GUT:累计粪便血红蛋白浓度对于结直肠肿瘤的预测作用

2019-08-28 佚名 MedSci原创

近年来,随着消费水平提升和人口老龄化,中国糖尿病患者数量大幅攀升。全国糖尿病检出率是多少,其与肥胖的相关性有多大,在性别、地域、年龄、季节分布上有何特点?8月28日,新华社中国经济信息社与美年大健康产业控股股份有限公司联合发布了“健康中国·体检大数据糖尿病地图”(简称“地图”),北京大学医学部美年公众健康研究院为学术支持单位。经分析全国447个美年大健康体检中心从2018年4月1日到2019年3月

近日研究人员考察了粪便血红蛋白(f-Hb)浓度对粪便免疫化学试验(FIT)阴性人群(小于20μg Hb/g 粪便),晚期结直肠肿瘤风险的预测作用。


研究在意大利开展,参与者年龄为50-69岁,每2年接受一次检查。考察在连续2次初次FIT检查阴性人群中,后续2FIT检查过程中,FIT阳性,大肠癌(CRC)或进展期腺瘤检出率(DR),评估f-Hb对晚期肿瘤预测的敏感性。


研究发现,初次2次检查中未检出f-Hb人群,后续2次检查FIT阳性风险为7.8%,而对于累积f-Hb浓度超过20μg/g粪便人群的FIT阳性风险为48.4%。相应的,累积DR风险:晚期腺瘤(AN)为1.4%25.5%CRC风险为0.17%4.5%


研究发现,累积粪便血红蛋白浓度对预测患者结直肠病变有重要作用,对于累积粪便血红蛋白浓度超过20μg的患者建议进行肠镜检查。


原始出处:


Carlo Senore et al. Faecal haemoglobin concentration among subjects with negative FIT results is associated with the detection rate of neoplasia at subsequent rounds a prospective study in the context of population based screening programmes in Italy.Gut. August 2019.


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    2019-08-30 huangdf
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    2019-08-30 Homburg
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