Acta Anaesthesiol Scand:机器人辅助腹腔镜前列腺切除术中不同全麻药对心室复极的影响

2020-07-15 “罂粟花”微信号 “罂粟花”微信号

背景与目的

背景与目的

不同类型的麻醉药物对心室复极可产生不同的影响。本研究旨在比较不同种类全麻药物在机器人辅助腹腔镜根治性前列腺切除术(RALP)中对心室复极的影响。

方 法

69例患者随机分为七氟醚组(七氟醚/瑞芬太尼)、地氟醚组(地氟醚/瑞芬太尼)和全凭静脉麻醉组(丙泊酚/瑞芬太尼),但只有67例患者完成研究。主要结果是在RALP期间的9个时间点收集的心率校正QT(QTc)间期。QT间期校正采用Bazett公式(QTcB)和Fridericia公式(QTcF)。次要结果为在同一时间点采集的Tpeak-Tend间期(Tp-e)和Tp-e/QT比值。

结 果

术中各组的QTcB和QTcF间期均明显延长,但随着时间推移,这些值表现出明显的组间差异。采用头低脚高位后,地氟醚组QTcB和QTcF间期明显长于其他两组,并持续到手术结束。术中地氟醚组有6例患者QTcB间期和5例患者QTcF间期分别超过450ms,而TIVA组无一例出现QTcB和QTcF间期超过450ms。而且,术中地氟醚组QTc间期延长>20ms和>60ms的发生率明显高于TIVA组。术中三组Tp-e间期和Tp-e/QT比值无显着差异。

结 论

为了最大限度减少RALP期间QTc间期延长,建议采用丙泊酚/瑞芬太尼全凭静脉麻醉。

原始出处:

Park JH, Lee KY, Choi YD, et al. Effect of different general anaesthetics on ventricular repolarisation in robot-assisted laparoscopic prostatectomy.[J].Acta Anaesthesiol Scand 2020 Jun 12,10.1111/aas.13653.

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    2021-06-06 AspirantSuo
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encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun Sep 27 15:43:25 CST 2020, time=2020-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708863, encodeId=70c11e08863fd, content=<a href='/topic/show?id=ffca32501e6' target=_blank style='color:#2F92EE;'>#前列腺切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32501, encryptionId=ffca32501e6, topicName=前列腺切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbe731571573, createdName=1249898am25暂无昵称, createdTime=Sun Feb 14 20:43:25 CST 2021, time=2021-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051583, encodeId=b9b82051583c9, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sat Sep 12 14:43:25 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276470, encodeId=cd9e12e64701a, content=<a href='/topic/show?id=768685612db' target=_blank style='color:#2F92EE;'>#腹腔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85612, encryptionId=768685612db, topicName=腹腔镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Fri Jul 17 07:43:25 CST 2020, time=2020-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1322113, encodeId=3167132211378, content=<a href='/topic/show?id=890c611854e' target=_blank style='color:#2F92EE;'>#机器人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61185, encryptionId=890c611854e, topicName=机器人)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Fri Jul 17 07:43:25 CST 2020, time=2020-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1476594, encodeId=33e514e659428, content=<a href='/topic/show?id=6ff229e7126' target=_blank style='color:#2F92EE;'>#全麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29771, encryptionId=6ff229e7126, topicName=全麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Fri Jul 17 07:43:25 CST 2020, time=2020-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513339, encodeId=2c99151333914, content=<a href='/topic/show?id=6a446120454' target=_blank style='color:#2F92EE;'>#机器人辅助#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61204, encryptionId=6a446120454, topicName=机器人辅助)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=324410545094, createdName=124987a0m69(暂无昵称), createdTime=Fri Jul 17 07:43:25 CST 2020, time=2020-07-17, status=1, ipAttribution=)]
    2020-09-27 windight
  5. 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  6. 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  7. 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  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513339, encodeId=2c99151333914, content=<a href='/topic/show?id=6a446120454' target=_blank style='color:#2F92EE;'>#机器人辅助#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61204, encryptionId=6a446120454, topicName=机器人辅助)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=324410545094, createdName=124987a0m69(暂无昵称), createdTime=Fri Jul 17 07:43:25 CST 2020, time=2020-07-17, status=1, ipAttribution=)]
    2020-07-17 xue8602
  9. 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最近,有研究人员评估了根治性前列腺切除术前进行多参数前列腺核磁共振成像(MP-MRI)的诊断价值,目的是检测筛状结构(CA)与导管内前列腺癌(IDC)情况,这些最近被报道是不良的病理因素。研究包括了124名男性,他们在根治性前列腺切除前经历了MP-MRI。研究人员对他们的术前MP-MRI、前列腺切除组织学和临床跟踪调查细节进行了回顾。研究发现,根治性前列腺切除样本的病理学检查在124个案例中的89