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Brit J Cancer：患有前列腺癌男性手术前体重的减少影响肿瘤性状和循环生物标记

2017-09-20 AlexYang MedSci原创

前列腺癌体重肥胖
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之前的研究表明，肥胖与恶性前列腺癌相关。最近，有研究人员为了探究是否体重减少可以影响肿瘤生物学和其他结果，进行了超重和肥胖的前列腺癌患者手术前试验。研究为单盲、双臂随机对照试验，从而探究术前体重减轻干预（WLI）对患者结果的影响。每周大约1千克的体重减少是是通过限制卡路里摄入和增加身体活动（PA）来实现的。研究所包括的40名患有临床上确定的前列腺癌超重/肥胖男性患者被随机分配到ILI术前组和对照组

之前的研究表明，肥胖与恶性前列腺癌相关。最近，有研究人员为了探究是否体重减少可以影响肿瘤生物学和其他结果，进行了超重和肥胖的前列腺癌患者手术前试验。研究为单盲、双臂随机对照试验，从而探究术前体重减轻干预（WLI）对患者结果的影响。每周大约1千克的体重减少是是通过限制卡路里摄入和增加身体活动（PA）来实现的。研究所包括的40名患有临床上确定的前列腺癌超重/肥胖男性患者被随机分配到ILI术前组和对照组。另外，研究人员还在肿瘤和良性前列腺组织中评估了体重的变化、身体成分、生活品质、循环生物标记、基因表达和免疫组化标记等参数。

研究时间平均为50天。WLI组和对照组相关变化平均得分分别为：体重：4.7 (3.1)kg vs 2.2 (4.4)kg (P=0.0508)； 卡路里摄入： 500 (636) vs 159 (600)kcal per day (P=0.0034)；身体活动：+0.9 (3.1) vs +1.7 (4.6) MET-hours per day (NS)；生命力：+5.3 (7.l4) vs 1.8 (8.1) (P=0.0491)；睾丸素：+55.1 (86.0) vs 48.3 (203.7)ng/dl(P=0.0418)；性激素结合球蛋白：+14.0 (14.6) vs +1.8 (7.6)nmol/l (P=0.0023)；以及瘦素：2.16 (2.6) vs 0.03 (3.75) (P=0.0355)。另外，Ki67在WLI组中要比对照组中含量显著更高；中值（四分位差）：5.0 (2.5，10.0) vs 0.0 (0.0，2.5) (P=0.0061)，并且一些基因在WLI组中表达上调，比如CTSL， GSK3B， MED12和LAMC2。

最后，研究人员指出，有意识的体重减少表现出了对循环生物标记、肿瘤基因表达和增殖标记的混合影响。另外，在男性前列腺癌患者中推荐体重减少尤其是快速体重减少之前，还需要更多的研究。

原始出处：

Wendy Demark-Wahnefried， Soroush Rais-Bahrami， Renee A Desmond et al. Presurgical weight loss affects tumour traits and circulating biomarkers in men with prostate cancer. Brit J Cancer. 07 Sep 2017.

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    2017-09-24 沙漠浪人

    前列腺疾病需要高度警惕

    0

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    2017-09-22 12498fa0m11暂无昵称

    #生物标记#

    0

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    2017-09-21 有备才能无患

    之前的研究表明.肥胖与恶性前列腺癌相关.最近.有研究人员为了探究是否体重减少可以影响肿瘤生物学和其他结果.进行了超重和肥胖的前列腺癌患者手术前试验

    0

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    2017-09-21 明月清辉

    谢谢分享.学习了

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    2017-09-21 忠诚向上

    好好努力学习

    0

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    2017-09-20 135****7952平儿

    学了........

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    2017-09-20 1e1b8538m79(暂无匿称)

    不错的文章不错的文章

    0

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