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Am J Kidney Dis：IgA肾病患者妊娠及肾脏结局如何？

2017-03-21 xing.T MedSci原创

IgAN妊娠肾脏结局
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由此可见，妊娠会加速IgAN以及CKD 3期女性肾脏疾病的进展速度，但不会加快CKD 1或2期患者肾脏疾病的进展速度。

IgA肾病（IgAN）的妊娠结局是有争议的。近日，肾脏病领域权威杂志Am J Kidney Dis上发表了一篇研究文章。该队列研究评估了妊娠对IgAN患者肾脏疾病的进展和不良妊娠结局危险因素的影响。

该研究的参与者为育龄IgAN妇女，在2003年12月至2014年9月期间至少随访一年。研究人员将妊娠作为一个随时间变化的变量；测定了基础（活检时间）估计的肾小球滤过率（eGFR）、蛋白尿、血压和肾脏病理等指标。研究结局为肾脏疾病进展事件，其被定义为eGFR下降30%或终末期肾脏疾病；eGFR下降率；不良妊娠结局，包括重度子痫前期和流产。

在413例招募的患者中，慢性肾脏病（CKD）1、2、3和4期的患者分别有266名（64.4%）、101名（24.5%）、40名（9.6%）和6名（1.5%）。在随访期间，104名参与者共有116次妊娠，其中110次妊娠持续超过20周，309例患者没有怀孕。调整年龄、EGFR、平均动脉压、尿蛋白和活检时病理组织类型后，研究人员发现在CKD3期到4期的患者，而不是CKD1期到2期患者，随后的妊娠与更快的eGFR下降（-7.44 vs. -3.90ml/min/1.73m2每年；P=0.007）和增加的肾脏进展事件发生率（风险比为5.14；95%可信区间为1.16-22.74）有关，相比于没有怀孕的患者。

由此可见，妊娠会加速IgAN以及CKD 3期女性肾脏疾病的进展速度，但不会加快CKD 1或2期患者肾脏疾病的进展速度。

原始出处：

Xiaole Su, et al. Pregnancy and Kidney Outcomes in Patients With IgA Nephropathy: A Cohort Study. Am J Kidney Dis.2017. http://dx.doi.org/10.1053/j.ajkd.2017.01.043

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    2018-01-16 cmj8wellington

    #Dis#

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    2017-11-05 gostraight

    #肾病患者#

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    2018-01-03 lanyan20020086

    #IgA肾病患者#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2012184, encodeId=beba2012184e9, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue Jan 16 00:57:00 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025803, encodeId=b8e12025803dd, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Sun Nov 05 20:57:00 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028109, encodeId=0c9f202810928, content=<a href='/topic/show?id=99ff9483cd' target=_blank style='color:#2F92EE;'>#IgA肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9483, encryptionId=99ff9483cd, topicName=IgA肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ee7414, createdName=lanyan20020086, createdTime=Wed Jan 03 18:57:00 CST 2018, time=2018-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414597, encodeId=feb5141459eee, content=<a href='/topic/show?id=c83e94827d' target=_blank style='color:#2F92EE;'>#IgA肾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9482, encryptionId=c83e94827d, topicName=IgA肾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7c3073380, createdName=huiwelcome, createdTime=Thu Mar 23 08:57:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1428682, encodeId=db3614286821c, content=<a href='/topic/show?id=71b182e3237' target=_blank style='color:#2F92EE;'>#肾脏结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82732, encryptionId=71b182e3237, topicName=肾脏结局)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76614125796, createdName=szhvet, createdTime=Thu Mar 23 08:57:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503895, encodeId=3fff1503895e6, content=<a href='/topic/show?id=641d94e7eb' target=_blank style='color:#2F92EE;'>#IgA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9477, encryptionId=641d94e7eb, topicName=IgA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c23f9697922, createdName=yibei, createdTime=Thu Mar 23 08:57:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603014, encodeId=d83016030148e, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e18990621, createdName=gwc389, createdTime=Thu Mar 23 08:57:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181967, encodeId=5cf418196e0e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kwey8sPz6kF2ticbWG0qo1CGl5YvXLjkxb3yib7G2mCqNMf2vOBSLIQ5NtfiajK6ctCsbicTFeV3Wiapib/0, createdBy=f9072039248, createdName=朱朱*^_^*, createdTime=Wed Mar 22 17:07:32 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181735, encodeId=17c7181e3544, content=妊娠会加速IgAN以及CKD 3期女性肾脏疾病的进展速度，但不会加快CKD 1或2期患者肾脏疾病的进展速度, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Tue Mar 21 20:07:17 CST 2017, time=2017-03-21, status=1, ipAttribution=)]
    2017-03-23 huiwelcome

    #IgA肾病#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2012184, encodeId=beba2012184e9, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue Jan 16 00:57:00 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025803, encodeId=b8e12025803dd, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Sun Nov 05 20:57:00 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028109, encodeId=0c9f202810928, content=<a href='/topic/show?id=99ff9483cd' target=_blank style='color:#2F92EE;'>#IgA肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9483, encryptionId=99ff9483cd, topicName=IgA肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ee7414, createdName=lanyan20020086, createdTime=Wed Jan 03 18:57:00 CST 2018, time=2018-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414597, encodeId=feb5141459eee, content=<a href='/topic/show?id=c83e94827d' target=_blank style='color:#2F92EE;'>#IgA肾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9482, encryptionId=c83e94827d, topicName=IgA肾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7c3073380, createdName=huiwelcome, createdTime=Thu Mar 23 08:57:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1428682, encodeId=db3614286821c, content=<a href='/topic/show?id=71b182e3237' target=_blank style='color:#2F92EE;'>#肾脏结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82732, encryptionId=71b182e3237, topicName=肾脏结局)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76614125796, createdName=szhvet, createdTime=Thu Mar 23 08:57:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503895, encodeId=3fff1503895e6, content=<a href='/topic/show?id=641d94e7eb' target=_blank style='color:#2F92EE;'>#IgA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9477, encryptionId=641d94e7eb, topicName=IgA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c23f9697922, createdName=yibei, createdTime=Thu Mar 23 08:57:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603014, encodeId=d83016030148e, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e18990621, createdName=gwc389, createdTime=Thu Mar 23 08:57:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181967, encodeId=5cf418196e0e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kwey8sPz6kF2ticbWG0qo1CGl5YvXLjkxb3yib7G2mCqNMf2vOBSLIQ5NtfiajK6ctCsbicTFeV3Wiapib/0, createdBy=f9072039248, createdName=朱朱*^_^*, createdTime=Wed Mar 22 17:07:32 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181735, encodeId=17c7181e3544, content=妊娠会加速IgAN以及CKD 3期女性肾脏疾病的进展速度，但不会加快CKD 1或2期患者肾脏疾病的进展速度, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Tue Mar 21 20:07:17 CST 2017, time=2017-03-21, status=1, ipAttribution=)]
    2017-03-23 szhvet

    #肾脏结局#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2012184, encodeId=beba2012184e9, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue Jan 16 00:57:00 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025803, encodeId=b8e12025803dd, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Sun Nov 05 20:57:00 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028109, encodeId=0c9f202810928, content=<a href='/topic/show?id=99ff9483cd' target=_blank style='color:#2F92EE;'>#IgA肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9483, encryptionId=99ff9483cd, topicName=IgA肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ee7414, createdName=lanyan20020086, createdTime=Wed Jan 03 18:57:00 CST 2018, time=2018-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414597, encodeId=feb5141459eee, content=<a href='/topic/show?id=c83e94827d' target=_blank style='color:#2F92EE;'>#IgA肾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9482, encryptionId=c83e94827d, topicName=IgA肾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7c3073380, createdName=huiwelcome, createdTime=Thu Mar 23 08:57:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1428682, encodeId=db3614286821c, content=<a href='/topic/show?id=71b182e3237' target=_blank style='color:#2F92EE;'>#肾脏结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82732, encryptionId=71b182e3237, topicName=肾脏结局)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76614125796, createdName=szhvet, createdTime=Thu Mar 23 08:57:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503895, encodeId=3fff1503895e6, content=<a href='/topic/show?id=641d94e7eb' target=_blank style='color:#2F92EE;'>#IgA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9477, encryptionId=641d94e7eb, topicName=IgA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c23f9697922, createdName=yibei, createdTime=Thu Mar 23 08:57:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603014, encodeId=d83016030148e, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e18990621, createdName=gwc389, createdTime=Thu Mar 23 08:57:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181967, encodeId=5cf418196e0e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kwey8sPz6kF2ticbWG0qo1CGl5YvXLjkxb3yib7G2mCqNMf2vOBSLIQ5NtfiajK6ctCsbicTFeV3Wiapib/0, createdBy=f9072039248, createdName=朱朱*^_^*, createdTime=Wed Mar 22 17:07:32 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181735, encodeId=17c7181e3544, content=妊娠会加速IgAN以及CKD 3期女性肾脏疾病的进展速度，但不会加快CKD 1或2期患者肾脏疾病的进展速度, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Tue Mar 21 20:07:17 CST 2017, time=2017-03-21, status=1, ipAttribution=)]
    2017-03-23 yibei

    #IgA#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2012184, encodeId=beba2012184e9, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue Jan 16 00:57:00 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025803, encodeId=b8e12025803dd, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Sun Nov 05 20:57:00 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028109, encodeId=0c9f202810928, content=<a href='/topic/show?id=99ff9483cd' target=_blank style='color:#2F92EE;'>#IgA肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9483, encryptionId=99ff9483cd, topicName=IgA肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ee7414, createdName=lanyan20020086, createdTime=Wed Jan 03 18:57:00 CST 2018, time=2018-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414597, encodeId=feb5141459eee, content=<a href='/topic/show?id=c83e94827d' target=_blank style='color:#2F92EE;'>#IgA肾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9482, encryptionId=c83e94827d, topicName=IgA肾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7c3073380, createdName=huiwelcome, createdTime=Thu Mar 23 08:57:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1428682, encodeId=db3614286821c, content=<a href='/topic/show?id=71b182e3237' target=_blank style='color:#2F92EE;'>#肾脏结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82732, encryptionId=71b182e3237, topicName=肾脏结局)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76614125796, createdName=szhvet, createdTime=Thu Mar 23 08:57:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503895, encodeId=3fff1503895e6, content=<a href='/topic/show?id=641d94e7eb' target=_blank style='color:#2F92EE;'>#IgA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9477, encryptionId=641d94e7eb, topicName=IgA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c23f9697922, createdName=yibei, createdTime=Thu Mar 23 08:57:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603014, encodeId=d83016030148e, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e18990621, createdName=gwc389, createdTime=Thu Mar 23 08:57:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181967, encodeId=5cf418196e0e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kwey8sPz6kF2ticbWG0qo1CGl5YvXLjkxb3yib7G2mCqNMf2vOBSLIQ5NtfiajK6ctCsbicTFeV3Wiapib/0, createdBy=f9072039248, createdName=朱朱*^_^*, createdTime=Wed Mar 22 17:07:32 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181735, encodeId=17c7181e3544, content=妊娠会加速IgAN以及CKD 3期女性肾脏疾病的进展速度，但不会加快CKD 1或2期患者肾脏疾病的进展速度, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Tue Mar 21 20:07:17 CST 2017, time=2017-03-21, status=1, ipAttribution=)]
    2017-03-23 gwc389

    #kidney#

    0

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    2017-03-22 朱朱*^_^*

    学习了

    0

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    2017-03-21 knowheart

    妊娠会加速IgAN以及CKD 3期女性肾脏疾病的进展速度，但不会加快CKD 1或2期患者肾脏疾病的进展速度

    0

相关威廉亚洲官网

JASN：IgAN患者通常会有更好的预后

　　2012年9月6号，西班牙研究人员发现肾功能正常且无血尿、蛋白尿的IgAN患者长期预后效果理想，该研究结果在线发表于《美国肾脏学会杂志》上（J Am Soc Nephrol. 2012 Sep 6.）。   　　按照惯例，肾脏病医生将对高水平蛋白尿（尿蛋白，1-2 g/d）患者进行肾活检。西班牙已有8家医院为轻度异常患者采用肾活检，因此Eduardo Gutiérrez博士和他的