Clin Respir J:AR与NAR患者的血清瘦素差异及血清瘦素的诊断价值

2021-09-12 AlexYang MedSci原创

比较了过敏性鼻炎(AR)和非过敏性鼻炎(NAR)患者的血清瘦素水平,并评估了瘦素的诊断价值情况。

鼻炎即鼻腔内膜炎症,症状包括瘙痒、鼻出血及鼻塞。根据皮刺或血清特异性免疫球蛋白E(IgE)测试,结合症状表现,鼻炎可分为过敏性鼻炎(AR)和非过敏性鼻炎(NAR)。来自美国和欧洲的研究估计,7%-19%的成人患有NAR。

瘦素可能在气道炎症中存在关键作用。然而,很少有研究评估它在不同病因鼻炎中的作用

近期,来自土耳其的研究人员在《Clin Respir J》杂志上发表文章,比较了过敏性鼻炎(AR)和非过敏性鼻炎(NAR)患者的血清瘦素水平,并评估了瘦素的诊断价值情况

研究人员对慢性鼻炎患者进行了皮刺测试(ALK-Abello/Madrid)和血清特异性免疫球蛋白E测试(UniCAP 100-Pharmacia),并结合症状对患者进行了分类。

研究共招募了398名患者,平均年龄为29.03岁,分为AR和NAR两组。结果发现,无论有无哮喘,NAR和AR患者的平均血清瘦素水平相似,但两组中的女性患者血清瘦素水平明显高于男性。另外,在AR患者中,肥胖患者的瘦素水平明显高于非肥胖患者。在相关性分析中,瘦素水平与女性性别、较大年龄和高体重指数(BMI)有关。与NAR患者相比,尽管AR患者的鼻部症状总分(TNSS)更高,但瘦素水平与TNSS、症状的严重程度和季节性以及过敏原的致敏性没有关联。

AR组与NAR组的血清瘦素分析

在逻辑回归分析中,发现较小的年龄和高血清瘦素水平是诊断AR的独立预测因素

过敏性鼻炎风险因素分析

综上所述,高BMI的女性更容易患AR。另外,瘦素作为区分AR和NAR的诊断工具价值有限

原始出处:

Ayse Fusun Kalpaklıoglu , Ayşe Baccioglu , Sümeyra Alan Yalim et al. Does serum leptin levels differ between patients with rhinitis of allergic versus nonallergic aetiology? Clin Respir J. Aug 2021

 

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    2021-09-14 sodoo
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    2021-09-12 周峰

    学习

    0

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