EBCAM:基于网络药理学的黄芪四君子汤治疗阿尔茨海默病机制研究

2021-10-21 Vivi MedSci原创

目前临床治疗阿尔茨海默病(AD)最常用药物是胆碱酯酶抑制剂，只能改善部分症状，需要寻找新的药物和治疗方法。黄芪四君子汤对AD有一定疗效，但具体治疗作用和机制尚未明确，该研究基于网络药理学进行探索。

阿尔茨海默病(Alzheimer 's disease, AD)是一种神经退行性疾病，伴有进行性记忆和认知能力下降。目前临床治疗AD最常用的药物是胆碱酯酶抑制剂多奈哌齐、利伐他明、加兰他明、安理辛等，它们只是通过增加乙酰胆碱(Ach)来改善AD的部分症状。寻找新的药物和治疗方法来预防AD至关重要。

黄芪四君子汤是常用的健气、补阳、祛湿的传统中药方剂，包括:黄芪、人参、白术、茯苓、甘草。黄芪作为方中主要成分，在许多疾病的治疗中起着非常有效的作用。现代药理学和临床应用表明，黄芪四君子汤对AD有一定疗效。黄芪四君子汤对AD的治疗作用尚未完全阐明，有必要确定其对AD的作用，进行进一步的系统研究。

近期在Evid Based Complement Alternat Med 发表的一项研究，通过在中药系统药理学数据库与分析平台(TCMSP)中检索黄芪四君子汤的活性成分和靶点，利用UniProt和GeneCard数据库检索与靶标对应的基因名称。利用Cytoscape构建了中草药-化合物-靶标网络和蛋白-蛋白相互作用(PPI)网络。利用基因本体论(GO)和京都基因与基因组百科全书(KEGG)对黄芪四君子汤的核心靶标进行分析。主要活性成分与乙酰胆碱酯酶(AChE)对接，并采用体外实验进行验证。

化合物-靶标网络主要包含132个化合物和255个对应靶标。主要成分有槲皮素、山奈酚、刺芒柄花素等，关键靶标包括AChE、PTGS2、PPARG、IL-1B、GSK3B等。分子对接结果表明，槲皮素和刺芒柄花素是黄芪四君子汤中最活跃的2个化合物，其中刺芒柄花素对乙酰胆碱酯酶的抑制作用最强。体外实验表明刺芒柄花素具有良好的神经保护作用，可改善神经细胞的氧化损伤。

该研究通过网络药理学方法、分子对接技术和体外实验，明确了黄芪四君子汤治疗AD的多成分、多靶点机制，为开发黄芪四君子汤作为AD的创新性替代疗法提供了理论依据。

文献来源：

Zhang W, Lv M, Shi Y, Mu Y, Yao Z, Yang Z. Network Pharmacology-Based Study of the Underlying Mechanisms of Huangqi Sijunzi Decoction for Alzheimer's Disease. Evid Based Complement Alternat Med. 2021 Oct 5;2021:6480381. doi: 10.1155/2021/6480381.

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2023-09-23 侠胆医心来自上海

基于#网络药理学#的#黄芪##四君子汤#治疗#阿尔茨海默病#机制研究

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2022-05-18 whmdzju

#CAM#

71 0
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2022-04-24 12498da4m32(暂无昵称)

#阿尔茨海#

82 0
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2022-07-06 ms1948154235210413

#阿尔茨#

60 0
[GetPortalCommentsPageByObjectIdResponse(id=2159219, encodeId=81a821592195b, content=基于<a href='/topic/show?id=8d82e952353' target=_blank style='color:#2F92EE;'>#网络药理学#</a>的<a href='/topic/show?id=9c2d1031961f' target=_blank style='color:#2F92EE;'>#黄芪#</a><a href='/topic/show?id=c24a106655c4' target=_blank style='color:#2F92EE;'>#四君子汤#</a>治疗<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>机制研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79523, encryptionId=8d82e952353, topicName=网络药理学), TopicDto(id=103196, encryptionId=9c2d1031961f, topicName=黄芪), TopicDto(id=106655, encryptionId=c24a106655c4, topicName=四君子汤), TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Sat Sep 23 00:07:19 CST 2023, time=2023-09-23, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1675377, encodeId=977e16e53772d, content=<a href='/topic/show?id=cb8a400091' target=_blank style='color:#2F92EE;'>#CAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4000, encryptionId=cb8a400091, topicName=CAM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16ac27217804, createdName=whmdzju, createdTime=Wed May 18 01:59:40 CST 2022, time=2022-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818145, encodeId=15a918181454e, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sun Apr 24 14:59:40 CST 2022, time=2022-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1817122, encodeId=47c8181e122ca, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Wed Jul 06 07:59:40 CST 2022, time=2022-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056220, encodeId=cbe02056220d4, content=<a href='/topic/show?id=616b611e9bc' target=_blank style='color:#2F92EE;'>#机制研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61179, encryptionId=616b611e9bc, topicName=机制研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Tue Mar 22 20:59:40 CST 2022, time=2022-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470499, encodeId=547914e04991e, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Sat Oct 23 11:59:40 CST 2021, time=2021-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516191, encodeId=f192151619190, content=<a href='/topic/show?id=7e868e9126b' target=_blank style='color:#2F92EE;'>#药理学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87912, encryptionId=7e868e9126b, topicName=药理学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sat Oct 23 11:59:40 CST 2021, time=2021-10-23, status=1, ipAttribution=)]
2022-03-22 爆笑小医

#机制研究#

72 0
[GetPortalCommentsPageByObjectIdResponse(id=2159219, encodeId=81a821592195b, content=基于<a href='/topic/show?id=8d82e952353' target=_blank style='color:#2F92EE;'>#网络药理学#</a>的<a href='/topic/show?id=9c2d1031961f' target=_blank style='color:#2F92EE;'>#黄芪#</a><a href='/topic/show?id=c24a106655c4' target=_blank style='color:#2F92EE;'>#四君子汤#</a>治疗<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>机制研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79523, encryptionId=8d82e952353, topicName=网络药理学), TopicDto(id=103196, encryptionId=9c2d1031961f, topicName=黄芪), TopicDto(id=106655, encryptionId=c24a106655c4, topicName=四君子汤), TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Sat Sep 23 00:07:19 CST 2023, time=2023-09-23, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1675377, encodeId=977e16e53772d, content=<a href='/topic/show?id=cb8a400091' target=_blank style='color:#2F92EE;'>#CAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4000, encryptionId=cb8a400091, topicName=CAM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16ac27217804, createdName=whmdzju, createdTime=Wed May 18 01:59:40 CST 2022, time=2022-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818145, encodeId=15a918181454e, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sun Apr 24 14:59:40 CST 2022, time=2022-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1817122, encodeId=47c8181e122ca, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Wed Jul 06 07:59:40 CST 2022, time=2022-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056220, encodeId=cbe02056220d4, content=<a href='/topic/show?id=616b611e9bc' target=_blank style='color:#2F92EE;'>#机制研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61179, encryptionId=616b611e9bc, topicName=机制研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Tue Mar 22 20:59:40 CST 2022, time=2022-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470499, encodeId=547914e04991e, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Sat Oct 23 11:59:40 CST 2021, time=2021-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516191, encodeId=f192151619190, content=<a href='/topic/show?id=7e868e9126b' target=_blank style='color:#2F92EE;'>#药理学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87912, encryptionId=7e868e9126b, topicName=药理学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sat Oct 23 11:59:40 CST 2021, time=2021-10-23, status=1, ipAttribution=)]
2021-10-23 yhj-time

#阿尔茨海默#

71 0
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2021-10-23 docwu2019

#药理学#

63 0

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