BioRxiv:早起的女人,患乳腺癌风险更低?

2018-11-11 佚名 中国生物技术网

近日,一项大型研究结果显示:早起的女性可能会降低患乳腺癌的风险。

近日,一项大型研究结果显示:早起的女性可能会降低患乳腺癌的风险。

近年来,睡眠和昼夜节律引起公众的广泛关注。因为它在控制着williamhill asia 每个人,所有人都无法逃避其摆布。

然而,尽管睡眠的影响无处不在,但是它对于williamhill asia 来说仍然充满了神秘色彩。很明显,睡眠对健康至关重要,但是研究人员仍未能确定其在疾病和健康方面的确切作用。

关于睡眠和昼夜节律最难回答的问题就是这些因素是如何影响导致疾病的,williamhill asia 是否能够通过改变睡眠的方式来降低健康风险。

最近,科学家们设计了一项研究来探究睡眠对乳腺癌风险的影响。该研究由英国布里斯托尔大学MRC综合流行病学研究室和英国癌症研究所综合癌症流行病学项目的研究员Rebecca Richmond博士领导。

睡眠和乳腺癌

Richmond博士团队从英国生物库项目中获取数据,该项目是一项长期研究,旨在解答有关疾病遗传和环境原因的问题。除此之外,他们还获取了国际乳腺癌协会联盟(BCAC)从乳腺癌全基因组关联研究中获得的数据。最终,他们总共使用了超过385000名女性的数据。

Richmond博士:“williamhill asia 使用与人们对早晚的偏好、睡眠持续时间和失眠相关的遗传变异,研究这些睡眠特征是否对乳腺癌的风险产生因果关系。”这项研究发表在预印本《bioRxiv》上。

为了发现睡眠模式和乳腺癌风险的趋势,该团队利用孟德尔随机化的方法。在分析中,研究人员使用已知功能基因的测量变异来评估其对疾病结果的影响。在这种情况下,他们研究了影响睡眠特征的基因变异。

这种方法对于减少潜在干扰变量来说非常有效。Richmond博士解释说:“这项研究中应用的孟德尔随机化方法对于确定疾病的因果风险因素特别有用,因为与睡眠特征相关的遗传变异不太可能受到任何外部或环境因素的影响,也不会受到癌症发展的影响。因此,可以用来确定因果关系。“

你要做个“云雀”还是夜猫子?

研究人员关注与特定睡眠因素相关的基因,比如偏好早晨或晚上、睡眠持续时间和失眠等。

通过对BCAC数据的分析,研究人员发现偏好早晨的女性(云雀)比偏好晚上的女性(夜猫子)患乳腺癌的风险低40%。

此外,研究结果还表明,睡眠时长超过推荐的7-8小时/晚的女性患乳腺癌风险更高,每额外增加一小时,风险增加20%。

该团队指出,对英国生物库数据的分析也得到类似的结果。早起的人比夜猫子患乳腺癌风险低48%。然而,这些数据揭示睡眠持续时间与乳腺癌之间相互作用的证据较少。

当然,对这种性质的研究可能会提出与其答案一样多的问题。因此,研究人员希望能够继续深入这一研究。

Richmond 博士说:“williamhill asia 希望进一步研究这些结果的机制,因为所得到的估计是基于有关早晨或晚上偏好的问题,而不是人们白天起得早还是晚。”

她继续说,“换句话说,改变你的习惯可能不会改变你患乳腺癌的风险,它可能比这更复杂。” 尽管在理解改变睡眠模式是否可以降低乳腺癌风险之前,还需要做更多的研究,但是这项研究的发现为睡眠与健康之间的关系提供了新的见解。

原始出处:Rebecca C Richmond, Emma L Anderson, Hassan S Dashti, et al. Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study. BioRxiv. November 5, 2018.

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    2019-02-25 sunylz
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    2019-06-05 sjq027
  4. 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createdBy=abd01695121, createdName=吴教授, createdTime=Mon Nov 12 11:39:14 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352371, encodeId=91783523e18c, content=有利于健康管理, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aab62481567, createdName=1245c785m69暂无昵称, createdTime=Mon Nov 12 11:34:11 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352370, encodeId=f5c93523e09a, content=哦很有帮助谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Mon Nov 12 11:08:42 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352360, encodeId=bb6235236047, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Mon Nov 12 09:05:40 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352345, encodeId=12db352345a7, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Nov 12 08:25:06 CST 2018, time=2018-11-12, status=1, ipAttribution=)]
    2018-11-13 orangesking

    看咯

    0

  5. 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createdBy=abd01695121, createdName=吴教授, createdTime=Mon Nov 12 11:39:14 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352371, encodeId=91783523e18c, content=有利于健康管理, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aab62481567, createdName=1245c785m69暂无昵称, createdTime=Mon Nov 12 11:34:11 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352370, encodeId=f5c93523e09a, content=哦很有帮助谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Mon Nov 12 11:08:42 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352360, encodeId=bb6235236047, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Mon Nov 12 09:05:40 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352345, encodeId=12db352345a7, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Nov 12 08:25:06 CST 2018, time=2018-11-12, status=1, ipAttribution=)]
    2018-11-13 lou.minghong

    中医早就指出了

    0

  6. 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createdBy=abd01695121, createdName=吴教授, createdTime=Mon Nov 12 11:39:14 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352371, encodeId=91783523e18c, content=有利于健康管理, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aab62481567, createdName=1245c785m69暂无昵称, createdTime=Mon Nov 12 11:34:11 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352370, encodeId=f5c93523e09a, content=哦很有帮助谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Mon Nov 12 11:08:42 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352360, encodeId=bb6235236047, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Mon Nov 12 09:05:40 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352345, encodeId=12db352345a7, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Nov 12 08:25:06 CST 2018, time=2018-11-12, status=1, ipAttribution=)]
    2018-11-12 吴教授

    谢谢分享,学习了

    0

  7. 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createdBy=abd01695121, createdName=吴教授, createdTime=Mon Nov 12 11:39:14 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352371, encodeId=91783523e18c, content=有利于健康管理, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aab62481567, createdName=1245c785m69暂无昵称, createdTime=Mon Nov 12 11:34:11 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352370, encodeId=f5c93523e09a, content=哦很有帮助谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Mon Nov 12 11:08:42 CST 2018, 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createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Nov 12 08:25:06 CST 2018, time=2018-11-12, status=1, ipAttribution=)]
    2018-11-12 1245c785m69暂无昵称

    有利于健康管理

    0

  8. 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time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352360, encodeId=bb6235236047, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Mon Nov 12 09:05:40 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352345, encodeId=12db352345a7, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Nov 12 08:25:06 CST 2018, time=2018-11-12, status=1, ipAttribution=)]
    2018-11-12 flysky120

    哦很有帮助谢谢

    0

  9. 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time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352360, encodeId=bb6235236047, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Mon Nov 12 09:05:40 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352345, encodeId=12db352345a7, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Nov 12 08:25:06 CST 2018, time=2018-11-12, status=1, ipAttribution=)]
    2018-11-12 kafei

    了解一下谢谢

    0

  10. 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createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Nov 12 08:25:06 CST 2018, time=2018-11-12, status=1, ipAttribution=)]
    2018-11-12 龙胆草

    学习谢谢分享

    0

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