Hypertension:动脉僵硬度对COVID-19住院患者全因死亡率的影响

2021-01-05 MedSci原创 MedSci原创

该研究的数据表明AS和入院SBP<120 mmHg对COVID-19住院患者的全因死亡率具有预测价值。

老年和血管合并症是COVID-19患者全因死亡已知的危险因素,而高血压和年龄是动脉僵硬(AS)两个主要决定因素。近日,心血管权威杂志Hypertension上发表了一篇研究文章,这项研究旨在评估需要住院的COVID-19患者AS负担,并分析其与全因住院死亡之间的关系。

这项观察性、回顾性、多中心队列研究分析了COVID-19网络中150个西班牙中心的12170名患者。研究人员比较了COVID-19幸存者与非幸存者之间AS(定义为脉压≥60 mmHg)的临床特征。

受试者平均年龄为67.5±16.1岁,女性占42.5%。总体而言,有2606名(21.4%)受试者死亡。入院收缩压(SBP)<120以及≥140mmHg是全因死亡率更高的预测指标(分别为23.5%和22.8%,p<0.001),相比于BP=120-140mmHg(18.6%)。4379名(36.0%)AS患者年龄较大,收缩压较高,舒张压较低。多变量分析显示,在对性别(男性,ORadj为1.6,p=0.0001)、年龄三分位数(第二和第三分位数ORadj分别为2.0和4.7,p=0.0001)、查尔森合并症指数(第二和第三分位数ORadj分别为4.8和8.6,p=0.0001)、心力衰竭以及既往和住院降压治疗进行了调整后,AS和SBP<120mmHg可显著并独立预测了住院患者的全因死亡率(ORadj为1.27,p=0.0001;ORadj为1.48,p=0.0001)。

由此可见,该研究的数据表明AS和入院SBP<120 mmHg对COVID-19住院患者的全因死亡率具有预测价值。

原始出处:

Enrique Rodilla.et al.Impact of arterial stiffness on all-cause mortality in patients hospitalized with COVID-19 in Spain.Hypertension.2021.https://doi.org/10.1161/HYPERTENSIONAHA.120.16563

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    2021-01-06 zb1235672

    #新冠肺炎#值得学习!

    0

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