Diabetologia:祸不单行!部分子宫内膜异位症患者患2型糖尿病的风险升高

2021-01-09 Nebula MedSci原创

子宫内膜异位症是一种慢性、炎症性、雌激素依赖性疾病,其特征是在子宫外(主要是在腹膜腔内)出现子宫内膜样组织。约10%的育龄女性深受其影响,可导致痛经和不孕等症状。本研究旨在是调查腹腔镜确诊的子宫内膜异

子宫内膜异位症是一种慢性、炎症性、雌激素依赖性疾病,其特征是在子宫外(主要是在腹膜腔内)出现子宫内膜样组织。约10%的育龄女性深受其影响,可导致痛经和不孕等症状。本研究旨在是调查腹腔镜确诊的子宫内膜异位症与2型糖尿病风险之间的关系。

采用来自护士健康研究II(Nurses' Health Study II)的数据,这是一项女性护士的前瞻性队列,随访时间超过25年(N=112,037)。研究人员采用COX比例风险模型来估计风险比(HR)和95%置信区间(CI)。此外,研究人员还调查了年龄(<50岁或≥50岁)、体重指数(BMI)(<30或≥30 kg/m)、不孕史、绝经状况和妊娠期糖尿病病史(仅限于产妇)与子宫内膜异位症和2型糖尿病之间的相关性。

多变量混杂因素调整模型或考虑潜在中介因素的模型提示,在总人群中,未发现腹腔镜确诊的子宫内膜异位症与2型糖尿病风险之间存在关联(HR[95% CI]分别是1.06[0.98-1.13]和0.94[0.87-1.00])。然而,研究人员观察到,BMI组、不孕症病史和妊娠期糖尿病病史与子宫内膜异位症和2型糖尿病的相关性略有不同。在非肥胖女性、无不孕症女性和无妊娠期糖尿病病史的女性中,子宫内膜异位症与2型糖尿病的风险升高相关(HR[95% CI]分别是1.17[1.02-1.35]、1.14[1.04-1.25]、1.11[1.01-1.22])。

总体而言,子宫内膜异位症患者罹患2型糖尿病的风险没有增加。然而,在2型糖尿病风险本身较低的个体中(即非肥胖女性和无不孕或妊娠期糖尿病病史的女性),子宫内膜异位症与罹患2型糖尿病的风险略增高有关

原始出处:

Farland, L.V., Degnan, W.J., Harris, H.R. et al. A prospective study of endometriosis and risk of type 2 diabetes. Diabetologia (2021). https://doi.org/10.1007/s00125-020-05347-6

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    2021-01-10 zb1235672
  6. [GetPortalCommentsPageByObjectIdResponse(id=1708617, encodeId=ccf71e0861771, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Wed Aug 11 17:09:50 CST 2021, time=2021-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761567, encodeId=93ea1e6156781, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Wed Feb 24 06:09:50 CST 2021, time=2021-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1665678, encodeId=9fb116656e8d5, content=<a href='/topic/show?id=685445152f6' target=_blank style='color:#2F92EE;'>#子宫内膜异位#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45152, encryptionId=685445152f6, topicName=子宫内膜异位)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4de125981980, createdName=12498f17m74暂无昵称, createdTime=Sat Mar 13 23:09:50 CST 2021, time=2021-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639694, encodeId=08f5163969453, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sat Nov 13 14:09:50 CST 2021, time=2021-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915248, encodeId=bb0b915248ab, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sun Jan 10 14:51:47 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043455, encodeId=53e21043455cc, content=谢谢MedSci提供最新的威廉亚洲官网 , beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jan 10 00:09:50 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915091, encodeId=7f6991509192, content=收获很大, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210109/ef1ecf0b041d4ff3865842a710bb058a/a3f36bdb33ca42909f7ec16832eb98d7.jpg, createdBy=eb193979861, createdName=139a2447m67暂无昵称, createdTime=Sat Jan 09 22:27:34 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915041, encodeId=9e2c91504198, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Jan 09 21:59:46 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=914998, encodeId=59589149985f, content=<a href='/topic/show?id=49e345154a9' target=_blank style='color:#2F92EE;'>#子宫内膜异位症#</a>&<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45154, encryptionId=49e345154a9, topicName=子宫内膜异位症), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 09 21:16:59 CST 2021, time=2021-01-09, status=1, ipAttribution=)]
    2021-01-10 misszhang

    谢谢MedSci提供最新的威廉亚洲官网

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1708617, encodeId=ccf71e0861771, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Wed Aug 11 17:09:50 CST 2021, time=2021-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761567, encodeId=93ea1e6156781, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Wed Feb 24 06:09:50 CST 2021, time=2021-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1665678, encodeId=9fb116656e8d5, content=<a href='/topic/show?id=685445152f6' target=_blank style='color:#2F92EE;'>#子宫内膜异位#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45152, encryptionId=685445152f6, topicName=子宫内膜异位)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4de125981980, createdName=12498f17m74暂无昵称, createdTime=Sat Mar 13 23:09:50 CST 2021, time=2021-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639694, encodeId=08f5163969453, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sat Nov 13 14:09:50 CST 2021, time=2021-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915248, encodeId=bb0b915248ab, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sun Jan 10 14:51:47 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043455, encodeId=53e21043455cc, content=谢谢MedSci提供最新的威廉亚洲官网 , beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jan 10 00:09:50 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915091, encodeId=7f6991509192, content=收获很大, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210109/ef1ecf0b041d4ff3865842a710bb058a/a3f36bdb33ca42909f7ec16832eb98d7.jpg, createdBy=eb193979861, createdName=139a2447m67暂无昵称, createdTime=Sat Jan 09 22:27:34 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915041, encodeId=9e2c91504198, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Jan 09 21:59:46 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=914998, encodeId=59589149985f, content=<a href='/topic/show?id=49e345154a9' target=_blank style='color:#2F92EE;'>#子宫内膜异位症#</a>&<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45154, encryptionId=49e345154a9, topicName=子宫内膜异位症), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 09 21:16:59 CST 2021, time=2021-01-09, status=1, ipAttribution=)]
    2021-01-09 139a2447m67暂无昵称

    收获很大

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1708617, encodeId=ccf71e0861771, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Wed Aug 11 17:09:50 CST 2021, time=2021-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761567, encodeId=93ea1e6156781, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Wed Feb 24 06:09:50 CST 2021, time=2021-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1665678, encodeId=9fb116656e8d5, content=<a href='/topic/show?id=685445152f6' target=_blank style='color:#2F92EE;'>#子宫内膜异位#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45152, encryptionId=685445152f6, topicName=子宫内膜异位)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4de125981980, createdName=12498f17m74暂无昵称, createdTime=Sat Mar 13 23:09:50 CST 2021, time=2021-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639694, encodeId=08f5163969453, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sat Nov 13 14:09:50 CST 2021, time=2021-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915248, encodeId=bb0b915248ab, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sun Jan 10 14:51:47 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043455, encodeId=53e21043455cc, content=谢谢MedSci提供最新的威廉亚洲官网 , beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jan 10 00:09:50 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915091, encodeId=7f6991509192, content=收获很大, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210109/ef1ecf0b041d4ff3865842a710bb058a/a3f36bdb33ca42909f7ec16832eb98d7.jpg, createdBy=eb193979861, createdName=139a2447m67暂无昵称, createdTime=Sat Jan 09 22:27:34 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915041, encodeId=9e2c91504198, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Jan 09 21:59:46 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=914998, encodeId=59589149985f, content=<a href='/topic/show?id=49e345154a9' target=_blank style='color:#2F92EE;'>#子宫内膜异位症#</a>&<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45154, encryptionId=49e345154a9, topicName=子宫内膜异位症), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 09 21:16:59 CST 2021, time=2021-01-09, status=1, ipAttribution=)]
    2021-01-09 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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脐部子宫内膜异位症1 例

患者女, 36 岁,脐部结节伴周期性疼痛2 年。2 年前患者因子宫内膜异位症于当地医院行腹腔镜手 术,术后半年脐部手术切口末端出现米粒大小丘疹 并缓慢长大,丘疹触痛,疼痛与月经周期一致。皮肤 科情况:

这例37岁女性两度被诊断“肠癌”,但找不到肿瘤细胞!结局却峰回路转...

37岁青年女性病情迁延2年,腹痛、包块、便血、肠腔高度狭窄、肿瘤标志物升高……两度入院均考虑“肠癌”,然而两次肠镜活检都未及肿瘤细胞,最终真相揭晓,让她又“喜”,又“惊”!

J Sex Med:子宫内膜异位症引起的慢性盆腔疼痛女性的性满意度和性高潮的频率研究

性交困难是慢性妇科盆腔疼痛症子宫内膜异位症的主要症状之一,可能会干扰达到性高潮的可能性,然而对于性交困难的女性来说,关于不同性活动中性高潮率的数据仍旧缺乏。

子宫内膜异位症合并AUB-O诊疗分享

雷某,女,27岁初诊时间:2019年11月以“月经不规律伴痛经3年,发现盆腔包块3月余”主诉入院。

J Ovarian Res:IVF-ET前进行DNG治疗并不能改善子宫内膜异位症不孕妇女的临床疗效

子宫内膜异位症是导致女性不孕症最难治疗的原因。在体外受精和胚胎移植(IVF-ET)前治疗子宫内膜异位症是改善子宫内膜异位症不孕妇女IVF-ET结果的重要策略。据报道,在IVF-ET前使用促性腺激素释放

Cell rep:导致痛经和不孕的子宫内膜异位症的治疗靶标被发现

子宫内膜异位症是指有活性的内膜细胞种植在子宫内膜以外的位置而形成的一种女性常见妇科疾病,具体病因尚不完全清楚,最常见的症状是痛经,子宫内膜异位症患者中,不孕率高达40%~50%。