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Nat Commun：根据小鼠关节炎发作情况响应的释药凝胶

2018-04-05佚名Nature自然科研

关节炎 释药凝胶 模型
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本周《自然-通讯》论文Towards an arthritis flare-responsive drug delivery system发表一种小鼠模型，展示了一种响应炎症性关节炎的疾病活动性的释药凝胶。

本周《自然-通讯》论文Towards an arthritis flare-responsive drug delivery system发表一种小鼠模型，展示了一种响应炎症性关节炎的疾病活动性的释药凝胶。



三聚甘油单硬脂酸酯（TG-18）自组装形成关节炎响应性水凝胶。

炎症性关节炎患者的疾病活动性有一阵子低，有一阵子高，高的时候也被称为疾病发作。传递剂量保持不变的药物的治疗方法无法应对和适应这些活动变化，因此在疾病活动性的循环过程中，可能无法达到最优用量。

美国布莱根妇女医院的Jeffrey Karp及同事通过研发一种响应发作的水凝胶，试图解决疾病活动性和药物剂量之间的不匹配。在炎症性关节炎的细胞和小鼠模型中，当凝胶接触到关节炎相关的酶时，凝胶分解。凝胶可装载不同的小分子，它可根据疾病发作的严重程度释放相应量的药物。当凝胶装载一种用于治疗关节炎的皮质类固醇时，可观察到关节炎活动性降低。



TG-18凝胶的分解与关节炎严重程度相关。

作者称，响应性水凝胶是一种潜在的治疗炎症性关节炎的有效方法。但他们也谨慎提出，需要更多的研究来优化凝胶的成分，并有必要在有人类大小关节的大型动物上测试，之后才可以考虑可能的人类 临床试验。作者总结，这或许是设计响应疾病活动性的治疗方案的第一步。

原始出处：
Nitin Joshi, Jing Yan, Seth Levy, et al. Towards an arthritis flare-responsive drug delivery system.Nature Communications. 03 April 2018.

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    2019-01-10 liye789132251

    #Nat#

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    #关节炎#

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    2018-04-07 lishizhe

    #凝胶#

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    2018-04-05 329523732

    不错

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