Neurology:肾损伤对接受血管内再通患者临床结局的影响

2019-12-20 xing.T MedSci原创

由此可见,该研究的结果表明RI是接受EVT治疗的ELVO患者3个月功能独立性和卒中复发长期风险的独立预测因子。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在明确并接受急诊血管内治疗(EVT)的急诊大血管闭塞(ELVO)患者肾损伤(RI)对3个月临床结局以及复发性卒中风险的影响。

研究人员纳入了21个血管内治疗中心连续就诊接受EVT治疗的ELVO患者。多变量回归用于评估RI与3个月时死亡率、功能独立性(改良的Rankin量表[mRS]评分为0-2)和功能改善(mRS评分变化)之间的相关性。通过多变量竞争风险回归分析评估了RI与复发性卒中风险之间的相关性。

该研究共有628例ELVO患者(平均年龄为64.7±12.5岁,NIH卒中量表中位数得分为17分,其中99例[15.8%]患者存在RI)接受了EVT。在对其他相关变量进行调整后,多元回归分析表明,RI与3个月功能独立性独立相关(调整后的比值比为0.53,95%置信区间[CI]为0.29-0.96,p=0.035),而与死亡率或功能改善无关。多元竞争风险回归分析显示,接受EVT的RI患者与正常肾功能的患者相比,发生卒中的风险更高(调整后的风险比为2.56,95%CI为1.27-5.18,p=0.009)。

由此可见,该研究的结果表明RI是接受EVT治疗的ELVO患者3个月功能独立性和卒中复发长期风险的独立预测因子。 

原始出处:

Lulu Xiao,et al.Renal impairment on clinical outcomes following endovascular recanalization.Neurology.2019.https://doi.org/10.1212/WNL.0000000000008748

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