Alzheimer's dementia：认知正常的黑人、白人的阿尔茨海默病生物标志物纵向变化存在差异

2022-03-07 影像小生 MedSci原创

认知正常的黑人、白人的阿尔茨海默病生物标志物纵向变化存在差异

阿尔茨海默病 (AD) 是一种不可逆的神经退行性疾病，影响约 600 万美国人，预计到 2050 年，病例数将增加一倍以上。解决这一公共危机的解决方案要求对所有人（包括代表性不足的群体）都有效的预防和/或治疗方案。在没有可以改变 AD 进展的真正有效的治疗方法的情况下，预防可能是遏制公共卫生危机的唯一可行选择。为了设计 AD 预防试验，生物标志物对于建立适当的纳入/排除标准和跟踪疾病进展非常重要。

几乎所有这些重要的发现是基于白人为主的群体，很少有研究AD生物标志物的种族差异。了解 AD 生物标志物的纵向种族差异对于预防/干预试验的优化设计至关重要，以确保治疗有益于代表性不足群体。

阿尔茨海默病 (AD) 生物标志物包括脑脊液 (CSF) 指标、正电子发射断层扫描 (PET) 的淀粉样蛋白摄取、磁共振成像 (MRI) 的结构变化和认知等，目前其纵向变化尚未在黑人和白人之间进行比较。

Chengjie Xiong等在Alzheimer's & dementia杂志发表题为Racial differences in longitudinal Alzheimer's disease biomarkers among cognitively normal adults的研究文章，分析了阿尔茨海默病 (AD) 生物标志物在黑人和白人之间的差异。

该研究中，共有 179 名黑人和 1180 名白人在基线时认知正常，并且有来自至少一种生物标志物模式的纵向数据，研究团队对他们的年变化率进行了分析。

生物标志物估计年变化率在黑白人之间的差异

黑人比白人的CSF β 淀粉样蛋白 (Aβ)42/Aβ40 下降较慢 (P =0.0390)，淀粉样蛋白 (PET) 积累较慢 (P = 0.0157)。

生物标志物纵向轨迹的模型拟合图

CSF Aβ42 在黑人和白人之间随着时间的推移向相反的方向变化 (P = 0.0039)。黑人 CSF 总 tau 和磷酸化 tau181 的年增幅约为白人的一半。

总之，该团队观察到淀粉样蛋白生物标志物的纵向种族差异。全面和前瞻性地检查载脂蛋白 E 基因型和社会文化因素对这些差异的影响将非常重要。该研究结果可能会为未来 AD 预防试验的设计提供关于最佳生物标志物目标、干预时间窗、结果测量、纳入/排除标准和统计数据的信息。

原文出处

Xiong, Chengjie et al. “Racial differences in longitudinal Alzheimer's disease biomarkers among cognitively normal adults.” Alzheimer's & dementia : the journal of the Alzheimer's Association, 10.1002/alz.12608. 25 Feb. 2022, doi:10.1002/alz.12608

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2022-05-03 hukaixun

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2022-08-22 仁心济世

#dementia#

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2023-02-12 12498da4m32(暂无昵称)

#阿尔茨海#

58 0
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2022-11-01 ms1948154235210413

#阿尔茨#

73 0
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2022-03-08 ms2000000733738787

早日攻克#阿尔兹海默症#

124 0
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2022-03-03 yhj-time

#阿尔茨海默#

55 0
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2022-03-03 zhu_jun9842

#生物标志#

63 0
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2022-03-03 zhu_jun9842

#生物标志#

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