Oncotarget:手术切除有利于胰腺神经内分泌肿瘤患者生存!

2017-08-03 Emma MedSci原创

pNENs,pancreatic neuroendocrineneoplasm,即胰腺神经内分泌肿瘤,依据激素的分泌状态和患者的临床表现可分为功能性pNENs和无功能性pNENs。多为散发,发病高峰为40-69岁,男女发病率无明显差别。

pNENs,pancreatic neuroendocrineneoplasm,即胰腺神经内分泌肿瘤,依据激素的分泌状态和患者的临床表现可分为功能性pNENs和无功能性pNENs。多为散发,发病高峰为40-69岁,男女发病率无明显差别。临床表现多样,诊疗措施较复杂且周期较长,治疗一般建议在多学科协作模式下进行,并贯穿患者诊治的全部过程,主要根据患者的基础健康状况、激素分泌相关临床症状、肿瘤分期等信息,以循证医学为基础,个体化地应用多学科及多种治疗手段,以获得最佳的治疗效果。pNENs和胰腺癌都发生在胰腺,但这两种疾病的表现、治疗方法、治疗结果差别非常大。胰腺癌恶性程度极高,而pNENs则是为数不多的有希望治愈的胰腺肿瘤之一,所以罹患pNENs的患者一定不要放弃治疗!

研究人员根据原发性肿瘤是否局部治疗(手术切除),研究pNENs患者的生存情况。结果显示,局部治疗有利于PNETLM患者的癌症特异性生存和整体生存。该研究结果对患者的诊断和治疗方案制定具有积极作用。

根据SEER数据库确定了2010年至2014年期间诊断的患者,共191例肝转移胰腺神经内分泌肿瘤(PNETLM),分析他们的癌症特异性生存和总体存活率。其中有47例(24.6%)患者接受了手术切除,144例(75.4%)患者没有进行手术切除。从数据来看,N1期患者的治疗中更多的采用手术切除术,手术切除原发性肿瘤与癌症特异性生存(p=0.028)和总体生存率(p=0.025)有关,而未接受手术、未婚以及N1期是与生存不佳相关的因素。

原始出处:
Lianyuan T, et al. Surgical resection of primary tumor improves survival of pancreatic neuroendocrine tumor with liver metastases. Oncotarget. 2017 Jul 24. doi: 10.18632/oncotarget.19523.

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    2018-02-03 仁医06
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    2018-02-28 gwc392
  4. 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createdBy=763a37536718, createdName=1249898am27暂无昵称, createdTime=Sun Aug 20 07:42:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682337, encodeId=d238168233ebf, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Wed Feb 28 22:42:00 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1932586, encodeId=eebe1932586b2, content=<a href='/topic/show?id=5cd95305803' target=_blank style='color:#2F92EE;'>#患者生存#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, 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content=pNENs和胰腺癌都发生在胰腺,但这两种疾病的表现、治疗方法、治疗结果差别非常大。胰腺癌恶性程度极高,而pNENs则是为数不多的有希望治愈的胰腺肿瘤之一,所以罹患pNENs的患者一定不要放弃治疗!, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Aug 05 12:19:47 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230356, encodeId=a27a23035636, content=依据激素的分泌状态和患者的临床表现可分为功能性pNENs和无功能性pNENs。, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Aug 05 12:19:09 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230355, encodeId=dfdc230355ec, content=pNENs,pancreaticneuroendocrineneoplasm,即胰腺神经内分泌肿瘤, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Aug 05 12:18:49 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424192, encodeId=4f11142419296, content=<a href='/topic/show?id=94c182929d0' target=_blank style='color:#2F92EE;'>#肿瘤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82929, encryptionId=94c182929d0, topicName=肿瘤患者)], attachment=null, 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  5. [GetPortalCommentsPageByObjectIdResponse(id=1795416, encodeId=5b411e95416f0, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Feb 03 20:42:00 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763477, encodeId=b9711e6347777, content=<a href='/topic/show?id=3fc83035361' target=_blank style='color:#2F92EE;'>#内分泌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30353, encryptionId=3fc83035361, topicName=内分泌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=763a37536718, createdName=1249898am27暂无昵称, createdTime=Sun Aug 20 07:42:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682337, encodeId=d238168233ebf, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Wed Feb 28 22:42:00 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1932586, encodeId=eebe1932586b2, content=<a href='/topic/show?id=5cd95305803' target=_blank style='color:#2F92EE;'>#患者生存#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53058, encryptionId=5cd95305803, topicName=患者生存)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Mon Feb 19 21:42:00 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953712, encodeId=04411953e123a, content=<a href='/topic/show?id=9bdbe41946e' target=_blank style='color:#2F92EE;'>#神经内分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74194, encryptionId=9bdbe41946e, topicName=神经内分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Tue Oct 10 06:42:00 CST 2017, time=2017-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230357, encodeId=132f23035e2c, content=pNENs和胰腺癌都发生在胰腺,但这两种疾病的表现、治疗方法、治疗结果差别非常大。胰腺癌恶性程度极高,而pNENs则是为数不多的有希望治愈的胰腺肿瘤之一,所以罹患pNENs的患者一定不要放弃治疗!, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Aug 05 12:19:47 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230356, encodeId=a27a23035636, content=依据激素的分泌状态和患者的临床表现可分为功能性pNENs和无功能性pNENs。, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Aug 05 12:19:09 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230355, encodeId=dfdc230355ec, content=pNENs,pancreaticneuroendocrineneoplasm,即胰腺神经内分泌肿瘤, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Aug 05 12:18:49 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424192, encodeId=4f11142419296, content=<a href='/topic/show?id=94c182929d0' target=_blank style='color:#2F92EE;'>#肿瘤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82929, encryptionId=94c182929d0, topicName=肿瘤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=60943920553, createdName=lanyan20020087, createdTime=Sat Aug 05 10:42:00 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429411, encodeId=e439142941186, content=<a href='/topic/show?id=bb015438221' target=_blank style='color:#2F92EE;'>#手术切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54382, encryptionId=bb015438221, topicName=手术切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cfdd4195665, createdName=s_pl2009, createdTime=Sat Aug 05 10:42:00 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
  6. 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createdBy=763a37536718, createdName=1249898am27暂无昵称, createdTime=Sun Aug 20 07:42:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682337, encodeId=d238168233ebf, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Wed Feb 28 22:42:00 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1932586, encodeId=eebe1932586b2, content=<a href='/topic/show?id=5cd95305803' target=_blank style='color:#2F92EE;'>#患者生存#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53058, encryptionId=5cd95305803, topicName=患者生存)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Mon Feb 19 21:42:00 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953712, encodeId=04411953e123a, content=<a href='/topic/show?id=9bdbe41946e' target=_blank style='color:#2F92EE;'>#神经内分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74194, encryptionId=9bdbe41946e, topicName=神经内分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Tue Oct 10 06:42:00 CST 2017, time=2017-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230357, encodeId=132f23035e2c, content=pNENs和胰腺癌都发生在胰腺,但这两种疾病的表现、治疗方法、治疗结果差别非常大。胰腺癌恶性程度极高,而pNENs则是为数不多的有希望治愈的胰腺肿瘤之一,所以罹患pNENs的患者一定不要放弃治疗!, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Aug 05 12:19:47 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230356, encodeId=a27a23035636, content=依据激素的分泌状态和患者的临床表现可分为功能性pNENs和无功能性pNENs。, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Aug 05 12:19:09 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230355, encodeId=dfdc230355ec, content=pNENs,pancreaticneuroendocrineneoplasm,即胰腺神经内分泌肿瘤, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Aug 05 12:18:49 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424192, encodeId=4f11142419296, content=<a href='/topic/show?id=94c182929d0' target=_blank style='color:#2F92EE;'>#肿瘤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82929, encryptionId=94c182929d0, topicName=肿瘤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=60943920553, createdName=lanyan20020087, createdTime=Sat Aug 05 10:42:00 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429411, encodeId=e439142941186, content=<a href='/topic/show?id=bb015438221' target=_blank style='color:#2F92EE;'>#手术切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54382, encryptionId=bb015438221, topicName=手术切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cfdd4195665, createdName=s_pl2009, createdTime=Sat Aug 05 10:42:00 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-05 随梦飞扬

    pNENs和胰腺癌都发生在胰腺,但这两种疾病的表现、治疗方法、治疗结果差别非常大。胰腺癌恶性程度极高,而pNENs则是为数不多的有希望治愈的胰腺肿瘤之一,所以罹患pNENs的患者一定不要放弃治疗!

    0

  7. 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content=pNENs和胰腺癌都发生在胰腺,但这两种疾病的表现、治疗方法、治疗结果差别非常大。胰腺癌恶性程度极高,而pNENs则是为数不多的有希望治愈的胰腺肿瘤之一,所以罹患pNENs的患者一定不要放弃治疗!, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Aug 05 12:19:47 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230356, encodeId=a27a23035636, content=依据激素的分泌状态和患者的临床表现可分为功能性pNENs和无功能性pNENs。, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Aug 05 12:19:09 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authenticateStatus=null, createdAvatar=null, createdBy=60943920553, createdName=lanyan20020087, createdTime=Sat Aug 05 10:42:00 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429411, encodeId=e439142941186, content=<a href='/topic/show?id=bb015438221' target=_blank style='color:#2F92EE;'>#手术切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54382, encryptionId=bb015438221, topicName=手术切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cfdd4195665, createdName=s_pl2009, createdTime=Sat Aug 05 10:42:00 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-05 随梦飞扬

    依据激素的分泌状态和患者的临床表现可分为功能性pNENs和无功能性pNENs。

    0

  8. 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    2017-08-05 随梦飞扬

    pNENs,pancreaticneuroendocrineneoplasm,即胰腺神经内分泌肿瘤

    0

  9. 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content=pNENs和胰腺癌都发生在胰腺,但这两种疾病的表现、治疗方法、治疗结果差别非常大。胰腺癌恶性程度极高,而pNENs则是为数不多的有希望治愈的胰腺肿瘤之一,所以罹患pNENs的患者一定不要放弃治疗!, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Aug 05 12:19:47 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230356, encodeId=a27a23035636, content=依据激素的分泌状态和患者的临床表现可分为功能性pNENs和无功能性pNENs。, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Aug 05 12:19:09 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230355, encodeId=dfdc230355ec, content=pNENs,pancreaticneuroendocrineneoplasm,即胰腺神经内分泌肿瘤, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Aug 05 12:18:49 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424192, encodeId=4f11142419296, content=<a href='/topic/show?id=94c182929d0' target=_blank style='color:#2F92EE;'>#肿瘤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82929, encryptionId=94c182929d0, topicName=肿瘤患者)], attachment=null, 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