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Biosci Rep：研究揭示RNA DANCR在人滑膜间充质干细胞软骨形成分化的机制

2017-09-24 MedSci MedSci原创

RNADANCR软骨形成
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研究已经发现miRNA可通过调节多种信号通路来调节细胞分化。长链非编码RNA（lnc RNA）DANCR被认为是人类滑膜间充质干细胞（SMSC）的软骨形成的关键，然而，其潜在的分子机制目前尚未清楚。本研究中个，研究人员发现，SMSCs中DANCR的miRNA表达谱过表达确定miR-1305明显下调，而miR-1305是DANCR的下游靶标。值得注意的是，miR-1305过表达逆转了DANCR诱导的

研究已经发现miRNA可通过调节多种信号通路来调节细胞分化。长链非编码RNA（lnc RNA）DANCR被认为是人类滑膜间充质干细胞（SMSC）的软骨形成的关键，然而，其潜在的分子机制目前尚未清楚。

本研究中个，研究人员发现，SMSCs中DANCR的miRNA表达谱过表达确定miR-1305明显下调，而miR-1305是DANCR的下游靶标。值得注意的是，miR-1305过表达逆转了DANCR诱导的SMSCs细胞增殖和软骨形成分化，表明miR-1305拮抗了DANCR的功能。


具体来说， miR-1305的高表达导致TGF-β通路成员Smad4的表达降低，抑制miR-1305则会升高Smad4的表达水平。Smad4的消耗抑制了DANCR在SMSCs细胞增殖和软骨形成中的促进作用。

总之，该研究结果表明miR-1305-Smad4轴作为lncRNA DANCR的主要下游单位，促进SMSCs中软骨的形成。

原始出处：

Lei Zhang, Xiangyi Sun, et al., Long noncoding RNA DANCR regulates miR-1305-Smad 4 axis to promote chondrogenic differentiation of human synovium-derived mesenchymal stem cells. Biosci Rep. 2017 Aug 31; 37(4): BSR20170347. Prepublished online 2017 Jul 3. Published online 2017 Jul 21. doi: 10.1042/BSR20170347

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    2018-01-28 12498561m32(暂无昵称)

    #DANCR#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2005897, encodeId=a839200589ecb, content=<a href='/topic/show?id=f1ee56e6e1' target=_blank style='color:#2F92EE;'>#DANCR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5676, encryptionId=f1ee56e6e1, topicName=DANCR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d81c2500028, createdName=12498561m32(暂无昵称), createdTime=Sun Jan 28 12:17:00 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917676, encodeId=798b191e67604, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Aug 03 09:17:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815267, encodeId=a74b181526e19, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Wed Apr 25 14:17:00 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247537, encodeId=363e24e537e2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Mon Sep 25 09:11:13 CST 2017, time=2017-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247395, encodeId=b58a24e3953d, content=谢谢分享.学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Mon Sep 25 00:19:07 CST 2017, time=2017-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247385, encodeId=723324e385bb, content=谢谢分享.感觉收获很大!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Sep 24 23:51:53 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2018-08-03 sunylz

    #Bio#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2005897, encodeId=a839200589ecb, content=<a href='/topic/show?id=f1ee56e6e1' target=_blank style='color:#2F92EE;'>#DANCR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5676, encryptionId=f1ee56e6e1, topicName=DANCR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d81c2500028, createdName=12498561m32(暂无昵称), createdTime=Sun Jan 28 12:17:00 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917676, encodeId=798b191e67604, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Aug 03 09:17:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815267, encodeId=a74b181526e19, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Wed Apr 25 14:17:00 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247537, encodeId=363e24e537e2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Mon Sep 25 09:11:13 CST 2017, time=2017-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247395, encodeId=b58a24e3953d, content=谢谢分享.学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Mon Sep 25 00:19:07 CST 2017, time=2017-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247385, encodeId=723324e385bb, content=谢谢分享.感觉收获很大!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Sep 24 23:51:53 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2018-04-25 h.y200607_23674418

    #间充质干细#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2005897, encodeId=a839200589ecb, content=<a href='/topic/show?id=f1ee56e6e1' target=_blank style='color:#2F92EE;'>#DANCR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5676, encryptionId=f1ee56e6e1, topicName=DANCR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d81c2500028, createdName=12498561m32(暂无昵称), createdTime=Sun Jan 28 12:17:00 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917676, encodeId=798b191e67604, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Aug 03 09:17:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815267, encodeId=a74b181526e19, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Wed Apr 25 14:17:00 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247537, encodeId=363e24e537e2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Mon Sep 25 09:11:13 CST 2017, time=2017-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247395, encodeId=b58a24e3953d, content=谢谢分享.学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Mon Sep 25 00:19:07 CST 2017, time=2017-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247385, encodeId=723324e385bb, content=谢谢分享.感觉收获很大!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Sep 24 23:51:53 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2017-09-25 llaq

    学习

    0

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    2017-09-25 明天会更好！

    谢谢分享.学习了!

    0

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    2017-09-24 明天会更好！

    谢谢分享.感觉收获很大!

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