Radiology:减肥可减缓关节退行性改变

2017-05-02 tulip1999 来宝网

肥胖是骨关节炎已知的危险因素,是造成美国居民残疾的主要原因之一。一项最新研究提供的证据表明,减肥可以减缓膝关节骨性关节炎的进展,减少膝关节软骨的退化。

肥胖是骨关节炎已知的危险因素,是造成美国居民残疾的主要原因之一。一项最新研究提供的证据表明,减肥可以减缓膝关节骨性关节炎的进展,减少膝关节软骨的退化。

研究人员发现,与没有进行减肥的人群相比,超重或肥胖成年人将体重减轻5%或10%持续四年以上,其膝关节结构的退行性改变明显有所减缓。

该项研究的主要作者,加利福尼亚大学旧金山分校放射科学与生物医学成像系的Alexandra Gersing博士及其同事在《放射学》杂志上报道了他们的最新发现。

骨关节炎(OA),又称退行性关节病,是美国居民最常见的一种关节炎,大约有3,000万多名美国成年人受累。

这种疾病是由于软骨破坏所引起的。

超重或肥胖是骨关节炎(OA)的主要危险因素;多余的体重会给关节和软骨带来额外的压力,造成“磨损”。

此外,Gersing博士及其同事指出,体脂肪过高会增加血液中促炎性物质,增加骨关节炎(OA)风险。

在他们的研究中,研究人员试图去更好地了解体重减轻对关节健康会有什么影响。

“williamhill asia 仔细查看了所有膝关节结构的退化情况,如半月板、关节软骨以及骨髓等,”Gersing博士指出。

研究人员对640名超重或肥胖的成年人进行了分析。所有参与者均存在骨关节炎(OA)危险因素或经MRI扫描确定患有轻至中度骨关节炎(OA)。

在为期48个月的研究过程中,研究人员监测受试者体重的变化及其膝关节退行性变的情况。

根据他们在这4年期间的体重变化,将参与者分为三组:减重超过10%的成年人,减重在5%-10%的成年人以及体重没有什么变化的成年人(对照组)。

与对照组相比,研究人员发现,减重至少5%的成年人其膝关节软骨变性有所减缓,减缓的程度甚至超过了那些减重超过10%以上的参与者。

“williamhill asia 的研究中最令人兴奋的发现是,williamhill asia 不仅能够看到关节软骨退行性变有所减缓,还看到了那些超重和肥胖人群在减重超过5%以上时其半月板退行性变明显减缓,而且减缓的效果明显大于超重者和减重最多者,”Gersing博士说道。

总的来说,研究人员相信,他们的研究结果表明减轻体重如何能够降低超重或肥胖患者的骨关节炎(OA)风险。

“williamhill asia 的研究强调了个体化治疗策略和生活方式干预的重要性,以便尽早预防肥胖和超重患者发生膝关节退行性变的风险。”Alexandra Gersing博士如是说。

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    2017-05-08 困困困

    学习

    0

  3. 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    2017-05-05 明天会更好!

    学习了,涨知识了

    0

  4. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170110/IMG587462ED91F877489.jpg, createdBy=cf801984270, createdName=多福爱, createdTime=Wed May 03 12:32:32 CST 2017, time=2017-05-03, status=1, ipAttribution=)]
    2017-05-05 1e10eabem79(暂无匿称)

    似乎早己有相关研究发表,创新之处在哪里?

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed May 03 13:48:13 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193263, encodeId=030219326316, content=减肥可以改善好多疾病好像, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed May 03 12:53:02 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193258, encodeId=a59f19325849, content=看起来减重5-10%关节获益更大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170110/IMG587462ED91F877489.jpg, createdBy=cf801984270, createdName=多福爱, createdTime=Wed May 03 12:32:32 CST 2017, time=2017-05-03, status=1, ipAttribution=)]
    2017-05-04 lovetcm

    可以减少关节退变,又一好处

    0

  6. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170110/IMG587462ED91F877489.jpg, createdBy=cf801984270, createdName=多福爱, createdTime=Wed May 03 12:32:32 CST 2017, time=2017-05-03, status=1, ipAttribution=)]
    2017-05-04 hanchunhee

    又一个控制体重的好处。学习了。

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed May 03 13:48:13 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193263, encodeId=030219326316, content=减肥可以改善好多疾病好像, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed May 03 12:53:02 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193258, encodeId=a59f19325849, content=看起来减重5-10%关节获益更大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170110/IMG587462ED91F877489.jpg, createdBy=cf801984270, createdName=多福爱, createdTime=Wed May 03 12:32:32 CST 2017, time=2017-05-03, status=1, ipAttribution=)]
    2017-05-04 flyingzyx

    谢谢分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1814210, encodeId=2f7818142109b, content=<a href='/topic/show?id=65ea946856c' target=_blank style='color:#2F92EE;'>#退行性改变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94685, encryptionId=65ea946856c, topicName=退行性改变)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Mon Jul 24 02:16:00 CST 2017, time=2017-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195386, encodeId=7f0f1953868f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/08/c21d3b1a18c65a8b0083f702f5145c33.jpg, createdBy=53312013589, createdName=困困困, createdTime=Mon May 08 11:53:28 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194121, encodeId=ec9d1941215a, content=学习了,涨知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Fri May 05 11:30:21 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193876, encodeId=41791938e6a1, content=似乎早己有相关研究发表,创新之处在哪里?, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5gJeAA33pg8XSpMyoXQLg4TTWfCC26g4ibkFFUdQVBtofBwAITTWib8S4f1bKDLaYsKVz2KtVfhLQJoia5mISjlibk/0, createdBy=28331949612, createdName=1e10eabem79(暂无匿称), createdTime=Fri May 05 00:21:55 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193593, encodeId=fec8193593de, content=可以减少关节退变,又一好处, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Thu May 04 07:49:44 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193519, encodeId=e99e1935196b, content=又一个控制体重的好处。学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAU2wVkTeANBK9R3rSMa9LcU72r7swR61YTJ7oZWL1MzhnJhRqMIsPZvCgHPwqmpYhDYKYK7dcwibS/0, createdBy=0cab1623974, createdName=hanchunhee, createdTime=Thu May 04 06:42:33 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193479, encodeId=f6fc1934e973, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2SEXGDldsNfP4rKvY7vJmaHcyvLXicuyaCTJtVOkX3jvd6DwNMD88hDjJwsU7MnUH6zeqC4zt3yGV/0, createdBy=4e701628585, createdName=flyingzyx, createdTime=Thu May 04 05:27:45 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193278, encodeId=e2d81932e81e, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed May 03 13:48:13 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193263, encodeId=030219326316, content=减肥可以改善好多疾病好像, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed May 03 12:53:02 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193258, encodeId=a59f19325849, content=看起来减重5-10%关节获益更大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170110/IMG587462ED91F877489.jpg, createdBy=cf801984270, createdName=多福爱, createdTime=Wed May 03 12:32:32 CST 2017, time=2017-05-03, status=1, ipAttribution=)]
    2017-05-03 天涯183

    非常好的文章,学习了,很受益

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1814210, encodeId=2f7818142109b, content=<a href='/topic/show?id=65ea946856c' target=_blank style='color:#2F92EE;'>#退行性改变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94685, encryptionId=65ea946856c, topicName=退行性改变)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Mon Jul 24 02:16:00 CST 2017, time=2017-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195386, encodeId=7f0f1953868f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/08/c21d3b1a18c65a8b0083f702f5145c33.jpg, createdBy=53312013589, createdName=困困困, createdTime=Mon May 08 11:53:28 CST 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createdName=1e10eabem79(暂无匿称), createdTime=Fri May 05 00:21:55 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193593, encodeId=fec8193593de, content=可以减少关节退变,又一好处, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Thu May 04 07:49:44 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193519, encodeId=e99e1935196b, content=又一个控制体重的好处。学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAU2wVkTeANBK9R3rSMa9LcU72r7swR61YTJ7oZWL1MzhnJhRqMIsPZvCgHPwqmpYhDYKYK7dcwibS/0, createdBy=0cab1623974, createdName=hanchunhee, createdTime=Thu May 04 06:42:33 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193479, encodeId=f6fc1934e973, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2SEXGDldsNfP4rKvY7vJmaHcyvLXicuyaCTJtVOkX3jvd6DwNMD88hDjJwsU7MnUH6zeqC4zt3yGV/0, createdBy=4e701628585, createdName=flyingzyx, createdTime=Thu May 04 05:27:45 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193278, encodeId=e2d81932e81e, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed May 03 13:48:13 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193263, encodeId=030219326316, content=减肥可以改善好多疾病好像, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed May 03 12:53:02 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193258, encodeId=a59f19325849, content=看起来减重5-10%关节获益更大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170110/IMG587462ED91F877489.jpg, createdBy=cf801984270, createdName=多福爱, createdTime=Wed May 03 12:32:32 CST 2017, time=2017-05-03, status=1, ipAttribution=)]
    2017-05-03 1ddf0692m34(暂无匿称)

    减肥可以改善好多疾病好像

    0

  10. 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createdName=hanchunhee, createdTime=Thu May 04 06:42:33 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193479, encodeId=f6fc1934e973, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2SEXGDldsNfP4rKvY7vJmaHcyvLXicuyaCTJtVOkX3jvd6DwNMD88hDjJwsU7MnUH6zeqC4zt3yGV/0, createdBy=4e701628585, createdName=flyingzyx, createdTime=Thu May 04 05:27:45 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193278, encodeId=e2d81932e81e, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed May 03 13:48:13 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193263, encodeId=030219326316, content=减肥可以改善好多疾病好像, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed May 03 12:53:02 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193258, encodeId=a59f19325849, content=看起来减重5-10%关节获益更大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170110/IMG587462ED91F877489.jpg, createdBy=cf801984270, createdName=多福爱, createdTime=Wed May 03 12:32:32 CST 2017, time=2017-05-03, status=1, ipAttribution=)]
    2017-05-03 多福爱

    看起来减重5-10%关节获益更大。

    0

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Arthritis Res Ther:葡萄糖胺联合双醋瑞因治疗并不能改善骨关节炎患者的症状

据发表于 Arthritis Res Ther的一项新的研究显示,与葡萄糖胺单药治疗相比,葡萄糖胺联合双醋瑞因治疗并不能改善疼痛评分。葡萄糖胺具有合成代谢的作用,而双醋瑞因具有分解代谢的作用,因此研究人员推测联合两种药物治疗或较单药治疗能更好的改善患者的疼痛和功能。为了验证这一假设,研究人员进行了一项双盲,平行,随机对照试验,研究共纳入了148名(平均年龄为60岁)轻度到中度的膝骨关节炎

同样是THA治疗,髋部骨折患者的术后发病率高于OA患者

接受全髋关节置换术(THA)治疗髋部骨折的患者,与接受全髋关节置换术治疗骨性关节炎(OA)的患者比较,术后并发症的风险增加。 全髋关节置换术是治疗髋关节退行性疾病的一种常规的外科手术方式。 David W. Fitz博士和他的同事们回顾了2011和2014年之间的国家外科质量改进计划数据,确定58302例接受THA治疗的OA患者,以及1580例接受THA治疗髋部骨折的患者。 研究

专家述评--重新认识膝骨性关节炎的诊断和防治

随着老龄化社会的到来,我国老年人绝对数呈增高趋势,骨性关节炎患者人数亦增多,尤其是膝关节等大关节的发病率、致残率亦呈增高趋势,这引起了科研工作者、医生的高度关注。国内外诊治膝骨性关节炎大多采用美国风湿病学会(ACR)1995年颁布的膝骨性关节炎的诊疗威廉亚洲博彩公司 。我国于2002年由中华医学会风湿病学分会制定了《骨关节炎诊治威廉亚洲博彩公司 (草案)》,并由中华医学会骨科分会制定了《骨关节炎诊治威廉亚洲博彩公司 (2007版)》。

胫骨高位截骨术治疗膝关节骨关节炎的现状

Coventry首先报道并倡导的胫骨高位截骨术(HTO)经过了超过50年的临床应用,如今已经发展成为一项更安全,准确而又有效的手术技术,每年治疗数以万计的膝关节骨关节炎患者。HTO的初衷是通过胫骨近端截骨,把力线从发生炎症和磨损的膝关节内侧间室,转移到相对正常的外侧间室,从而达到缓解关节炎症状并延长膝关节的寿命的目的。对于正常力线的膝关节来说,就是内侧负重多(60%),而外侧负重少。如果胫骨还

膝关节骨关节炎影像学诊断与步态评估进展

膝关节骨关节炎(KOA)是一种以膝关节软骨变形和丢失、关节缘和软骨下骨骨质再生为特征的慢性关节炎疾病,是中老年人群中最常见的慢性关节退行性疾病;40岁以上人群中男性患病率达23.5%,女性患病率达32.8%,女性发病率高于男性,而且总发病率逐年增加。KOA可以引起膝关节疼痛,使关节活动受限和功能部分丧失。随着老龄化时代的到来,而且患者对于生活质量的要求越来越高,对该疾病及早发现并治疗显得越发重

FASEB J:高胆固醇血症与骨关节炎的发生发展相关

高胆固醇不仅会损害机体的心血管系统。近期发表于FASEB的一项新的研究利用动物模型发现,高胆固醇可引发线粒体对软骨细胞的氧化应激,导致细胞死亡,并最终导致骨关节炎的发生发展。本研究测试了线粒体靶向抗氧化剂在高胆固醇诱导的骨关节炎中潜在的治疗作用,并位使用线粒体靶向抗氧化剂治疗骨关节炎提供证据支持。研究人员使用两种不同的动物模型来模拟人类高胆固醇血症。第一种动物模型是携带改变基因的小鼠,这个基因称为