Crit Care Med:血管扩张剂治疗与非阻塞性肠系膜缺血患者死亡率

2020-02-15 xing.T MedSci原创

由此可见,采用罂粟碱和/或前列腺素E1进行血管扩张剂治疗与非阻塞性肠系膜缺血患者院内死亡率和腹部手术率降低相关。

先前的研究表明,血管扩张剂治疗可能对非阻塞性肠系膜缺血患者有益。但是,缺乏支持这种争论的有力证据。近日,危重病医学领域权威杂志Critical Care Medicine上发表了一篇研究文章,研究人员旨在检验以下假设:血管扩张剂治疗可能对非阻塞性肠系膜缺血患者有效。

这项回顾性队列研究,以日本诊断程序组合住院数据库为基础。在从2010年7月到2018年3月期间,共有1837例非阻塞性肠系膜缺血患者。

研究人员使用一到四个倾向评分匹配比较了接受血管扩张剂治疗的患者(血管扩张剂组;n=161)和未接受血管扩张剂治疗的患者(对照组;n=1676)。血管扩张药的治疗定义为入院后2天内通过静脉和/或动脉途径给予罂粟碱和/或前列腺素E1。研究人员仅分析了入院后2天内未接受腹部手术的患者。该研究的主要结局为入院后超过等于3天的院内死亡率和腹部手术。倾向评分匹配后,血管扩张剂组的院内死亡率显著降低(风险差异为–11.6%;p=0.005)。血管扩张剂组在入院后超过或等于3天接受腹部手术的患者比例也显著降低(风险差异为–10.2%;p=0.002)。

由此可见,采用罂粟碱和/或前列腺素E1进行血管扩张剂治疗与非阻塞性肠系膜缺血患者院内死亡率和腹部手术率降低相关。

原始出处:

Takiguchi.et al.Vasodilator Therapy and Mortality in Nonocclusive Mesenteric Ischemia A Nationwide Observational Study.critical care medicine.2020.https://journals.lww.com/ccmjournal/Abstract/onlinefirst/Vasodilator_Therapy_and_Mortality_in_Nonocclusive.95734.aspx

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    2020-08-13 lsj637
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    2020-03-01 tomyang96
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    2020-02-17 zzc2216
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