Front Neurosci:在年龄相关的听力损失中,维他命A、C、E和Mg++组合口服能够改善听觉阈值

2018-08-21 AlexYang MedSci原创

目前,年龄相关的听力损失(ARHL)增长速度加快,且伴随随后生活质量的下降和健康治疗的花费的增加,因此,需要新的治疗策略来减少和延迟该疾病造成的影响。最近,有研究人员调查了是否ARHL可以通过抗氧化物维他命A、C和E的自由基清除作用,加以Mg++组合使用(一个已知的有效的耳蜗血管舒张药(ACEMg)),能够减少ARHL产生的影响。研究包括了2个小组,ND组(正常饮食组)和ED组(包含上述药物组),

目前,年龄相关的听力损失(ARHL)增长速度加快,且伴随随后生活质量的下降和健康治疗的花费的增加,因此,需要新的治疗策略来减少和延迟该疾病造成的影响。最近,有研究人员调查了是否ARHL可以通过抗氧化物维他命A、C和E的自由基清除作用,加以Mg++组合使用(一个已知的有效的耳蜗血管舒张药(ACEMg)),能够减少ARHL产生的影响。

研究包括了2个小组,ND组(正常饮食组)和ED组(包含上述药物组),研究对象为3个月的大Wistar大鼠。研究人员在噪音刺激的前10天进行ED模式饲养,并在3, 6-8和12-14个月大时在 0.5, 1, 2, 4, 8, 16和32 kHz进行听觉脑干记录(ABR)。研究发现,在3个月大时,ND组和ED组没有观察到显著的差异。在6-8个月和12-14个月时,听觉阈值具有显著的增加,且在所有测试的频率中波振幅具有明显的减少,上述情况与ARHL的恶性发展一致。然而,在6-8个月大时,与ND组相比,ED组的阈值偏移在低和中等频率时显著更低,并且波振幅在所有的品率中显著更大。 在年龄最大组中,阈值偏移差异和波振幅仍旧存在,表明了ACEMg对听觉功能具有持续的保护作用。

最后,研究人员指出,他们的发现表明了口服ACEMg可作为治疗ARHL的一种有效的辅助治疗手段,从而推迟年龄相关听力损伤恶化引起的不良影响。

原始出处:

Alvarado JC, Fuentes-Santamaría V, Gabaldón-Ull MC et al. An Oral Combination of Vitamins A, C, E, and Mg++ Improves Auditory Thresholds in Age-Related Hearing Loss. Front Neurosci. 31 July 2018.

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    2018-08-23 ysjykql
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    2018-08-23 lsndxfj
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    2018-08-23 qjddjq
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    2018-08-22 AlexYang

    韩文刚,学习了!

    0

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    2018-08-21 phoebeyan520

    学习了

    0

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    2018-08-21 哈哈869

    学习了

    0

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    2018-08-21 ylzr123

    好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。

    0

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    2018-08-21 小小小麦兜

    学习了

    0

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