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Heart：炎症标志物浓度升高与冠脉钙化增加相关

2015-01-07 高晓方 译 医学论坛网

炎症标志物冠脉钙化
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美国一项研究表明，在无症状健康成人中，抗热休克蛋白60(抗-HSP60)和白介素2(IL-2)浓度升高与冠脉钙化(CAC)增加具有相关性。论文1月5日在线发表于《心脏》(Heart)杂志。 此项研究共纳入998例年龄为45～84岁的无症状性成人受试者，并且受试者均无已知冠脉疾病。在基线时测定抗-HSP60，并评估血清抗-HSP60三分位数。对冠脉危险因素和Framingham风险评分进行

美国一项研究表明，在无症状健康成人中，抗热休克蛋白60(抗-HSP60)和白介素2(IL-2)浓度升高与冠脉钙化(CAC)增加具有相关性。论文1月5日在线发表于《心脏》(Heart)杂志。

此项研究共纳入998例年龄为45～84岁的无症状性成人受试者，并且受试者均无已知冠脉疾病。在基线时测定抗-HSP60，并评估血清抗-HSP60三分位数。对冠脉危险因素和Framingham风险评分进行校正之后，利用多变量分析评估IL-2和抗-HSP60与CAC的相关性。

结果显示，抗-HSP60水平不同患者的人口统计学数据、糖尿病、高血压、肥胖和血脂异常均无差异。抗-HSP60低、中、高三分位人群的中位Framingham风险评分分别为11、8和9(P=0.043)。

IL-2和TNF-α与CAC评分增加具有相关性。高三分位数抗-HSP60和IL-2与CAC风险升高具有相关性。在基线抗-HSP60和IL-2水平较高者中可观察到CAC显著进展。

原始出处：

Abdulla A Damluji1, Archana Ramireddy1, Mohammed S Al-Damluji2, George R Marzouka1, Lynda Otalvaro1, Juan F Viles-Gonzalez1, Chunming Dong1, Carlos E Alfonso1, Robert C Hendel1, Mauricio G Cohen1, Mauro Moscucci1, Nanette H Bishopric1, Robert J Myerburg1.Association between anti-human heat shock protein-60 and interleukin-2 with coronary artery calcium score.Heart doi:10.1136/heartjnl-2014-306649

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    2015-09-04 ms7405317358118777

    #炎症标志物#

    0

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    2015-09-03 hukaixun

    #标志物#

    0

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    2015-01-09 zhaojie88

    #ART#

    0

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    2015-01-09 d830375

    #冠脉钙化#

    0

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    2015-01-09 12498974m55暂无昵称

    #浓度#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1764819, encodeId=eb051e6481930, content=<a href='/topic/show?id=cb0d6e045dc' target=_blank style='color:#2F92EE;'>#炎症标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67045, encryptionId=cb0d6e045dc, topicName=炎症标志物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b9437807464, createdName=ms7405317358118777, createdTime=Fri Sep 04 18:07:00 CST 2015, time=2015-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840827, encodeId=d78b184082ef3, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Thu Sep 03 19:07:00 CST 2015, time=2015-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355950, encodeId=2a50135595086, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jan 09 02:07:00 CST 2015, time=2015-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1487185, encodeId=23a9148e18532, content=<a href='/topic/show?id=624831013b1' target=_blank style='color:#2F92EE;'>#冠脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31013, encryptionId=624831013b1, topicName=冠脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16808291789, createdName=d830375, createdTime=Fri Jan 09 02:07:00 CST 2015, time=2015-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544395, encodeId=d5b8154439503, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Fri Jan 09 02:07:00 CST 2015, time=2015-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562277, encodeId=793715622e733, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Fri Jan 09 02:07:00 CST 2015, time=2015-01-09, status=1, ipAttribution=)]
    2015-01-09 爆笑小医

    #HEART#

    0