JACC:左房梗塞对心房重塑的影响

2017-12-10 MedSci MedSci原创

目前,对心梗后的左房重塑的认识尚浅。本研究的目的旨在利用心肌梗塞的猪模型来评估左房结构重塑的能力,并阐明左房重塑是如何影响二尖瓣返流的进展。本研究共建立了3个动物模型:1) 近端左回旋支(LCX)包括左房分支冠状动脉闭塞(左房梗塞组);2)近端左回旋支(LCX)不包括左房分支冠状动脉闭塞(LCx组);3)左前降支(LAD)闭塞(LAD组)。通过心脏磁共振扫描对左房、左室重塑和缺血性二尖瓣返流进行评

目前,对心梗后的左房重塑的认识尚浅。本研究的目的旨在利用心肌梗塞的猪模型来评估左房结构重塑的能力,并阐明左房重塑是如何影响二尖瓣返流的进展。本研究共建立了3个动物模型:1) 近端左回旋支(LCX)包括左房分支冠状动脉闭塞(左房梗塞组);2)近端左回旋支(LCX)不包括左房分支冠状动脉闭塞(LCx组);3)左前降支(LAD)闭塞(LAD组)。通过心脏磁共振扫描对左房、左室重塑和缺血性二尖瓣返流进行评估。研究结果显示,在建模后1周和8周,相比于LCx组和LAD组,左房梗塞组猪的左房扩张更明显,左房功能的损害也更早更严重。缺血性二尖瓣返流在左房梗塞组中更为显着,组织切片结果确证了左房梗塞组心房的广泛梗死和纤维化,而LAD组的猪没有通过心脏磁共振和组织切片观察到左房重塑。本研究首次为急性左房梗塞对心房重塑造成的影响提供了实验证据,急性左房梗塞会引起早期的左房扩张、功能不全、纤维化和二尖瓣返流。原始出处:Jaume A et al.Atrial Infarction and Ischemic Mitral Regurgitation Contribute to Post-MI Remodelin

版权声明:
本网站所有内容来源注明为“williamhill asia 医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于williamhill asia 医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“williamhill asia 医学”。其它来源的文章系转载文章,或“williamhill asia 号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与williamhill asia 联系,williamhill asia 将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1853871, encodeId=75b218538e1c6, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Nov 18 20:57:00 CST 2018, time=2018-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325631, encodeId=e0d1132563137, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Tue Dec 12 05:57:00 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626860, encodeId=09631626860d7, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Tue Dec 12 05:57:00 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268603, encodeId=1c03268603a7, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Dec 11 13:22:07 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268468, encodeId=8c04268468cc, content=一起学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Mon Dec 11 00:35:30 CST 2017, time=2017-12-11, status=1, ipAttribution=)]
    2018-11-18 hbwxf
  2. [GetPortalCommentsPageByObjectIdResponse(id=1853871, encodeId=75b218538e1c6, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Nov 18 20:57:00 CST 2018, time=2018-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325631, encodeId=e0d1132563137, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Tue Dec 12 05:57:00 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626860, encodeId=09631626860d7, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Tue Dec 12 05:57:00 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268603, encodeId=1c03268603a7, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Dec 11 13:22:07 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268468, encodeId=8c04268468cc, content=一起学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Mon Dec 11 00:35:30 CST 2017, time=2017-12-11, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1853871, encodeId=75b218538e1c6, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Nov 18 20:57:00 CST 2018, time=2018-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325631, encodeId=e0d1132563137, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Tue Dec 12 05:57:00 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626860, encodeId=09631626860d7, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Tue Dec 12 05:57:00 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268603, encodeId=1c03268603a7, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Dec 11 13:22:07 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268468, encodeId=8c04268468cc, content=一起学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Mon Dec 11 00:35:30 CST 2017, time=2017-12-11, status=1, ipAttribution=)]
    2017-12-12 sodoo
  4. [GetPortalCommentsPageByObjectIdResponse(id=1853871, encodeId=75b218538e1c6, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Nov 18 20:57:00 CST 2018, time=2018-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325631, encodeId=e0d1132563137, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Tue Dec 12 05:57:00 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626860, encodeId=09631626860d7, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Tue Dec 12 05:57:00 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268603, encodeId=1c03268603a7, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Dec 11 13:22:07 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268468, encodeId=8c04268468cc, content=一起学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Mon Dec 11 00:35:30 CST 2017, time=2017-12-11, status=1, ipAttribution=)]
    2017-12-11 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1853871, encodeId=75b218538e1c6, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Nov 18 20:57:00 CST 2018, time=2018-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325631, encodeId=e0d1132563137, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Tue Dec 12 05:57:00 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626860, encodeId=09631626860d7, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Tue Dec 12 05:57:00 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268603, encodeId=1c03268603a7, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Dec 11 13:22:07 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268468, encodeId=8c04268468cc, content=一起学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Mon Dec 11 00:35:30 CST 2017, time=2017-12-11, status=1, ipAttribution=)]
    2017-12-11 wzb521zf

    一起学习一下

    0

相关威廉亚洲官网

心血管症状发于病毒感染后 诊治兼顾最终揪出“凶手”

27岁男性患者因“间断心悸、黑矇2月,突发晕厥1次”于2011年3月25日入院。经问诊,得知患者发生心血管症状前曾患上呼吸感染,发病时主要表现为心脑血管供血不足的症状,再结合心电图“三度AVB”,确诊为病毒性心肌炎。本例中需注意收集病史对诊断疾病的重要性以及诊断和治疗如何同时兼顾。近似试验性的治疗可以改善患者症状,并为进一步明确诊断提供依据。

与情绪波动相关的心血管疾病

影视作品及小说中williamhill asia 常常能看到角色因受到各种事件的刺激导致激动或焦虑情绪,从而出现胸闷、心悸、呼吸困难乃至晕厥的情况。那么从医学上考虑引发这种症状的疾病可能是心梗、缺血性心肌病等,但这些都是有既往病史的,那么没有既往疾病的情况会是什么呢?让williamhill asia 看看下面的病例吧。病史:患者为一53岁中年女性,平素体健,平常爱好打牌,既往否认高血压及糖尿病病史,否认其他特殊病史及药物过敏史。1个小时前,患者如平时一样

JACC:卵圆孔封堵术可以缓解偏头痛?

偏头痛是一种较普遍且棘手的疾病,既往研究显示卵圆孔未闭(PFO)与偏头痛存在关联性,但其在偏头痛中的具体机制尚未阐明。本研究的目的旨在评估经皮PFO封堵术在有或无先兆的偏头痛中的疗效性。PREMIUM临床研究是随机双盲试验,将偏头痛患者随机分成药物治疗加假手术组和药物联合经皮卵圆孔封堵术治疗组,并随访观察1年患者的临床特征。主要终点事件是偏头痛和相关不良反应发生率至少减少50%,次要终点事件是患者

JACC:欧洲感染性心内膜炎流行病学变化趋势的研究

目前,欧洲尚缺乏基于大样本研究的感染性心内膜炎(IE)流行病学的变化趋势。 本回顾性、基于人群的时间趋势研究纳入了2003年至2014年西班牙国家卫生系统记录的诊断为感染性心内膜炎的出院患者,对其发病率、流行病学资料和预后进行了全面详细的评估和分析。最终,共纳入16867名IE患者,男性占66.3%。IE的发病率从2003年的2.72/10万人年增至2014年的3.49/10万人年,这种增加

JACC:ABSORB Ⅲ期临床试验3年随访结果出炉——生物可吸收支架远期预后不容乐观

可吸收依维莫司洗脱的聚左旋乳酸生物可吸收支架(BVS)可以提供类似于金属药物洗脱支架(DES)的药物作用和机械支撑。ABSORB第3期临床试验将2008名冠心病患者随机分成BVS组和钴铬合金依维莫司洗脱支架(EES)组,随访1年的结果显示了BVS在靶器官损伤(心源性死亡、靶血管心肌梗死和缺血性靶病变血运重建)的非劣效性。本研究的目的旨在评估BVS植入后3年的患者预后结局。随访3年后,复合主要终点事

JACC:低钠联合DASH饮食能显著改善高血压

减少钠的摄入和DASH(Dietary Approaches to Stop Hypertension)饮食(一种富含水果、蔬菜和低脂产品,而饱和脂肪酸和胆固醇较少的食谱)均有降低血压的功能。然而,这些干预方式对基线血压水平的单独和联合效果尚未阐明。本研究的目的旨在比较评估低钠摄入和高钠摄入、DASH饮食和对照、低钠联合DASH饮食和高钠对照饮食对基线收缩压水平的影响。本研究纳入了高血压前期或1期