,研究人员分析了11662例在1999年至2012年期间参与国家健康和营养调查(NHANES)研究的参与者数据。

研究人员分析了血铅水平与心血管危险因素(CVRF)之间的关系,并在校正了年龄、性别、种族、血清可替宁、体重指数(BMI)、体力活动和家庭收入后,采用多元线性回归估计了血铅水平与CVRF(例如,总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯、空腹血糖、糖化血红蛋白、空腹胰岛素、血压)之间相关性的回归系数(β)和95%可信区间(CI)。

研究人员发现青少年(12岁-19岁)血铅水平(系数=0.022,95%CI为0.003-0.041;P=0.022)与低密度脂蛋白胆固醇之间具有密切的正相关性。然而,在整体人群中,没有发现血铅水平与其他CVRFs之间具有相关性。在广义线性模型中,血铅水平最高的参与者相比于血铅水平最低的参与者表现出血清低密度脂蛋白胆固醇增加1.87%(95%CI为0.73%-3.02%)(趋势P=0.031)。

这些结果提供的流行病学证据表明,在青少年群体中,低水平血铅与低密度脂蛋白胆固醇之间存在密切的正相关性。

原始出处:

Cheng Xu,et al. Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-09701-4?error=server_error

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    2017-08-24 tanxingdoctor

    学习啦!谢谢分享

    0

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    2017-08-23 changjiu

    学习了.谢谢

    0

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